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Biology and Biochemistry

D-Index
74
Citations
15730
World Ranking
5739
National Ranking
2714

Overview

Sandra K. Weller is affiliated with the University of Connecticut in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a focus on epidemiology, molecular biology, infectious diseases, oncology, and public health. Their work covers a diverse range of topics, including herpesvirus infections and treatments, cytomegalovirus and herpesvirus research, SARS-CoV-2 and COVID-19 research, protein degradation and inhibitors, retinoids in leukemia and cellular processes, virus-based gene therapy research, and the biological effects of spaceflight.

Weller has contributed to several peer-reviewed publications. Notable recent papers include:

  • DNA Damage Kills Bacterial Spores and Cells Exposed to 222-Nanometer UV Radiation (2020), Applied and Environmental Microbiology
  • Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit (2021), The Journal of Infectious Diseases
  • The BCL-2 Selective Inhibitor ABT-199 Sensitizes Soft Tissue Sarcomas to Proteasome Inhibition by a Concerted Mechanism Requiring BAX and NOXA (2020), Cell Death and Disease
  • The Harms of Promoting the Lab Leak Hypothesis for SARS-CoV-2 Origins Without Evidence (2024), Journal of Virology
  • Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses (2022), mBio

The frequent coauthors collaborating with Weller include:

  • Hans-Georg Kopp
  • Frank Eßmann
  • Katherine A. DiScipio
  • Renata Szczepaniak
  • Dennis L. Wright

Their work has been published in several scientific venues, with repeated contributions to:

  • Cancer Research
  • Applied and Environmental Microbiology
  • The Journal of Infectious Diseases
  • Journal of Virology
  • Cell Death and Disease

Main fields of study include Medicine and Biochemistry, Genetics, and Molecular Biology, while subfields focus on epidemiology, molecular biology, infectious diseases, oncology, and public health-related areas.

Best Publications

  • Human blood IgM “memory” B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

    Sandra Weller;Moritz C. Braun;Bruce K. Tan;Andreas Rosenwald

  • CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

    Sandra Weller;Ahmad Faili;Corinne Garcia;Moritz C. Braun

  • Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant.

    D J Goldstein;S K Weller

  • Human Marginal Zone B Cells

    Jean-Claude Weill;Sandra Weller;Claude-Agnès Reynaud

  • The UL6 Gene Product Forms the Portal for Entry of DNA into the Herpes Simplex Virus Capsid

    William W. Newcomb;Rachel M. Juhas;Darrell R. Thomsen;Fred L. Homa

  • Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: characterization of an ICP6 deletion mutant.

    David J. Goldstein;Sandra K. Weller

  • Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products

    James J. Crute;Tatsuya Tsurumi;Liang Zhu;Sandra K. Weller

  • Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis.

    S K Weller;A Spadaro;J E Schaffer;A W Murray

  • Herpes Simplex Viruses: Mechanisms of DNA Replication

    Sandra K. Weller;Donald M. Coen

  • A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells.

    Jennie G. Jacobson;David A. Leib;David J. Goldstein;Connie L. Bogard

  • Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein.

    S K Weller;K J Lee;D J Sabourin;P A Schaffer

  • Recruitment of Cellular Recombination and Repair Proteins to Sites of Herpes Simplex Virus Type 1 DNA Replication Is Dependent on the Composition of Viral Proteins within Prereplicative Sites and Correlates with the Induction of the DNA Damage Response

    Dianna E. Wilkinson;Sandra K. Weller

  • Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+ B cell repertoire in infants

    Sandra Weller;Maria Mamani-Matsuda;Capucine Picard;Capucine Picard;Corinne Cordier

  • Correlation between cell killing and massive second-round superinfection by members of some subgroups of avian leukosis virus.

    S K Weller;A E Joy;H M Temin

  • Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain

    James S. Gibbs;Henry C. Chiou;Jennifer D. Hall;David W. Mount

  • Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.

    R Martinez;R T Sarisky;P C Weber;S K Weller

  • The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells.

    Maria Mamani-Matsuda;Antonio Cosma;Sandra Weller;Ahmad Faili

  • Proteasomal degradation restricts the nuclear lifespan of AID

    Said Aoufouchi;Ahmad Faili;Carole Zober;Orietta D'Orlando

  • An ICP6::lacZ insertional mutagen is used to demonstrate that the UL52 gene of herpes simplex virus type 1 is required for virus growth and DNA synthesis.

    D J Goldstein;S K Weller

  • The Herpes Simplex Virus Type 1 Cleavage/Packaging Protein, UL32, Is Involved in Efficient Localization of Capsids to Replication Compartments

    Carmela Lamberti;Sandra K. Weller

Frequent Co-Authors

Donald M. Coen
Donald M. Coen Harvard University
Priscilla A. Schaffer
Priscilla A. Schaffer Beth Israel Deaconess Medical Center
Capucine Picard
Capucine Picard Université Paris Cité
Jay C. Brown
Jay C. Brown University of Virginia
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
William W. Newcomb
William W. Newcomb National Institutes of Health
Howard M. Temin
Howard M. Temin University of Wisconsin–Madison
Christoph J. Binder
Christoph J. Binder Medical University of Vienna

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