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Molecular Biology

D-Index
57
Citations
16084
World Ranking
2133
National Ranking
1060

Overview

Jun Ninomiya-Tsuji is affiliated with North Carolina State University in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine. Within these disciplines, their work aligns closely with subfields including genetics, immunology, hematology, health, toxicology and mutagenesis, and inorganic chemistry.

The scientist's research topics cover a range of biological and chemical subjects. These include Yersinia bacterium, plague, and ectoparasite research; immune response and inflammation; iron metabolism and related disorders; chromium effects and bioremediation; radioactive element chemistry and processing; Helicobacter pylori-associated gastroenterology studies; and NF-κB signaling pathways.

Several recent papers illustrate the scope of Jun Ninomiya-Tsuji's contributions. These include:

  • "TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization," 2021, Proceedings of the National Academy of Sciences
  • "Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer's disease mouse models," 2023, Journal of Cell Science
  • "Modulation of iron metabolism by new chemicals interacting with the iron regulatory system," 2024, Redox Biology
  • "TAK1 Inhibition Elicits Mitochondrial ROS to Block Intracellular Bacterial Colonization," 2021, The FASEB Journal
  • "Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis," 2021, UNC Libraries

Frequent collaborators in their research include Wilfred López-Pérez, Kazuhito Sai, Yosuke Sakamachi, Cameron Parsons, and Sophia Kathariou. The partnerships with these coauthors have contributed multiple publications.

Common venues for Jun Ninomiya-Tsuji's publications include UNC Libraries, Journal of Biological Chemistry, SSRN Electronic Journal, Proceedings of the National Academy of Sciences, and Journal of Cell Science. UNC Libraries and Journal of Biological Chemistry are among the most frequent outlets.

Best Publications

  • The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

    Jun Ninomiya-Tsuji;Kazuya Kishimoto;Atsushi Hiyama;Jun-ichiro Inoue

  • Essential function for the kinase TAK1 in innate and adaptive immune responses.

    Shintaro Sato;Hideki Sanjo;Kiyoshi Takeda;Jun Ninomiya-Tsuji

  • The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

    Tohru Ishitani;Jun Ninomiya-Tsuji;Shln Ichl Nagai;Michiru Nishita

  • TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

    Giichi Takaesu;Satoshi Kishida;Atsushi Hiyama;Kyoko Yamaguchi

  • The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/β-Catenin Signaling

    Tohru Ishitani;Satoshi Kishida;Junko Hyodo-Miura;Junko Hyodo-Miura;Naoto Ueno

  • Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression.

    Hiroshi Hanafusa;Jun Ninomiya-Tsuji;Norihisa Masuyama;Michiru Nishita

  • TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway

    Giichi Takaesu;Rama M. Surabhi;Kyu-Jin Park;Jun Ninomiya-Tsuji

  • XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1–TAK1 in the BMP signaling pathway

    Kyoko Yamaguchi;Shin-ichi Nagai;Jun Ninomiya-Tsuji;Michiru Nishita

  • A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase

    Jun Ninomiya-Tsuji;Taisuke Kajino;Koichiro Ono;Toshihiko Ohtomo

  • Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol

    Zhengfan Jiang;Jun Ninomiya-Tsuji;Youcun Qian;Kunihiro Matsumoto

  • MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans

    Marc D. Meneghini;Tohru Ishitani;J. Clayton Carter;Naoki Hisamoto

  • Role of the TAB2‐related protein TAB3 in IL‐1 and TNF signaling

    Tohru Ishitani;Giichi Takaesu;Jun Ninomiya-Tsuji;Hiroshi Shibuya

  • Receptor Activator of NF-κB Ligand (RANKL) Activates TAK1 Mitogen-Activated Protein Kinase Kinase Kinase through a Signaling Complex Containing RANK, TAB2, and TRAF6

    Junko Mizukami;Giichi Takaesu;Hiroyuki Akatsuka;Hiroaki Sakurai

  • TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.

    Kazuya Kishimoto;Kunihiro Matsumoto;Jun Ninomiya-Tsuji

  • AMP-Activated Protein Kinase Activates p38 Mitogen-Activated Protein Kinase by Increasing Recruitment of p38 MAPK to TAB1 in the Ischemic Heart

    Ji Li;Edward J. Miller;Jun Ninomiya-Tsuji;Raymond R. Russell

  • IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

    Hiroshi Shibuya;Mitsutoshi Yoneyama;Jun Ninomiya-Tsuji;Kunihiro Matsumoto

  • Regulation of Lymphoid Enhancer Factor 1/T-Cell Factor by Mitogen-Activated Protein Kinase-Related Nemo-Like Kinase-Dependent Phosphorylation in Wnt/β-Catenin Signaling

    Tohru Ishitani;Jun Ninomiya-Tsuji;Kunihiro Matsumoto

  • IRAK-mediated Translocation of TRAF6 and TAB2 in the Interleukin-1-induced Activation of NFκB

    Youcun Qian;Mairead Commane;Jun Ninomiya-Tsuji;Kunihiro Matsumoto

  • TAK1 control of cell death

    S R Mihaly;J Ninomiya-Tsuji;S Morioka;S Morioka

  • Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.

    Giichi Takaesu;Jun Ninomiya-Tsuji;Satoshi Kishida;Xiaoxia Li

Frequent Co-Authors

Kunihiro Matsumoto
Kunihiro Matsumoto Nagoya University
Shizuo Akira
Shizuo Akira Osaka University
Yuji Mishina
Yuji Mishina University of Michigan–Ann Arbor
Kenji Irie
Kenji Irie University of Tsukuba
Shintaro Sato
Shintaro Sato Osaka University
Christian Jobin
Christian Jobin University of Florida
Eugenia Morselli
Eugenia Morselli San Sebastián University
Hiroshi Shibuya
Hiroshi Shibuya Tokyo Medical and Dental University
David L. Brautigan
David L. Brautigan University of Virginia
Alfredo Criollo
Alfredo Criollo University of Chile

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