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Microbiology

D-Index
61
Citations
12042
World Ranking
3023
National Ranking
1200

Overview

Vinay K. Pathak is affiliated with the National Institutes of Health in the United States. Their research spans several interconnected fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Within these areas, Pathak has contributed extensively to Molecular Biology, Virology, Infectious Diseases, Epidemiology, and Biophysics.

Pathak's work primarily focuses on HIV research and treatment, reflected in a significant number of publications on HIV/AIDS drug development and treatment. They also engage in studies related to RNA research and splicing, RNA and protein synthesis mechanisms, RNA modifications and cancer, CRISPR and genetic engineering, as well as cytomegalovirus and herpesvirus research.

Frequent coauthors who have collaborated with Pathak include:

  • Wei-Shau Hu
  • Ryan C. Burdick
  • Olga A. Nikolaitchik
  • Jonathan Rawson
  • Alice Duchon

Pathak's research has been published across multiple scientific journals, with repeated contributions in the following venues:

  • Proceedings of the National Academy of Sciences
  • mBio
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Viruses
  • Journal of Virology

Recent notable papers authored or coauthored by Pathak include:

  • "HIV-1 uncoats in the nucleus near sites of integration," 2020, Proceedings of the National Academy of Sciences
  • "HIV-1 cores retain their integrity until minutes before uncoating in the nucleus," 2021, Proceedings of the National Academy of Sciences
  • "Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CLpro Inhibitors," 2021, Viruses
  • "Visualizing the translation and packaging of HIV-1 full-length RNA," 2020, Proceedings of the National Academy of Sciences
  • "The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores," 2023, Proceedings of the National Academy of Sciences

Best Publications

  • The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs.

    R. J. Kaufman;M. V. Davies;V. K. Pathak;J. W. B. Hershey

  • Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations.

    Vinay K. Pathak;Howard M. Temin

  • Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

    Jean L. Mbisa;Rebekah Barr;James A. Thomas;Nick Vandegraaff

  • A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.

    Hongzhan Xu;Evguenia S. Svarovskaia;Rebekah Barr;Yijun Zhang

  • Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions.

    Vinay K. Pathak;Howard M. Temin

  • Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.

    Evguenia S. Svarovskaia;Hongzhan Xu;Jean L. Mbisa;Rebekah Barr

  • HIV-1 uncoats in the nucleus near sites of integration

    Ryan C Burdick;Chenglei Li;MohamedHusen Munshi;Jonathan M O Rawson

  • Recombinant Origin of the Retrovirus XMRV

    Tobias Paprotka;Krista A. Delviks-Frankenberry;Oya Cingöz;Anthony Martinez

  • Guidelines for naming nonprimate APOBEC3 genes and proteins.

    Rebecca S. LaRue;Valgerdur Andrésdóttir;Yannick Blanchard;Silvestro G. Conticello

  • Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F.

    Rebecca A. Russell;Vinay K. Pathak

  • Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

    Godwin C. G. Pais;Xuechun Zhang;Christophe Marchand;Nouri Neamati

  • High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis.

    Jianbo Chen;Olga Nikolaitchik;Jatinder Singh;Andrew Wright

  • Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them All

    Belete A. Desimmie;Krista A. Delviks-Frankenberrry;Ryan C. Burdick;DongFei Qi

  • Design of Retroviral Vectors and Helper Cells for Gene Therapy

    Wei-Shau Hu;Vinay K. Pathak

  • P Body-Associated Protein Mov10 Inhibits HIV-1 Replication at Multiple Stages

    Ryan Burdick;Jessica L. Smith;Chawaree Chaipan;Yeshitila Friew

  • Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: Balance between RNase H activity and nucleotide excision

    Galina N. Nikolenko;Sarah Palmer;Frank Maldarelli;John W. Mellors

  • Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance.

    Patric Jern;Rebecca A. Russell;Vinay K. Pathak;John M. Coffin

  • Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance.

    Galina N. Nikolenko;Krista A. Delviks-Frankenberry;Sarah Palmer;Frank Maldarelli

  • APOBEC3F and APOBEC3G Inhibit HIV-1 DNA Integration by Different Mechanisms

    Jean L. Mbisa;Wei Bu;Vinay K. Pathak

  • Azido-Containing Diketo Acid Derivatives Inhibit Human Immunodeficiency Virus Type 1 Integrase In Vivo and Influence the Frequency of Deletions at Two-Long-Terminal-Repeat-Circle Junctions

    Evguenia S. Svarovskaia;Rebekah Barr;Xuechun Zhang;Godwin C. G. Pais

  • Retroviral mutation rates and reverse transcriptase fidelity.

    Svarovskaia Es;Cheslock;Zhang Wh;Hu Ws

  • HIV-1 cores retain their integrity until minutes before uncoating in the nucleus

    Chenglei Li;Ryan C. Burdick;Kunio Nagashima;Wei-Shau Hu

Frequent Co-Authors

John M. Coffin
John M. Coffin Tufts University
Frank Maldarelli
Frank Maldarelli National Institutes of Health
Robert J. Gorelick
Robert J. Gorelick National Institutes of Health
Kunio Nagashima
Kunio Nagashima National Institutes of Health
Mary F. Kearney
Mary F. Kearney National Institutes of Health
Eric O. Freed
Eric O. Freed National Institutes of Health
John W. B. Hershey
John W. B. Hershey University of California, Davis
Klaus Strebel
Klaus Strebel National Institutes of Health
Howard M. Temin
Howard M. Temin University of Wisconsin–Madison
Brandon F. Keele
Brandon F. Keele National Institutes of Health

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