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Microbiology

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96
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30465
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518
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238

Medicine

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95
Citations
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Research.com Recognitions

  • 1992 - US President's National Medal of Science "For his demonstration of the existence of RNA-directed DNA synthesis, leading to the discovery of proto-oncogenes within eukaryotic cells and the role of such genes in oncogenesis by viruses and other agents, laying the foundation for our knowledge of the replication of HIV, changing our ideas about evolution, and providing vital technology for genetic engineering and human gene therapy.", Presented by President Bush at a White House ceremony on June 23, 1992.
  • 1990 - Member of the National Academy of Medicine (NAM)
  • 1986 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1975 - Nobel Prize for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell
  • 1974 - Member of the National Academy of Sciences
  • 1974 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 1974 - Canada Gairdner International Award

Overview

Howard M. Temin was affiliated with the University of Wisconsin-Madison in the United States. Their scientific work contributed to the understanding of genetic material and viral interactions within eukaryotic cells.

Temin received several prestigious awards throughout their career. In 1975, they were awarded the Nobel Prize for discoveries concerning the interaction between tumour viruses and the genetic material of the cell.

Other notable recognitions included the Canada Gairdner International Award and the Albert Lasker Award for Basic Medical Research, both awarded in 1974. Temin was also elected as a Member of the National Academy of Sciences in 1974.

Further distinctions included being named a Fellow of the American Association for the Advancement of Science (AAAS) in 1986 and becoming a Member of the National Academy of Medicine (NAM) in 1990.

In 1992, Temin was awarded the US President's National Medal of Science. The citation highlighted their demonstration of the existence of RNA-directed DNA synthesis, which led to the discovery of proto-oncogenes within eukaryotic cells and the role of such genes in oncogenesis by viruses and other agents. This work laid foundational knowledge relevant to the replication of HIV and influenced the fields of evolution, genetic engineering, and human gene therapy. This award was presented by President Bush during a White House ceremony on June 23, 1992.

The scope of their research primarily addressed molecular biology and virology, focusing on the genetic mechanisms that govern virus-cell interactions and oncogenesis.

Best Publications

  • RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

    Howard M. Temin;Satoshi Mizutani

  • Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.

    L M Mansky;H M Temin

  • Retroviral recombination and reverse transcription.

    Wei-Shau Hu;Howard M. Temin

  • Human immunodeficiency viruses.

    John Coffin;Ashley Haase;Jay A. Levy;Luc Montagnier

  • Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture.

    Howard M. Temin;Harry Rubin

  • Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination.

    Wei-Shau Hu;Howard M. Temin

  • RNA-Directed DNA Synthesis and RNA Tumor Viruses

    Howard M. Temin;David Baltimore

  • Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism

    Michael Emerman;Howard M. Temin

  • Standardized and simplified nomenclature for proteins common to all retroviruses.

    J Leis;D Baltimore;J M Bishop;J Coffin

  • A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication-stimulating activity for embryo fibroblasts.

    Norman C. Dulak;Howard M. Temin

  • Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.

    Howard M. Temin

  • Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations.

    Vinay K. Pathak;Howard M. Temin

  • Stimulation by serum of multiplication of stationary chicken cells.

    Howard M. Temin

  • Origin of retroviruses from cellular moveable genetic elements.

    Howard M. Temin

  • Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel.

    K C Wilhelmsen;K Eggleton;H M Temin

  • Sequence of retrovirus provirus resembles that of bacterial transposable elements

    Kunitada Shimotohno;Satoshi Mizutani;Howard M. Temin

  • Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus

    Kunitada Shimotohno;Howard M. Temin

  • Construction of a helper cell line for avian reticuloendotheliosis virus cloning vectors

    S Watanabe;H M Temin

  • Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions.

    Vinay K. Pathak;Howard M. Temin

  • Structure, variation and synthesis of retrovirus long terminal repeat

    Howard M. Temin

  • An RNA-Dependent DNA Polymerase in Virions of Rous Sarcoma Virus

    Satoshi Mizutani;Howard M. Temin

Frequent Co-Authors

Michael Emerman
Michael Emerman Fred Hutchinson Cancer Research Center
John M. Coffin
John M. Coffin Tufts University
Kirk C. Wilhelmsen
Kirk C. Wilhelmsen University of North Carolina at Chapel Hill
Vinay K. Pathak
Vinay K. Pathak National Institutes of Health
Harold E. Varmus
Harold E. Varmus Cornell University
Kumao Toyoshima
Kumao Toyoshima Osaka University
Peter K. Vogt
Peter K. Vogt Scripps Research Institute
Sandra K. Weller
Sandra K. Weller University of Connecticut
Stephen Oroszlan
Stephen Oroszlan National Institutes of Health
Jay A. Levy
Jay A. Levy University of California, San Francisco

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