R. Luise Krauth-Siegel

Overview

Best Publications

• Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.

  R. Luise Krauth-Siegel;Marcelo A. Comini

  479
  Citations

• Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

  S. Krieger;W. Schwarz;M. R. Ariyanayagam;A. H. Fairlamb

  432
  Citations

• Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia.

  R. Luise Krauth-Siegel;Holger Bauer;R. Heiner Schirmer

  413
  Citations

• 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

  L Salmon-Chemin;E Buisine;Yardley;S Kohler

  358
  Citations

• Disulfide‐Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

  R. Heiner Schirmer;Joachim G. Müller;R. Luise Krauth‐Siegel

  299
  Citations

• Thiol-based redox metabolism of protozoan parasites

  Sylke Müller;Eva Liebau;Rolf D. Walter;R.Luise Krauth-Siegel

  296
  Citations

• Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.

  R. Luise Krauth-Siegel;Burkhard Enders;Graeme B. Henderson;Alan H. Fairlamb

  263
  Citations

• Glutathione reductase from human erythrocytes. The sequences of the NADPH domain and of the interface domain.

  R. Luise Krauth-Siegel;Mansoor Saleh;Renate Untucht-Grau;R. Heiner Schirmer

  262
  Citations

• Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets.

  Lucía Otero;Marisol Vieites;Lucía Boiani;Ana Denicola

  212
  Citations

• Enzymatic reduction studies of nitroheterocycles

  Cécile Viodé;Nadir Bettache;Narimantas Cenas;R.Luise Krauth-Siegel

  209
  Citations

• Trypanothione-dependent Synthesis of Deoxyribonucleotides by Trypanosoma brucei Ribonucleotide Reductase

  Matthias Dormeyer;Nina Reckenfelderbäumer;Heike Lüdemann;R. Luise Krauth-Siegel

  158
  Citations

• Crystal structure of the Trypanosoma cruzi trypanothione reductase-mepacrine complex

  Elke M. Jacoby;Elke M. Jacoby;Ilme Schlichting;Christina B. Lantwin;Wolfgang Kabsch

  150
  Citations

• Trypanosoma brucei tryparedoxin, a thioredoxin-like protein in African trypanosomes

  Heike Lüdemann;Matthias Dormeyer;Christian Sticherling;Dirk Stallmann

  138
  Citations

• Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei.

  Sanjay K. Shahi;R. Luise Krauth-Siegel;Christine E. Clayton

  135
  Citations

• Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase.

  Klaus Blumenstiel;Ralf Schöneck;Vanessa Yardley;Simon L. Croft

  132
  Citations

• Interaction of a glutathione S-conjugate with glutathione reductase. Kinetic and X-ray crystallographic studies.

  Manfred Bilzer;R. Luise Krauth-Siegel;R. Heiner Schirmer;Theo P. M. Akerboom

  123
  Citations

• Glyoxalase II of African Trypanosomes Is Trypanothione-dependent

  Thorsten Irsch;R. Luise Krauth-Siegel

  120
  Citations

• Substrate Specificity, Localization, and Essential Role of the Glutathione Peroxidase-type Tryparedoxin Peroxidases in Trypanosoma brucei

  Tanja Schlecker;Armin Schmidt;Natalie Dirdjaja;Frank Voncken

  118
  Citations

• A Second Class of Peroxidases Linked to the Trypanothione Metabolism

  Henning Hillebrand;Armin Schmidt;R. Luise Krauth-Siegel

  115
  Citations

• Low-Molecular-Mass Antioxidants in Parasites

  R Luise Krauth-Siegel;Alejandro E Leroux

  114
  Citations