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Medicine

D-Index
92
Citations
30041
World Ranking
11343
National Ranking
5821

Overview

Garth Powis is affiliated with the Discovery Institute in the United States and focuses research in the fields of biochemistry, genetics, molecular biology, and medicine. Their work encompasses several subfields including molecular biology, cell biology, oncology, physiology, and immunology. The body of research is particularly concentrated on topics such as cellular transport and secretion, erythrocyte function and pathophysiology, protein kinase regulation and GTPase signaling, chemokine receptors and signaling, immunotherapy and immune responses, chronic lymphocytic leukemia research, and PI3K/AKT/mTOR signaling in cancer.

Recent publications by Powis include:

  • Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease, 2023, Biomedicine & Pharmacotherapy
  • Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids, 2021, Structure
  • Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models, 2020, UNC Libraries
  • PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer, 2021, Experimental Cell Research
  • A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A, 2020, SLAS DISCOVERY

Powis often collaborates with several frequent coauthors, including:

  • Alexander E. Aleshin
  • Yong Yao
  • Laurie A. Bankston
  • Robert Liddington
  • Francesca M. Marassi

Publications are distributed across a range of scientific venues such as Biomedicine & Pharmacotherapy, Structure, UNC Libraries, Experimental Cell Research, and SLAS DISCOVERY.

Best Publications

  • Properties and Biological Activities of Thioredoxins

    Garth Powis;William R Montfort

  • Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.

    Scott Kopetz;Jayesh Desai;Emily Chan;Joel Randolph Hecht

  • Free radical formation by antitumor quinones

    Garth Powis

  • Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

    Nathan T. Ihle;Lauren Averett Byers;Edward S. Kim;Pierre Saintigny

  • The Redox Protein Thioredoxin-1 (Trx-1) Increases Hypoxia-inducible Factor 1α Protein Expression: Trx-1 Overexpression Results in Increased Vascular Endothelial Growth Factor Production and Enhanced Tumor Angiogenesis

    Sarah J. Welsh;William T. Bellamy;Margaret M. Briehl;Garth Powis

  • Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.

    Margareta Berggren;Alfred Gallegos;John R. Gasdaska;Pamela Y. Gasdaska

  • Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling.

    Nathan T Ihle;Ryan Williams;Sherry Chow;Wade Chew

  • Hypoxia inducible factor-1α as a cancer drug target

    Garth Powis;Lynn Kirkpatrick

  • Metabolism and reactions of quinoid anticancer agents

    Garth Powis

  • Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α

    Sarah Welsh;Ryan Williams;Lynn Kirkpatrick;Gillian Paine-Murrieta

  • Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α

    Mei Yee Koh;Taly Spivak-Kroizman;Sara Venturini;Sarah Welsh

  • The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

    Sarah J. Welsh;Ryan R. Williams;Anne Birmingham;David J. Newman

  • Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo

    Amanda Baker;Claire M. Payne;Margaret M. Briehl;Garth Powis

  • Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.

    G Powis;M J Seewald;C Gratas;D Melder

  • Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

    Nathan T. Ihle;Robert Lemos;Peter Wipf;Adly Yacoub

  • Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

    Muling Mao;Feng Tian;John M. Mariadason;Chun C. Tsao

  • Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

    A. F. Howie;L. M. Forrester;M. J. Glancey;J. J. Schlager

  • Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival.

    Jennifer Raffel;Achyut K. Bhattacharyya;Alfred Gallegos;Haiyan Cui

  • Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.

    Larisa Nonn;Margareta Berggren;Garth Powis

  • Cloning and sequencing of a human thioredoxin reductase

    Pamela Y. Gasdaska;John R. Gasdaska;Shawn Cochran;Garth Powis

Frequent Co-Authors

Lars Engman
Lars Engman Uppsala University
Scott Kopetz
Scott Kopetz The University of Texas MD Anderson Cancer Center
Robert C. Liddington
Robert C. Liddington Discovery Institute
Robert T. Abraham
Robert T. Abraham Pfizer (United States)
Moses Rodriguez
Moses Rodriguez Mayo Clinic
William R. Montfort
William R. Montfort University of Arizona
Peter Wipf
Peter Wipf University of Pittsburgh
Hyun Cheol Chung
Hyun Cheol Chung Yonsei University
Han Liang
Han Liang The University of Texas MD Anderson Cancer Center

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