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Biology and Biochemistry

D-Index
84
Citations
23722
World Ranking
3340
National Ranking
253

Overview

Katja Becker is affiliated with the University of Giessen in Germany, working primarily in the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research spans several subfields, including Molecular Biology, Public Health, Environmental and Occupational Health, Materials Chemistry, Epidemiology, and Parasitology.

The research topics addressed in their work focus on various aspects of infectious diseases and molecular biochemistry. Key topics include:

  • Redox biology and oxidative stress
  • Malaria Research and Control
  • Parasites and Host Interactions
  • Research on Leishmaniasis Studies
  • Mosquito-borne diseases and control
  • Drug Transport and Resistance Mechanisms
  • Crystallization and Solubility Studies

Katja Becker has contributed to journals and publication venues with multiple papers appearing in bioRxiv (Cold Spring Harbor Laboratory), The Cambridge Structural Database, European Journal of Medicinal Chemistry, ACS Infectious Diseases, and Biological Chemistry.

Frequent collaborators in their research include Stefan Rahlfs, Christina Brandstädter, Kim C. Heimsch, Melissa Dillenberger, and Karin Fritz-Wolf.

Among the recent publications are:

  • Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13 (2020, PLoS Pathogens)
  • Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells (2022, ACS Infectious Diseases)
  • Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif (2021, Journal of the American Chemical Society)
  • 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors (2020, European Journal of Medicinal Chemistry)
  • Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically (2022, Nature Communications)

Best Publications

  • The endophytic fungus Piriformospora indica reprograms barley to salt-stress tolerance, disease resistance, and higher yield

    Frank Waller;Beate Achatz;Beate Achatz;Helmut Baltruschat;József Fodor

  • Oxidative stress in malaria parasite-infected erythrocytes: Host-parasite interactions

    Katja Becker;Leann Tilley;Jonathan L. Vennerstrom;David Roberts

  • Human Placenta Thioredoxin Reductase: ISOLATION OF THE SELENOENZYME, STEADY STATE KINETICS, AND INHIBITION BY THERAPEUTIC GOLD COMPOUNDS *

    Stephan Gromer;L. David Arscott;Charles H. Williams;R. Heiner Schirmer

  • The thioredoxin system—From science to clinic

    Stephan Gromer;Sabine Urig;Katja Becker

  • Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster

    Stefan M. Kanzok;Stefan M. Kanzok;Anke Fechner;Anke Fechner;Holger Bauer;Julia K. Ulschmid

  • Thioredoxin reductase as a pathophysiological factor and drug target

    Katja Becker;Stephan Gromer;R. Heiner Schirmer;Sylke Müller

  • On the potential of thioredoxin reductase inhibitors for cancer therapy.

    Sabine Urig;Katja Becker

  • Thioredoxin reductase two modes of catalysis have evolved.

    C H Williams;L D Arscott;S Müller;B W Lennon

  • Molecular genetics of attention-deficit/hyperactivity disorder: an overview.

    Tobias Banaschewski;Katja Becker;Susann Scherag;Barbara Franke

  • Adaptation of Energy Metabolism in Breast Cancer Brain Metastases

    Emily I. Chen;Johannes Hewel;Joseph S. Krueger;Claire Tiraby

  • The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

    L. David Arscott;Stephan Gromer;R. Heiner Schirmer;Katja Becker

  • The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited

    S M Kanzok;R H Schirmer;I Turbachova;R Iozef

  • Methylene blue as an antimalarial agent.

    R. Heiner Schirmer;Boubacar Coulibaly;August Stich;Michael Scheiwein

  • Interacting Effects of the Dopamine Transporter Gene and Psychosocial Adversity on Attention-Deficit/ Hyperactivity Disorder Symptoms Among 15-Year-Olds From a High-Risk Community Sample

    Manfred Laucht;Markus H. Skowronek;Katja Becker;Martin H. Schmidt

  • Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases.

    Sabine Urig;Karin Fritz-Wolf;Régis Réau;Christel Herold-Mende

  • Impact of age at first drink on vulnerability to alcohol-related problems: Testing the marker hypothesis in a prospective study of young adults

    Arlette F. Buchmann;Brigitte Schmid;Dorothea Blomeyer;Katja Becker

  • Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum.

    Kathrin Buchholz;R. Heiner Schirmer;Jana K. Eubel;Monique B. Akoachere

  • The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase.

    Helena Sztajer;Benoit Gamain;Klaus-Dieter Aumann;Christian Slomianny

  • Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers

    K Becker;Savvas Savvides;M Keese;Rh Schirmer

  • Compartmentation of Redox Metabolism in Malaria Parasites

    Sebastian Kehr;Nicole Sturm;Stefan Rahlfs;Jude M. Przyborski

Frequent Co-Authors

R. Heiner Schirmer
R. Heiner Schirmer Heidelberg University
Lars Bode
Lars Bode University of California, San Diego
Martin H. Schmidt
Martin H. Schmidt Heidelberg University
John R. Yates
John R. Yates Scripps Research Institute
Sylke Müller
Sylke Müller University of Glasgow
Charles H. Williams
Charles H. Williams University of Michigan–Ann Arbor
Ertan Mayatepek
Ertan Mayatepek Heinrich Heine University Düsseldorf
Christine M. Freitag
Christine M. Freitag Goethe University Frankfurt
Sergio Wittlin
Sergio Wittlin Swiss Tropical and Public Health Institute
Christel Herold-Mende
Christel Herold-Mende Heidelberg University

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