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Axel A. Brakhage

Axel A. Brakhage

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Microbiology
Germany
2023

D-Index & Metrics

Microbiology

D-Index
100
Citations
33952
World Ranking
415
National Ranking
26

Research.com Recognitions

  • 2023 - Research.com Microbiology in Germany Leader Award
  • 2022 - Research.com Microbiology in Germany Leader Award

Overview

Axel A. Brakhage is affiliated with the Leibniz Association in Germany and primarily conducts research in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work often focuses on subfields such as Molecular Biology, Infectious Diseases, Epidemiology, Plant Science, and Pharmacology.

The main topics they explore include:

  • Antifungal resistance and susceptibility
  • Fungal Infections and Studies
  • Fungal and yeast genetics research
  • Microbial Natural Products and Biosynthesis
  • Peptidase Inhibition and Analysis
  • Mycotoxins in Agriculture and Food
  • Plant-Microbe Interactions and Immunity

Brakhage has contributed to research published in several scientific venues, with frequent publications appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • mBio
  • Nature Communications
  • Journal of Fungi
  • microLife

Recent notable papers by Brakhage include:

  • "Fungal iron homeostasis with a focus on Aspergillus fumigatus," 2020, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • "Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity," 2020, Nature Communications
  • "Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA," 2021, mBio
  • "Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin," 2020, eLife
  • "Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn's disease," 2023, Nature Medicine

Brakhage collaborates frequently with other researchers. Their most frequent co-authors include:

  • Olaf Kniemeyer
  • Thomas Krüger
  • Thorsten Heinekamp
  • Peter Hortschansky
  • Zoltán Cseresnyés

Best Publications

  • Regulation of fungal secondary metabolism

    Axel A. Brakhage;Axel A. Brakhage

  • Minimum Information about a Biosynthetic Gene cluster.

    Marnix H. Medema;Marnix H. Medema;Renzo Kottmann;Pelin Yilmaz;Matthew Cummings

  • Fungal secondary metabolites - strategies to activate silent gene clusters.

    Axel A. Brakhage;Volker Schroeckh

  • Surface hydrophobin prevents immune recognition of airborne fungal spores

    Vishukumar Aimanianda;Jagadeesh Bayry;Jagadeesh Bayry;Jagadeesh Bayry;Silvia Bozza;Olaf Kniemeyer

  • Biosynthesis of fungal melanins and their importance for human pathogenic fungi.

    Kim Langfelder;Martin Streibel;Bernhard Jahn;Gerhard Haase

  • Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

    Volker Schroeckh;Kirstin Scherlach;Hans-Wilhelm Nützmann;Ekaterina Shelest

  • Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

    Sebastian Bergmann;Julia Schümann;Kirstin Scherlach;Corinna Lange

  • Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

    Ronald P. de Vries;Robert Riley;Ad Wiebenga;Guillermo Aguilar-Osorio

  • Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

    Sandra Bruns;Olaf Kniemeyer;Olaf Kniemeyer;Mike Hasenberg;Vishukumar Aimanianda

  • The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus.

    Márcia Eliana da Silva Ferreira;Marcia R. V. Z. Kress;Marcela Savoldi;Maria Helena S. Goldman

  • Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans.

    Petra Bacher;Thordis Hohnstein;Eva Beerbaum;Marie Röcker

  • Regulation and Role of Fungal Secondary Metabolites.

    Juliane Macheleidt;Derek J. Mattern;Derek J. Mattern;Juliane Fischer;Juliane Fischer;Tina Netzker;Tina Netzker

  • Identification of a polyketide synthase gene ( pksP ) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence

    K. Langfelder;Bernhard Jahn;Heike Gehringer;Axel Schmidt

  • Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2

    Kathrin Luther;Antonella Torosantucci;Axel A. Brakhage;Jürgen Heesemann

  • Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

    Tina Netzker;Tina Netzker;Juliane Fischer;Juliane Fischer;Jakob Weber;Jakob Weber;Derek J. Mattern;Derek J. Mattern

  • Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.

    Hans-Wilhelm Nützmann;Yazmid Reyes-Dominguez;Kirstin Scherlach;Volker Schroeckh

  • Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi.

    Nicolas Rispail;Darren M Soanes;Cemile Ant;Robert Czajkowski

  • Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans.

    Petra Bacher;Frederik Heinrich;Ulrik Stervbo;Mikalai Nienen

  • HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.

    Markus Schrettl;Nicola Beckmann;John Varga;Thorsten Heinekamp

  • The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model.

    Franziska Lessing;Franziska Lessing;Olaf Kniemeyer;Olaf Kniemeyer;Iwona Wozniok;Juergen Loeffler

  • Additional file 8: of Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

    Ronald de Vries;Robert Riley;Ad Wiebenga;Guillermo Aguilar-Osorio

Frequent Co-Authors

Olaf Kniemeyer
Olaf Kniemeyer Leibniz Association
Thorsten Heinekamp
Thorsten Heinekamp Hans Knöll Institute
Christian Hertweck
Christian Hertweck Friedrich Schiller University Jena
Reinhard Guthke
Reinhard Guthke Leibniz Association
Gustavo H. Goldman
Gustavo H. Goldman Universidade de São Paulo
Hubertus Haas
Hubertus Haas Innsbruck Medical University
Peter F. Zipfel
Peter F. Zipfel Friedrich Schiller University Jena
Gerhard H. Braus
Gerhard H. Braus University of Göttingen
Jean-Paul Latgé
Jean-Paul Latgé University of Crete
Claudio Scazzocchio
Claudio Scazzocchio Imperial College London

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