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Biology and Biochemistry

D-Index
64
Citations
13231
World Ranking
9774
National Ranking
655

Overview

Hiroshi Masutani is affiliated with Tenri Health Care University in Japan. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a particular emphasis on molecular biology and immunology. They have also contributed to studies in ecology, evolution, behavior and systematics, physiology, and agronomy and crop science.

The scientist's work covers multiple research topics, including:

  • Redox biology and oxidative stress
  • T-cell and retrovirus studies
  • Vector-borne animal diseases
  • Glutathione transferases and polymorphisms
  • Genomics, phytochemicals, and oxidative stress
  • Animal disease management and epidemiology
  • Ubiquitin and proteasome pathways

Masutani has published in several scientific venues, with frequent contributions to:

  • Antioxidants and Redox Signaling
  • Frontiers in Microbiology
  • FEBS Open Bio
  • Science Translational Medicine
  • Journal of Clinical Biochemistry and Nutrition

Their recent papers include:

  • Thioredoxin-Interacting Protein in Cancer and Diabetes, 2021, Antioxidants and Redox Signaling
  • IL-2/IL-2 Receptor Pathway Plays a Crucial Role in the Growth and Malignant Transformation of HTLV-1-Infected T Cells to Develop Adult T-Cell Leukemia, 2020, Frontiers in Microbiology
  • TXNIP induces growth arrest and enhances ABT263-induced apoptosis in mixed-lineage leukemia-rearranged acute myeloid leukemia cells, 2020, FEBS Open Bio
  • Redoxisome Update: TRX and TXNIP/TBP2-Dependent Regulation of NLRP-1/NLRP-3 Inflammasome, 2024, Antioxidants and Redox Signaling
  • β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome, 2025, Science Translational Medicine

Among frequent collaborators are Kikuko Amo-Shiinoki, Katsuya Tanabe, Syota Kagawa, Meng Zou, and Yukio Tanizawa, each having co-authored multiple publications with Masutani. This collaborative work spans several significant research topics related to oxidative stress, immune mechanisms, and molecular pathways involved in disease.

Best Publications

  • Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression

    Akira Nishiyama;Minoru Matsui;Satoshi Iwata;Kiichi Hirota

  • Redox Control of Cell Death

    Shugo Ueda;Hiroshi Masutani;Hajime Nakamura;Toru Tanaka

  • Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

    Masaya Ueno;Hiroshi Masutani;Roberto Jun Arai;Akira Yamauchi

  • Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation

    H. Kadowaki;H. Kadowaki;H. Nishitoh;H. Nishitoh;Fumihiko Urano;C. Sadamitsu

  • Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis.

    Toru Tanaka;Fumihito Hosoi;Yuko Yamaguchi-Iwai;Hajime Nakamura

  • Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors.

    Yong Chul Kim;Hiroshi Masutani;Yoshimi Yamaguchi;Ken Itoh

  • Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells.

    M Matsuda;H Masutani;H Nakamura;S Miyajima

  • Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity.

    Keisuke Shioji;Chiharu Kishimoto;Hajime Nakamura;Hiroshi Masutani

  • Enhanced Oxidative Stress and Impaired Thioredoxin Expression in Spontaneously Hypertensive Rats

    Masaki Tanito;Hajime Nakamura;Yong-Won Kwon;Akie Teratani

  • Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice

    Masaki Tanito;Hiroshi Masutani;Yong-Chul Kim;Mai Nishikawa

  • Redox Regulation of Caspase-3(-like) Protease Activity: Regulatory Roles of Thioredoxin and Cytochrome c

    Shugo Ueda;Hajime Nakamura;Hiroshi Masutani;Tetsuro Sasada

  • Thioredoxin as a Molecular Target of Cyclopentenone Prostaglandins

    Takahiro Shibata;Takaaki Yamada;Takeshi Ishii;Shigenori Kumazawa

  • Redox regulation by thioredoxin and thioredoxin-binding proteins.

    Akira Nishiyama;Hiroshi Masutani;Hajime Nakamura;Yumiko Nishinaka

  • Expression and growth-promoting effect of adult T-cell leukemia-derived factor. A human thioredoxin homologue in hepatocellular carcinoma.

    Hajime Nakamura;Hiroshi Masutani;Yutaka Tagaya;Akira Yamauchi

  • Loss of Thioredoxin-Binding Protein-2/Vitamin D3 Up-Regulated Protein 1 in Human T-Cell Leukemia Virus Type I-Dependent T-Cell Transformation Implications for Adult T-Cell Leukemia Leukemogenesis

    Yumiko Nishinaka;Akira Nishiyama;Hiroshi Masutani;Shin-ichi Oka

  • Redox regulation of human thioredoxin network.

    Norihiko Kondo;Hajime Nakamura;Hiroshi Masutani;Junji Yodoi

  • Redox regulation by thioredoxin superfamily; protection against oxidative stress and aging.

    Toru Tanaka;Hajime Nakamura;Akira Nishiyama;Fumihito Hosoi

  • Thioredoxin Superfamily and Thioredoxin‐Inducing Agents

    Kiichi Hirota;Hajime Nakamura;Hiroshi Masutani;Hiroshi Masutani;Junji Yodoi;Junji Yodoi

  • Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2

    Rie Watanabe;Hajime Nakamura;Hiroshi Masutani;Junji Yodoi

  • Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response.

    Yong-Chul Kim;Yoshimi Yamaguchi;Norihiko Kondo;Hiroshi Masutani;Hiroshi Masutani

Frequent Co-Authors

Junji Yodoi
Junji Yodoi Kyoto University
Hajime Nakamura
Hajime Nakamura Kyoto University
Akira Nishiyama
Akira Nishiyama Kagawa University
Kiichi Hirota
Kiichi Hirota Kansai Medical University
Shingo Fujii
Shingo Fujii Kyoto University
Michiyuki Maeda
Michiyuki Maeda Kyoto University
Akira Yamauchi
Akira Yamauchi Kawasaki Medical School
Annick Harel-Bellan
Annick Harel-Bellan Centre national de la recherche scientifique, CNRS
Ikuo Konishi
Ikuo Konishi Kyoto University
Yutaka Tagaya
Yutaka Tagaya University of Maryland, Baltimore

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