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D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
11003
World Ranking
16597
National Ranking
1157

Overview

Thomas Ruppert is affiliated with Heidelberg University in Germany. Their research spans biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, cell biology, immunology, public health, environmental and occupational health, and oncology.

The scientist has contributed extensively to topics including ubiquitin and proteasome pathways, glycosylation and glycoproteins research, peptidase inhibition and analysis, muscle physiology and disorders, Hippo pathway signaling and YAP/TAZ, research on Trypanosoma species and related implications, as well as studies on leishmaniasis.

Their publication record includes papers in various well-known venues, with a frequent presence in bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Frontiers in Immunology, International Journal of Molecular Sciences, and Zeitschrift für Gastroenterologie.

Recent papers by Thomas Ruppert include the following:

  • A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver, 2021, Developmental Cell
  • Cotranslational N-degron masking by acetylation promotes proteome stability in plants, 2022, Nature Communications
  • High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation, 2022, Nature Communications
  • Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation, 2020, Frontiers in Immunology
  • Potential and Challenges of Harmonizing 40 Years of AVHRR Data: The TIMELINE Experience, 2021, Remote Sensing

Collaborations form a significant part of their work. Frequent coauthors include Roman Sakson, Christian Thiel, Renata Blatnik, Sabine Merker, and Laura Armbruster.

Best Publications

  • The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

    Gerd Multhaup;Andrea Schlicksupp;Lars Hesse;Dirk Beher

  • Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

    Mirko C Sobotta;Willy Liou;Sarah Stöcker;Deepti Talwar

  • Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

    Thomas Stanislawski;Ralf-Holger Voss;Carina Lotz;Elena Sadovnikova

  • Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.

    B Boes;H Hengel;T Ruppert;G Multhaup

  • Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

    Tobias P. Dick;Thomas Ruppert;Marcus Groettrup;Peter M. Kloetzel

  • Reactive oxygen species and Alzheimer's disease

    Gerd Multhaup;Thomas Ruppert;Andrea Schlicksupp;Lars Hesse

  • The Interferon-Gamma-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

    Marcus Groettrup;Thomas Ruppert;Lothar Kuehn;Michael Seeger

  • Analysis of the Arabidopsis O-Acetylserine(thiol)lyase Gene Family Demonstrates Compartment-Specific Differences in the Regulation of Cysteine Synthesis

    Corinna Heeg;Cordula Kruse;Ricarda Jost;Michael Gutensohn

  • Different proteasome subtypes in a single tissue exhibit different enzymatic properties

    Burkhardt Dahlmann;Thomas Ruppert;Lothar Kuehn;Simone Merforth

  • A Single Residue Exchange Within a Viral CTL Epitope Alters Proteasome-Mediated Degradation Resulting in Lack of Antigen Presentation

    Ferry Ossendorp;Maren Eggers;Anne Neisig;Thomas Ruppert

  • Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling.

    Stefan Kemmler;Manuel Stach;Maria Knapp;Jennifer Ortiz

  • A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation

    Sarah Stöcker;Michael Maurer;Thomas Ruppert;Tobias P Dick

  • Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model

    Claudio Kupfahl;Thorsten Heinekamp;Gernot Geginat;Thomas Ruppert

  • Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes.

    Alice J.A.M. Sijts;Thomas Ruppert;Barbara Rehermann;Marion Schmidt

  • Hepatitis C virus mutation affects proteasomal epitope processing

    Ulrike Seifert;Heike Liermann;Vito Racanelli;Anne Halenius

  • Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.

    Gerd Multhaup;Thomas Ruppert;Andrea Schlicksupp;Lars Hesse

  • Comparative proteomics of glycosomes from bloodstream form and procyclic culture form Trypanosoma brucei brucei.

    Claudia Colasante;Margrit Ellis;Thomas Ruppert;Frank Voncken

  • Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape.

    Hartmut Hengel;Pero Lučin;Stipan Jonjić;T. Ruppert

  • The cleavage preference of the proteasome governs the yield of antigenic peptides.

    M Eggers;B Boes-Fabian;T Ruppert;P M Kloetzel

  • The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope

    Matthias Theobald;Thomas Ruppert;Ulrike Kuckelkorn;Javier Hernandez

Frequent Co-Authors

Ulrich H. Koszinowski
Ulrich H. Koszinowski Ludwig-Maximilians-Universität München
Peter-M. Kloetzel
Peter-M. Kloetzel Charité - University Medicine Berlin
Gerd Multhaup
Gerd Multhaup McGill University
Joachim Wittbrodt
Joachim Wittbrodt Heidelberg University
R. Luise Krauth-Siegel
R. Luise Krauth-Siegel Heidelberg University
Thierry Soldati
Thierry Soldati University of Geneva
Hartmut Hengel
Hartmut Hengel University of Freiburg
Konrad Beyreuther
Konrad Beyreuther Heidelberg University
Tobias P. Dick
Tobias P. Dick Heidelberg University
Alice J. A. M. Sijts
Alice J. A. M. Sijts Utrecht University

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