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Microbiology

D-Index
103
Citations
56454
World Ranking
342
National Ranking
158

Overview

Kenneth L. Rock is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily focuses on immunology and related biomedical fields, addressing several key aspects of immune responses, particularly in the context of cancer and antigen presentation.

The main fields of study for Rock include Immunology and Microbiology with 17 publications, and Medicine with 12 publications. Within these fields, their work spans important subfields such as Immunology, Oncology, Molecular Biology, Immunology and Allergy, and Radiology, Nuclear Medicine and Imaging.

Rock's research concentrates on several main topics, including:

  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Inflammasome and immune disorders
  • Cell Adhesion Molecules Research

Recent significant papers authored or co-authored by Rock cover themes around antigen presentation and immune evasion mechanisms. These include:

  • Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation, 2021, Frontiers in Immunology
  • Cross-presentation of exogenous antigens on MHC I molecules, 2020, Current Opinion in Immunology
  • Tumor immune evasion through loss of MHC class-I antigen presentation, 2023, Current Opinion in Immunology
  • Pathways of MHC I cross-presentation of exogenous antigens, 2023, Seminars in Immunology
  • Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation, 2022, Proceedings of the National Academy of Sciences

Rock frequently collaborates with several researchers, with notable co-authors including Jeff D. Colbert, Friedrich M. Cruz, Laura Alejandra Ariza Orellano, Jiann-Jyh Lai, and Karthik Dhatchinamoorthy.

Among the publication venues where Rock's work appears multiple times are Current Opinion in Immunology and Proceedings of the National Academy of Sciences. Other venues include Frontiers in Immunology, Seminars in Immunology, and Journal of Experimental & Clinical Cancer Research.

Best Publications

  • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

    Peter Duewell;Hajime Kono;Katey J. Rayner;Katey J. Rayner;Cherilyn M. Sirois

  • Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

    Kenneth L. Rock;Colette Gramm;Lisa Rothstein;Karen Clark

  • Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

    Veit Hornung;Franz G. Bauernfeind;Annett Halle;Eivind O. Samstad;Eivind O. Samstad

  • How dying cells alert the immune system to danger

    Hajime Kono;Kenneth L. Rock

  • Molecular identification of a danger signal that alerts the immune system to dying cells

    Yan Shi;James E. Evans;Kenneth L. Rock

  • Degradation of cell proteins and the generation of MHC class I-presented peptides.

    Kenneth L. Rock;Alfred L. Goldberg

  • Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

    Z Shen;G Reznikoff;G Dranoff;K L Rock

  • A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules

    M. Kovacsovics-Bankowski;K. L. Rock

  • The Inflammatory Response to Cell Death

    Kenneth L. Rock;Hajime Kono

  • Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

    Chun-Jen Chen;Hajime Kono;Douglas Golenbock;George Reed

  • The Sterile Inflammatory Response

    Kenneth L. Rock;Eicke Latz;Fernando Ontiveros;Hajime Kono

  • Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation.

    Karthik Dhatchinamoorthy;Jeff D. Colbert;Kenneth L. Rock

  • Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages

    Magdalena Kovacsovics-Bankowski;Karen Clark;Baruj Benacerraf;Kenneth L. Rock

  • Antigen processing and presentation by the class I major histocompatibility complex.

    Ian A. York;Kenneth L. Rock

  • Present Yourself! By MHC Class I and MHC Class II Molecules

    Kenneth L. Rock;Eric Reits;Jacques Neefjes;Jacques Neefjes

  • Proteolysis, proteasomes and antigen presentation

    Alfred L. Goldberg;Kenneth L. Rock

  • γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

    Maria E Gaczynska;Kenneth L. Rock;Alfred L. Goldberg

  • Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

    Luis J. Sigal;Shane Crotty;Raul Andino;Kenneth L. Rock

  • An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.

    Tomo Saric;Shih-Chung Chang;Akira Hattori;Ian A. York

  • A new foreign policy: MHC class I molecules monitor the outside world

    Kenneth L. Rock

  • Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (Nature (2010) 464 (1357-1361))

    Peter Duewell;Hajime Kono;Katey J. Rayner;Cherilyn M. Sirois

Frequent Co-Authors

Baruj Benacerraf
Baruj Benacerraf Harvard University
Alfred L. Goldberg
Alfred L. Goldberg Harvard University
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Edward T.H. Yeh
Edward T.H. Yeh University of Missouri
Tomo Saric
Tomo Saric University of Cologne
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School
Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
Kathryn J. Moore
Kathryn J. Moore New York University Langone Medical Center
Veit Hornung
Veit Hornung Ludwig-Maximilians-Universität München
Andrew J. Murphy
Andrew J. Murphy St. Jude Children's Research Hospital

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