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Hideki Nishitoh

Hideki Nishitoh

D-Index & Metrics

Biology and Biochemistry

D-Index
44
Citations
16395
World Ranking
19192
National Ranking
1383

Overview

Hideki Nishitoh is a researcher affiliated with the University of Miyazaki in Japan, specializing in biochemistry and molecular biology with additional contributions to neuroscience. Their research addresses various aspects of cellular and molecular mechanisms, particularly focusing on endoplasmic reticulum stress, adipose tissue metabolism, mitochondrial function, and neurodegenerative diseases.

The main fields of study associated with Nishitoh include Biochemistry, Genetics and Molecular Biology, with a substantial number of publications spanning Neuroscience as well. Their work is further subdivided into relevant subfields such as Molecular Biology, Cell Biology, Physiology, Cellular and Molecular Neuroscience, and Developmental Neuroscience.

The scientist's research encompasses these main topics:

  • Endoplasmic Reticulum Stress and Disease
  • Adipose Tissue and Metabolism
  • Mitochondrial Function and Pathology
  • Ubiquitin and proteasome pathways
  • RNA regulation and disease
  • Neurogenesis and neuroplasticity mechanisms
  • Nuclear Receptors and Signaling

Among the frequent publication venues for Nishitoh's work are The Journal of Biochemistry, Nature Communications, Life Science Alliance, iScience, and Scientific Reports.

Nishitoh has collaborated repeatedly with several notable coauthors, including Hisae Kadowaki, Takashi Sugiyama, Naoya Murao, Kousuke Tanimoto, and Yosuke Matsushita.

Selected recent papers illustrate the thematic range of their research:

  • ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue (2020), published in Life Science Alliance
  • ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress (2025), published in Nature Communications
  • ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function (2021), published in iScience
  • Neurodegenerative diseases associated with the disruption of proteostasis and their therapeutic strategies using chemical chaperones (2024), published in The Journal of Biochemistry
  • Chemical chaperones ameliorate neurodegenerative disorders in Derlin-1-deficient mice via improvement of cholesterol biosynthesis (2022), published in Scientific Reports

Best Publications

  • Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

    Masao Saitoh;Hideki Nishitoh;Makiko Fujii;Kohsuke Takeda

  • ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

    Hideki Nishitoh;Atsushi Matsuzawa;Kei Tobiume;Kaoru Saegusa

  • ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

    Kei Tobiume;Atsushi Matsuzawa;Takumi Takahashi;Hideki Nishitoh

  • ASK1 Is Essential for JNK/SAPK Activation by TRAF2

    Hideki Nishitoh;Masao Saitoh;Masao Saitoh;Yoshiyuki Mochida;Yoshiyuki Mochida;Kohsuke Takeda;Kohsuke Takeda

  • ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

    Atsushi Matsuzawa;Kaoru Saegusa;Takuya Noguchi;Chiharu Sadamitsu

  • Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx

    Howard Y. Chang;Hideki Nishitoh;Xiaolu Yang;Hidenori Ichijo

  • Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

    Hong Liu;Hideki Nishitoh;Hidenori Ichijo;John M. Kyriakis

  • ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

    Hideki Nishitoh;Hisae Kadowaki;Atsushi Nagai;Takeshi Maruyama

  • Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation

    H. Kadowaki;H. Kadowaki;H. Nishitoh;H. Nishitoh;Fumihiko Urano;C. Sadamitsu

  • CHOP is a multifunctional transcription factor in the ER stress response.

    Hideki Nishitoh

  • Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5

    Hideki Nishitoh;Hidenori Ichijo;Michio Kimura;Tomoaki Matsumoto

  • Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.

    Kei‐ichi Morita;Masao Saitoh;Kei Tobiume;Hiroshi Matsuura

  • Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

    Atsushi Matsuzawa;Hideki Nishitoh;Kei Tobiume;Kohsuke Takeda

  • Roles of MAPKKK ASK1 in stress-induced cell death.

    Kohsuke Takeda;Kohsuke Takeda;Atsushi Matsuzawa;Hideki Nishitoh;Hideki Nishitoh;Hidenori Ichijo;Hidenori Ichijo

  • Tumor Growth Inhibition by Arsenic Trioxide (As2O3) in the Orthotopic Metastasis Model of Androgen-independent Prostate Cancer

    Hiroshi Maeda;Seiji Hori;Hideki Nishitoh;Hidenori Ichijo

  • The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

    Keiko Imamura;Yuishin Izumi;Akira Watanabe;Kayoko Tsukita

  • Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.

    Kohsuke Takeda;Atsushi Matsuzawa;Hideki Nishitoh;Kei Tobiume

  • Apoptosis Signal-regulating Kinase 1 (ASK1) Induces Neuronal Differentiation and Survival of PC12 Cells

    Kohsuke Takeda;Takiko Hatai;Tatsuo S. Hamazaki;Hideki Nishitoh

  • Signaling pathways from the endoplasmic reticulum and their roles in disease.

    Hisae Kadowaki;Hideki Nishitoh

  • Survival and apoptosis signals in ER stress: the role of protein kinases.

    Hisae Kadowaki;Hideki Nishitoh;Hideki Nishitoh;Hidenori Ichijo

Frequent Co-Authors

Hidenori Ichijo
Hidenori Ichijo University of Tokyo
Kohsuke Takeda
Kohsuke Takeda Nagasaki University
Atsushi Matsuzawa
Atsushi Matsuzawa Tohoku University
Kohei Miyazono
Kohei Miyazono University of Tokyo
Hitomi Mimuro
Hitomi Mimuro Osaka University
Kunihiro Matsumoto
Kunihiro Matsumoto Nagoya University
Akira Kakizuka
Akira Kakizuka Kyoto University
Juro Sakai
Juro Sakai University of Tokyo
Keizo Takao
Keizo Takao University of Toyama
Shoji Tsuji
Shoji Tsuji University of Tokyo

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