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D-Index & Metrics

Microbiology

D-Index
58
Citations
10073
World Ranking
3480
National Ranking
1376

Overview

Jay C. Brown is affiliated with the University of Virginia in the United States and has conducted extensive research in the fields of biochemistry, genetics, and molecular biology. Their work spans multiple subfields, including molecular biology, genetics, infectious diseases, general health professions, and ecology.

The scientist's publications frequently appear in several venues, with the majority published in bioRxiv (Cold Spring Harbor Laboratory). Other frequent publication venues include the SSRN Electronic Journal, International Journal of Genomics, Heliyon, and the Journal of Public Health Issues and Practices. Jay C. Brown has collaborated with co-authors such as Floyd Huang, Ji' Lynda Brown, and Baomin Wang.

The main topics covered in their research include genomics and chromatin dynamics, RNA modifications and cancer, genetics and neurodevelopmental disorders, epigenetics and DNA methylation, cancer-related gene regulation, RNA research and splicing, as well as RNA and protein synthesis mechanisms.

  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer
  • Genetics and Neurodevelopmental Disorders
  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms

Some recent papers authored by Jay C. Brown include:

  • Role of Gene Length in Control of Human Gene Expression: Chromosome-Specific and Tissue-Specific Effects, 2021, International Journal of Genomics
  • Role of gene length in control of human gene expression: chromosome-specific and tissue-specific effects, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Involvement of promoter/enhancers in a feedback loop to regulate human gene expression, 2020, Heliyon
  • Role of polycomb repressive complex 2 in regulation of human transcription factor gene expression, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Role of Polycomb Repressive Complex 2 in Regulation of Human Transcription Factor Gene Expression, 2021, SSRN Electronic Journal

Their research contributes to a deeper understanding of gene expression regulation through studies on gene length, promoter/enhancer feedback loops, and the role of polycomb repressive complex 2 in transcription factor gene expression. The findings span chromosome-specific, tissue-specific, and epigenetic mechanisms.

Best Publications

  • Structures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstruction.

    T.S. Baker;W.W. Newcomb;N.H. Olson;L.M. Cowsert

  • The UL6 Gene Product Forms the Portal for Entry of DNA into the Herpes Simplex Virus Capsid

    William W. Newcomb;Rachel M. Juhas;Darrell R. Thomsen;Fred L. Homa

  • Liquid-crystalline, phage-like packing of encapsidated DNA in herpes simplex virus.

    F.P. Booy;W.W. Newcomb;B.L. Trus;J.C. Brown

  • Capsid assembly and DNA packaging in herpes simplex virus.

    Fred L. Homa;Jay C. Brown

  • Structure of the herpes simplex virus capsid : molecular composition of the pentons and the triplexes

    William W. Newcomb;Benes L. Trus;Frank P. Booy;Alasdair C. Steven

  • Assembly of the herpes simplex virus capsid: characterization of intermediates observed during cell-free capsid formation.

    William W. Newcomb;Fred L. Homa;Darrell R. Thomsen;Frank P. Booy

  • The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly.

    Benes L. Trus;Frank P. Booy;William W. Newcomb;Jay C. Brown

  • The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth.

    M Gao;L Matusick-Kumar;W Hurlburt;S F DiTusa

  • Mass and molecular composition of vesicular stomatitis virus: a scanning transmission electron microscopy analysis.

    D Thomas;W W Newcomb;J C Brown;J S Wall

  • The Product of the Herpes Simplex Virus Type 1 UL25 Gene Is Required for Encapsidation but Not for Cleavage of Replicated Viral DNA

    Alistair R. McNab;Prashant Desai;Stan Person;Lori L. Roof

  • Structure and Polymorphism of the UL6 Portal Protein of Herpes Simplex Virus Type 1

    Benes L. Trus;Naiqian Cheng;William W. Newcomb;Fred L. Homa

  • Herpesvirus capsid assembly: insights from structural analysis.

    Jay C Brown;William W Newcomb

  • Dynamics of herpes simplex virus capsid maturation visualized by time-lapse cryo-electron microscopy.

    J. Bernard Heymann;Naiqian Cheng;William W. Newcomb;Benes L. Trus;Benes L. Trus

  • Structure of the herpes simplex virus capsid: effects of extraction with guanidine hydrochloride and partial reconstitution of extracted capsids.

    W W Newcomb;J C Brown

  • Herpes Simplex Virus Replication: Roles of Viral Proteins and Nucleoporins in Capsid-Nucleus Attachment

    Anna Maria Copeland;William W. Newcomb;Jay C. Brown

  • Allosteric Signaling and a Nuclear Exit Strategy: Binding of UL25/UL17 Heterodimers to DNA-Filled HSV-1 Capsids

    Benes L. Trus;William W. Newcomb;Naiqian Cheng;Giovanni Cardone

  • Assembly of the Herpes Simplex Virus Procapsid from Purified Components and Identification of Small Complexes Containing the Major Capsid and Scaffolding Proteins

    William W. Newcomb;Fred L. Homa;Darrell R. Thomsen;Benes L. Trus

  • Herpes Simplex Virus DNA Cleavage and Packaging Proteins Associate with the Procapsid prior to Its Maturation

    Amy K. Sheaffer;William W. Newcomb;Min Gao;Dong Yu

  • Conserved Features in Papillomavirus and Polyomavirus Capsids

    David M. Belnap;Norman H. Olson;Norman H. Olson;Norman H. Olson;Nancy M. Cladel;Nancy M. Cladel;Nancy M. Cladel;William W. Newcomb;William W. Newcomb;William W. Newcomb

  • Initiator Codons in Eukaryotes

    J. C. Brown;A. E. Smith

  • Isolation of Herpes Simplex Virus Procapsids from Cells Infected with a Protease-Deficient Mutant Virus

    William W. Newcomb;Benes L. Trus;Naiqian Cheng;Alasdair C. Steven

Frequent Co-Authors

William W. Newcomb
William W. Newcomb National Institutes of Health
Benes L. Trus
Benes L. Trus National Institutes of Health
Alasdair C. Steven
Alasdair C. Steven National Institutes of Health
Naiqian Cheng
Naiqian Cheng National Institutes of Health
Timothy S. Baker
Timothy S. Baker University of California, San Diego
Sandra K. Weller
Sandra K. Weller University of Connecticut
James F. Conway
James F. Conway University of Pittsburgh
Neil D. Christensen
Neil D. Christensen Pennsylvania State University
Joseph S. Wall
Joseph S. Wall Brookhaven National Laboratory
Richard J. Colonno
Richard J. Colonno Bristol-Myers Squibb (Germany)

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