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Alice J. A. M. Sijts

Alice J. A. M. Sijts

D-Index & Metrics

Immunology

D-Index
43
Citations
6475
World Ranking
4851
National Ranking
190

Overview

Alice J. A. M. Sijts is affiliated with Utrecht University in the Netherlands and has made contributions across multiple fields related to biomedical research. Their work predominantly intersects medicine, immunology and microbiology, as well as biochemistry, genetics, and molecular biology.

The scientist's research subfields include immunology, molecular biology, radiology, nuclear medicine and imaging, oncology, and microbiology. Their research topics focus on areas such as monoclonal and polyclonal antibodies research, immunotherapy and immune responses, CAR-T cell therapy research, vaccines and immunoinformatics approaches, infant nutrition and health, COVID-19 impact on reproduction, and neonatal respiratory health research.

Recent publications by Alice J. A. M. Sijts include the following:

  • Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy, 2020, Journal of Cancer Research and Clinical Oncology
  • Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses, 2021, Journal of Extracellular Vesicles
  • Hsp70 and NF-kB Mediated Control of Innate Inflammatory Responses in a Canine Macrophage Cell Line, 2020, International Journal of Molecular Sciences
  • The Function of Immunoproteasomes-An Immunologists' Perspective, 2021, Cells
  • Opportunities and challenges of bi-specific antibodies, 2022, International review of cell and molecular biology

The scientist has published multiple articles in venues such as the Journal of Immunological Methods, Journal of Cancer Research and Clinical Oncology, Journal of Extracellular Vesicles, International Journal of Molecular Sciences, and Cells.

Frequent coauthors collaborating with Alice J. A. M. Sijts include:

  • Shuyu Huang
  • Aina Segués
  • Dietmar M. Zaiss
  • Sander M. J. van Duijnhoven
  • Andrea van Elsas

Best Publications

  • Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

    Dietmar M.W. Zaiss;Jorg van Loosdregt;Andrea Gorlani;Cornelis P.J. Bekker

  • Efficient Identification of Novel HLA-A * 0201-presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen PRAME by Proteasome-mediated Digestion Analysis

    Jan H. Kessler;Nico J. Beekman;Sandra A. Bres-Vloemans;Pauline Verdijk

  • The role of the proteasome in the generation of MHC class I ligands and immune responses

    E. J. A. M. Sijts;P.-M. Kloetzel

  • Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

    Jorg van Loosdregt;Veerle Fleskens;Juan Fu;Arjan B. Brenkman

  • Canonical Wnt signaling negatively modulates regulatory T cell function

    Jorg van Loosdregt;Veerle Fleskens;Machteld M. Tiemessen;Michal Mokry

  • A Single Residue Exchange Within a Viral CTL Epitope Alters Proteasome-Mediated Degradation Resulting in Lack of Antigen Presentation

    Ferry Ossendorp;Maren Eggers;Anne Neisig;Thomas Ruppert

  • Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes.

    Alice J.A.M. Sijts;Thomas Ruppert;Barbara Rehermann;Marion Schmidt

  • Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences.

    A Neisig;J Roelse;A J Sijts;F Ossendorp

  • Hepatitis C virus mutation affects proteasomal epitope processing

    Ulrike Seifert;Heike Liermann;Vito Racanelli;Anne Halenius

  • The role of the proteasome activator PA28 in MHC class I antigen processing.

    Alice Sijts;Yuancheng Sun;Katarina Janek;Sylvie Kral

  • MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells.

    Alice J. A. M. Sijts;Sybille Standera;René E. M. Toes;Thomas Ruppert

  • Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or Pa28

    Thorbald van Hall;Alice Sijts;Marcel Camps;Rienk Offringa

  • PI31 is a modulator of proteasome formation and antigen processing

    Dietmar M. W. Zaiss;Sybille Standera;Peter-M. Kloetzel;Alice J. A. M. Sijts

  • MHC class I antigen processing of Listeria monocytogenes proteins : Implications for dominant and subdominant CTL responses

    Eric G. Pamer;Alice J.A.M. Sijts;Merceditas S. Villanueva;Dirk H. Busch

  • Listeriolysin is processed efficiently into an MHC class I-associated epitope in Listeria monocytogenes-infected cells.

    M. S. Villanueva;A. J. A. M. Sijts;E. G. Pamer

  • TWO LISTERIA MONOCYTOGENES CTL EPITOPES ARE PROCESSED FROM THE SAME ANTIGEN WITH DIFFERENT EFFICIENCIES

    A. J. A. M. Sijts;A. Neisig;J. Neefjes;E. G. Pamer

  • Expression of the Proteasome Activator PA28 Rescues the Presentation of a Cytotoxic T Lymphocyte Epitope on Melanoma Cells

    Yuansheng Sun;Alice J A M Sijts;Mingxia Song;Katharina Janek

  • Enhanced Intracellular Dissociation of Major Histocompatibility Complex Class I-associated Peptides: A Mechanism for Optimizing the Spectrum of Cell Surface-Presented Cytotoxic T Lymphocyte Epitopes

    Alice J.A.M. Sijts;Eric G. Pamer

  • Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site

    Nico J. Beekman;Peter A. van Veelen;Thorbald van Hall;Anne Neisig

  • Hepatitis C virus mutation affects proteasomal epitope processing

    Unknown

  • Immunodominant mink cell focus-inducing murine leukemia virus (MuLV)-encoded CTL epitope, identified by its MHC class I-binding motif, explains MuLV-type specificity of MCF-directed cytotoxic T lymphocytes.

    A. J. A. M. Sijts;F. Ossendorp;E. A. M. Mengede;P. J. Van Den Elsen

  • Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.

    Carlos Munoz Minutti;Sebastian Drube;Natalie Blair;Christian Schwartz

Frequent Co-Authors

Peter-M. Kloetzel
Peter-M. Kloetzel Charité - University Medicine Berlin
Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Willem van Eden
Willem van Eden Utrecht University
Cornelis J. M. Melief
Cornelis J. M. Melief ISA Pharmaceuticals (Netherlands)
Eric G. Pamer
Eric G. Pamer Memorial Sloan Kettering Cancer Center
Victor P.M.G. Rutten
Victor P.M.G. Rutten University of Pretoria
Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
David J. Topham
David J. Topham University of Rochester Medical Center
Paul J. Coffer
Paul J. Coffer Utrecht University
Thomas Ruppert
Thomas Ruppert Heidelberg University

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