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Marcus Groettrup

Marcus Groettrup

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
20124
World Ranking
3761
National Ranking
279

Overview

Marcus Groettrup is affiliated with the University of Konstanz in Germany and specializes in research areas spanning Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine. Their work encompasses specific subfields such as Immunology, Molecular Biology, Epidemiology, Oncology, and Transplantation.

Their research topics predominantly focus on the ubiquitin and proteasome pathways, interferon and immune responses, immune cell function and interaction, immunotherapy and immune responses, endoplasmic reticulum stress and disease, glycosylation and glycoproteins research, and immune response and inflammation.

Recent publications by Groettrup include the following papers:

  • PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy, 2021, Nature Communications
  • On the Role of the Immunoproteasome in Protein Homeostasis, 2021, Cells
  • Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy, 2021, Cell Reports
  • The ubiquitin-like modifier FAT10 - much more than a proteasome-targeting signal, 2020, Journal of Cell Science
  • Recent insights how combined inhibition of immuno/proteasome subunits enables therapeutic efficacy, 2020, Genes and Immunity

Frequent co-authors collaborating with Groettrup include:

  • Michael Basler
  • Annette Aichem
  • Dennis J. Horvath
  • Jacques Rohayem
  • Nicola Catone

The scientist's work has been published multiple times in venues such as:

  • Journal of Cell Science
  • European Journal of Immunology
  • Journal of Visualized Experiments
  • Nature Communications
  • Cells

Best Publications

  • Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance.

    Andreas Limmer;Jutta Ohl;Christian Kurts;Hans-Gustaf Ljunggren

  • A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

    Tony Muchamuel;Michael Basler;Monette A Aujay;Erika Suzuki

  • Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

    Eva M. Huber;Michael Basler;Ricarda Schwab;Wolfgang Heinemeyer

  • Analysis and expression of a cloned pre-T cell receptor gene.

    C Saint-Ruf;K Ungewiss;M Groettrup;L Bruno

  • A role for the proteasome regulator PA28α in antigen presentation

    Marcus Groettrup;Andrea Soza;Maren Eggers;Lothar Kuehn

  • Proteasomes in immune cells: more than peptide producers?

    Marcus Groettrup;Christopher J. Kirk;Michael Basler

  • Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

    Tobias P. Dick;Thomas Ruppert;Marcus Groettrup;Peter M. Kloetzel

  • TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses

    Eva Schlosser;Marc Mueller;Stefan Fischer;Sameh Basta

  • An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.

    P André;M Groettrup;P Klenerman;R de Giuli

  • The Interferon-Gamma-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

    Marcus Groettrup;Thomas Ruppert;Lothar Kuehn;Michael Seeger

  • Peptide antigen production by the proteasome: complexity provides efficiency

    Marcus Groettrup;Andrea Soza;Ulrike Kuckelkorn;Peter-M. Kloetzel

  • The immunoproteasome in antigen processing and other immunological functions.

    Michael Basler;Christopher J Kirk;Marcus Groettrup

  • Prevention of experimental colitis by a selective inhibitor of the immunoproteasome.

    Michael Basler;Maya Dajee;Carlo Moll;Marcus Groettrup

  • PLGA microspheres for improved antigen delivery to dendritic cells as cellular vaccines.

    Ying Waeckerle-Men;Marcus Groettrup

  • Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

    Hannah Gola;Hannah Gola;Harald Engler;Annette Sommershof;Hannah Adenauer

  • A THIRD INTERFERON-GAMMA -INDUCED SUBUNIT EXCHANGE IN THE 20S PROTEASOME

    Marcus Groettrup;Regine Kraft;Susanne Kostka;Sybille Standera

  • Prostaglandin E2 Is Generally Required for Human Dendritic Cell Migration and Exerts Its Effect via EP2 and EP4 Receptors

    Daniel F. Legler;Petra Krause;Elke Scandella;Eva Singer

  • Incorporation of major histocompatibility complex--encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-gamma.

    Ulrike Kuckelkorn;Stefan Frentzel;Regine Kraft;Susanne Kostka

  • Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation.

    Annalisa Macagno;Michel Gilliet;Federica Sallusto;Antonio Lanzavecchia

  • FAT10, a ubiquitin-independent signal for proteasomal degradation

    Mark Steffen Hipp;Birte Kalveram;Shahri Raasi;Shahri Raasi;Marcus Groettrup

Frequent Co-Authors

Maries van den Broek
Maries van den Broek University of Zurich
Bruno Gander
Bruno Gander ETH Zurich
Harald Engler
Harald Engler Essen University Hospital
Christopher J. Kirk
Christopher J. Kirk Kezar Life Sciences
Michael Przybylski
Michael Przybylski University of Konstanz
Iris-Tatjana Kolassa
Iris-Tatjana Kolassa University of Ulm
Burkhard Ludewig
Burkhard Ludewig University of Zurich
Peter-M. Kloetzel
Peter-M. Kloetzel Charité - University Medicine Berlin
Michael E. Cheetham
Michael E. Cheetham University College London
Horst Weller
Horst Weller Universität Hamburg

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