Kohsuke Takeda

Overview

Best Publications

• Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

  Masao Saitoh;Hideki Nishitoh;Makiko Fujii;Kohsuke Takeda

  2902
  Citations

• ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

  Hideki Nishitoh;Atsushi Matsuzawa;Kei Tobiume;Kaoru Saegusa

  1623
  Citations

• ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

  Kei Tobiume;Atsushi Matsuzawa;Takumi Takahashi;Hideki Nishitoh

  1440
  Citations

• ASK1 Is Essential for JNK/SAPK Activation by TRAF2

  Hideki Nishitoh;Masao Saitoh;Masao Saitoh;Yoshiyuki Mochida;Yoshiyuki Mochida;Kohsuke Takeda;Kohsuke Takeda

  831
  Citations

• ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

  Atsushi Matsuzawa;Kaoru Saegusa;Takuya Noguchi;Chiharu Sadamitsu

  775
  Citations

• ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

  Hideki Nishitoh;Hisae Kadowaki;Atsushi Nagai;Takeshi Maruyama

  621
  Citations

• Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation

  M Fujii;K Takeda;T Imamura;H Aoki

  599
  Citations

• Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation

  H. Kadowaki;H. Kadowaki;H. Nishitoh;H. Nishitoh;Fumihiko Urano;C. Sadamitsu

  526
  Citations

• HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

  Romas Geleziunas;Weiduan Xu;Kohsuke Takeda;Hidenori Ichijo

  478
  Citations

• The ASK1-MAP Kinase Cascades in Mammalian Stress Response

  Jun Matsukawa;Atsushi Matsuzawa;Kohsuke Takeda;Hidenori Ichijo

  425
  Citations

• Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

  Takiko Hatai;Atsushi Matsuzawa;Seiji Inoshita;Yoshiyuki Mochida

  423
  Citations

• GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.

  Genta Ito;Takuro Okai;Go Fujino;Kohsuke Takeda

  321
  Citations

• Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.

  Go Fujino;Takuya Noguchi;Atsushi Matsuzawa;Shota Yamauchi

  321
  Citations

• Pathophysiological roles of ASK1-MAP kinase signaling pathways.

  Hiroaki Nagai;Takuya Noguchi;Kohsuke Takeda;Hidenori Ichijo

  319
  Citations

• Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

  Atsushi Matsuzawa;Hideki Nishitoh;Kei Tobiume;Kohsuke Takeda

  314
  Citations

• Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress.

  Seiji Inoshita;Kohsuke Takeda;Takiko Hatai;Yoshio Terada

  294
  Citations

• Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death.

  Takuya Noguchi;Kohsuke Takeda;Atsushi Matsuzawa;Kaoru Saegusa

  289
  Citations

• Roles of MAPKKK ASK1 in stress-induced cell death.

  Kohsuke Takeda;Kohsuke Takeda;Atsushi Matsuzawa;Hideki Nishitoh;Hideki Nishitoh;Hidenori Ichijo;Hidenori Ichijo

  286
  Citations

• Apoptosis signal-regulating kinase 1 in stress and immune response.

  Kohsuke Takeda;Takuya Noguchi;Isao Naguro;Hidenori Ichijo

  271
  Citations

• Induction of Smad6 mRNA by Bone Morphogenetic Proteins

  Takase M;Imamura T;Sampath Tk;Takeda K

  241
  Citations