The scientist’s investigation covers issues in ASK1, Cell biology, MAP kinase kinase kinase, Signal transduction and Apoptosis. His ASK1 research focuses on Cancer research and how it connects with Protein kinase R. The study of Cell biology is intertwined with the study of Programmed cell death in a number of ways.
His MAP kinase kinase kinase research is multidisciplinary, incorporating perspectives in Cyclin-dependent kinase 9, Mitogen-activated protein kinase kinase and MAP2K7. His work investigates the relationship between Signal transduction and topics such as Molecular biology that intersect with problems in Alkaline phosphatase, SMAD, Bone morphogenetic protein and Receptor. Kohsuke Takeda has researched Apoptosis in several fields, including Oxidative stress and Bystander effect.
Cell biology, ASK1, Kinase, Molecular biology and MAP kinase kinase kinase are his primary areas of study. His ASK1 research integrates issues from Mitogen-activated protein kinase and Cancer research. The Molecular biology study combines topics in areas such as Bone morphogenetic protein 10 and Complementary DNA, cDNA library, Gene, Bone morphogenetic protein.
His MAP kinase kinase kinase research includes themes of Cyclin-dependent kinase 9, Mitogen-activated protein kinase kinase and MAP2K7. His research in MAP2K7 intersects with topics in MAPK14 and Protein kinase R. His Signal transduction research is multidisciplinary, incorporating elements of Unfolded protein response, Endoplasmic reticulum and Thioredoxin.
His primary areas of study are Cell biology, ASK1, Mitochondrion, Inflammasome and Kinase. His ASK1 research incorporates themes from Signal transduction, Metastasis and Cytokine. His Mitochondrion study incorporates themes from Secretion, Mitophagy and Phosphatase.
His Inflammasome study combines topics from a wide range of disciplines, such as Proinflammatory cytokine and Programmed cell death. His study of MAP kinase kinase kinase is a part of Protein kinase A. His MAP kinase kinase kinase research includes elements of Molecular biology and Osmotic shock.
Kohsuke Takeda mainly investigates Cell biology, Kinase, ASK1, Phosphorylation and Protein kinase A. The Cell biology study combines topics in areas such as Inflammasome and Caspase 1. Kohsuke Takeda regularly links together related areas like Metastasis in his Kinase studies.
His Phosphorylation research incorporates elements of Platelet and Cancer research. His study in Protein kinase A focuses on MAP kinase kinase kinase in particular. His work deals with themes such as Molecular biology, RNA interference and Osmotic shock, which intersect with MAP kinase kinase kinase.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
Masao Saitoh;Hideki Nishitoh;Makiko Fujii;Kohsuke Takeda.
The EMBO Journal (1998)
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
Hideki Nishitoh;Atsushi Matsuzawa;Kei Tobiume;Kaoru Saegusa.
Genes & Development (2002)
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
Kei Tobiume;Atsushi Matsuzawa;Takumi Takahashi;Hideki Nishitoh.
EMBO Reports (2001)
ASK1 Is Essential for JNK/SAPK Activation by TRAF2
Hideki Nishitoh;Masao Saitoh;Masao Saitoh;Yoshiyuki Mochida;Yoshiyuki Mochida;Kohsuke Takeda;Kohsuke Takeda.
Molecular Cell (1998)
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
Atsushi Matsuzawa;Kaoru Saegusa;Takuya Noguchi;Chiharu Sadamitsu.
Nature Immunology (2005)
Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation
M Fujii;K Takeda;T Imamura;H Aoki.
Molecular Biology of the Cell (1999)
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
Hideki Nishitoh;Hisae Kadowaki;Atsushi Nagai;Takeshi Maruyama.
Genes & Development (2008)
HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
Romas Geleziunas;Weiduan Xu;Kohsuke Takeda;Hidenori Ichijo.
Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation
Takiko Hatai;Atsushi Matsuzawa;Seiji Inoshita;Yoshiyuki Mochida.
Journal of Biological Chemistry (2000)
Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation
H. Kadowaki;H. Kadowaki;H. Nishitoh;H. Nishitoh;Fumihiko Urano;C. Sadamitsu.
Cell Death & Differentiation (2005)
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