What is he best known for?
The fields of study he is best known for:
- Immune system
- Gene
- Antibody
Gene M. Shearer mainly investigates Immunology, Immune system, Virology, Interleukin 2 and Cytokine.
His Immunology research is multidisciplinary, relying on both Cytotoxic T cell and Acquired immunodeficiency syndrome.
The study incorporates disciplines such as Molecular biology, CD80 and Antigen in addition to Immune system.
His Virology research incorporates themes from Immune dysregulation, Antibody and Immunity.
His Interleukin 2 study also includes fields such as
- T helper cell which connect with Asymptomatic and Antigen-presenting cell,
- Interferon gamma which connect with Lymphokine.
His Cytokine research is multidisciplinary, incorporating perspectives in Apoptosis and Programmed cell death.
His most cited work include:
- Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS (2948 citations)
- A TH1→TH2 switch is a critical step in the etiology of HIV infection (1279 citations)
- T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years (1193 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of study are Immunology, Immune system, Virology, Cytotoxic T cell and Antigen.
In his study, Viral disease is strongly linked to Acquired immunodeficiency syndrome, which falls under the umbrella field of Immunology.
The concepts of his Immune system study are interwoven with issues in Cytokine and Immunopathology.
Gene M. Shearer interconnects Immunity, Peripheral blood mononuclear cell, Human leukocyte antigen, Interleukin 2 and Antibody in the investigation of issues within Virology.
Gene M. Shearer combines subjects such as Molecular biology, Effector and Spleen with his study of Cytotoxic T cell.
The Molecular biology study combines topics in areas such as Cell and Gene.
He most often published in these fields:
- Immunology (77.75%)
- Immune system (35.86%)
- Virology (34.29%)
What were the highlights of his more recent work (between 2000-2018)?
- Immunology (77.75%)
- Virology (34.29%)
- Immune system (35.86%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Immunology, Virology, Immune system, T cell and Cytotoxic T cell.
His Immunology study often links to related topics such as Acquired immunodeficiency syndrome.
His work carried out in the field of Virology brings together such families of science as Amifostine and HIV vaccine.
His work on Interleukin 2, Cellular immunity, Acquired immune system and Innate immune system as part of general Immune system research is frequently linked to Indoleamine 2,3-dioxygenase, thereby connecting diverse disciplines of science.
His studies in T cell integrate themes in fields like CD80 and Cell biology.
His research investigates the connection with Cytotoxic T cell and areas like Molecular biology which intersect with concerns in ZAP70.
Between 2000 and 2018, his most popular works were:
- Cutting Edge: The Prevalence of Regulatory T Cells in Lymphoid Tissue Is Correlated with Viral Load in HIV-Infected Patients (319 citations)
- HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. (297 citations)
- Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology (295 citations)
In his most recent research, the most cited papers focused on:
- Immune system
- Gene
- Internal medicine
Gene M. Shearer focuses on Immunology, T cell, Cytotoxic T cell, Immune system and IL-2 receptor.
While working on this project, he studies both Immunology and Indoleamine 2,3-dioxygenase.
Gene M. Shearer works mostly in the field of Cytotoxic T cell, limiting it down to concerns involving Molecular biology and, occasionally, Polyclonal antibodies, Western blot, Antibody, Biological activity and Mixed lymphocyte reaction.
His research in Immune system tackles topics such as Antigen which are related to areas like Antigen presentation, Immunity and Viral load.
His research integrates issues of T lymphocyte and Cytokine in his study of CD8.
His Virus study is concerned with the larger field of Virology.
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