Gene M. Shearer mainly investigates Immunology, Immune system, Virology, Interleukin 2 and Cytokine. His Immunology research is multidisciplinary, relying on both Cytotoxic T cell and Acquired immunodeficiency syndrome. The study incorporates disciplines such as Molecular biology, CD80 and Antigen in addition to Immune system.
His Virology research incorporates themes from Immune dysregulation, Antibody and Immunity. His Interleukin 2 study also includes fields such as
His primary areas of study are Immunology, Immune system, Virology, Cytotoxic T cell and Antigen. In his study, Viral disease is strongly linked to Acquired immunodeficiency syndrome, which falls under the umbrella field of Immunology. The concepts of his Immune system study are interwoven with issues in Cytokine and Immunopathology.
Gene M. Shearer interconnects Immunity, Peripheral blood mononuclear cell, Human leukocyte antigen, Interleukin 2 and Antibody in the investigation of issues within Virology. Gene M. Shearer combines subjects such as Molecular biology, Effector and Spleen with his study of Cytotoxic T cell. The Molecular biology study combines topics in areas such as Cell and Gene.
His primary areas of investigation include Immunology, Virology, Immune system, T cell and Cytotoxic T cell. His Immunology study often links to related topics such as Acquired immunodeficiency syndrome. His work carried out in the field of Virology brings together such families of science as Amifostine and HIV vaccine.
His work on Interleukin 2, Cellular immunity, Acquired immune system and Innate immune system as part of general Immune system research is frequently linked to Indoleamine 2,3-dioxygenase, thereby connecting diverse disciplines of science. His studies in T cell integrate themes in fields like CD80 and Cell biology. His research investigates the connection with Cytotoxic T cell and areas like Molecular biology which intersect with concerns in ZAP70.
Gene M. Shearer focuses on Immunology, T cell, Cytotoxic T cell, Immune system and IL-2 receptor. While working on this project, he studies both Immunology and Indoleamine 2,3-dioxygenase. Gene M. Shearer works mostly in the field of Cytotoxic T cell, limiting it down to concerns involving Molecular biology and, occasionally, Polyclonal antibodies, Western blot, Antibody, Biological activity and Mixed lymphocyte reaction.
His research in Immune system tackles topics such as Antigen which are related to areas like Antigen presentation, Immunity and Viral load. His research integrates issues of T lymphocyte and Cytokine in his study of CD8. His Virus study is concerned with the larger field of Virology.
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Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
Robert C. Gallo;Syed Z. Salahuddin;Mikulas Popovic;Gene M. Shearer.
T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years
R. Michael Blaese;Kenneth W. Culver;A. Dusty Miller;Charles S. Carter.
A TH1→TH2 switch is a critical step in the etiology of HIV infection
Mario Clerici;Gene M. Shearer.
Immunology Today (1993)
Modulation of Inflammation and Immunity by Cyclic AMP
H R Bourne;L M Lichtenstein;K L Melmon;C S Henney.
ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX
Robert Yarchoan;Kent J. Weinhold;H. Kim Lyerly;Edward Gelmann.
The Lancet (1986)
Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases.
Daniel R. Lucey;Mario Clerici;Gene M. Shearer.
Clinical Microbiology Reviews (1996)
Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.
M Clerici;N I Stocks;R A Zajac;R N Boswell.
Journal of Clinical Investigation (1989)
The Th1–Th2 hypothesis of HIV infection: new insights
Mario Clerici;Gene M. Shearer.
Immunology Today (1994)
Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes
G. M. Shearer.
European Journal of Immunology (1974)
Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts
R. Kiessling;R. Kiessling;Paula S. Hochman;O. Haller;G. M. Shearer.
European Journal of Immunology (1977)
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