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Biology and Biochemistry

D-Index
65
Citations
11264
World Ranking
9408
National Ranking
4147

Overview

James F. Conway is affiliated with the University of Pittsburgh in the United States. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine. The primary areas of study focus on molecular biology, ecology, radiology, nuclear medicine, infectious diseases, and oncology.

The research topics that Conway has contributed to include:

  • Bacteriophages and microbial interactions
  • RNA interference and gene delivery
  • Plant virus research studies
  • HIV research and treatment
  • Monoclonal and polyclonal antibodies research
  • RNA and protein synthesis mechanisms
  • Bacterial genetics and biotechnology

Conway has published in various scientific journals, with frequent publication venues being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Science Advances
  • Nucleic Acids Research

James F. Conway's recent papers include:

  • "Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy," 2024, Nature Communications
  • "Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy," 2022, Nature Nanotechnology
  • "Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes," 2021, Nature Communications
  • "The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function," 2021, Scientific Reports
  • "Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1," 2020, Journal of Molecular Biology

Frequent co-authors with whom Conway has collaborated include:

  • Alexis Huet
  • Robert L. Duda
  • Herman K.H. Fung
  • Alfred A. Antson
  • Yuang Chen

Best Publications

  • Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy

    J F Conway;N Cheng;A Zlotnick;P T Wingfield

  • Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

    Ashwani K Thakur;Murali Jayaraman;Rakesh Mishra;Monika Thakur

  • Dimorphism of Hepatitis B Virus Capsids Is Strongly Influenced by the C-Terminus of the Capsid Protein

    A Zlotnick;N Cheng;J F Conway;F P Booy

  • Molecular Tectonic Model of Virus Structural Transitions: the Putative Cell Entry States of Poliovirus

    David M. Belnap;David J. Filman;Benes L. Trus;Naiqian Cheng

  • Intermediate filament structure: 3. Analysis of sequence homologies

    James F. Conway;David A.D. Parry

  • Localization of the C Terminus of the Assembly Domain of Hepatitis B Virus Capsid Protein: Implications for Morphogenesis and Organization of Encapsidated RNA

    A. Zlotnick;N. Cheng;S. J. Stahl;J. F. Conway

  • Novel fold and capsid-binding properties of the lambda-phage display platform protein gpD.

    Fan Yang;Patrik Forrer;Zbigniew Dauter;James F. Conway

  • Virus maturation involving large subunit rotations and local refolding.

    J. F. Conway;W. R. Wikoff;N. Cheng;R. L. Duda

  • Structural features in the heptad substructure and longer range repeats of two-stranded α-fibrous proteins

    James F. Conway;David A.D. Parry

  • Virus maturation: dynamics and mechanism of a stabilizing structural transition that leads to infectivity

    Alasdair C Steven;J Bernard Heymann;Naiqian Cheng;Benes L Trus

  • Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale

    Ping An Fang;James F. Conway;Henry C. Margolis;James P. Simmer

  • Proteolytic and Conformational Control of Virus Capsid Maturation: The Bacteriophage HK97 System

    J.F. Conway;R.L. Duda;N. Cheng;R.W. Hendrix

  • Genomic and structural analysis of Syn9, a cyanophage infecting marine Prochlorococcus and Synechococcus.

    Peter R. Weigele;Welkin H. Pope;Marisa L. Pedulla;Jennifer M. Houtz

  • Methods for reconstructing density maps of "single" particles from cryoelectron micrographs to subnanometer resolution.

    James F. Conway;Alasdair C. Steven

  • Maturation Dynamics of a Viral Capsid: Visualization of Transitional Intermediate States

    Ramani Lata;James F Conway;Naiqian Cheng;Robert L Duda

  • The cellular receptor to human rhinovirus 2 binds around the 5-fold axis and not in the canyon: a structural view

    Elizabeth A. Hewat;Emmanuelle Neumann;James F. Conway;Rosita Moser

  • An Estimate of the Mean Length of Collagen Fibrils in Rat Tail-Tendon as a Function of age

    Alan S. Craig;Mervyn J. Birtles;James F. Conway;David A.D. Parry

  • A quasi‐atomic model of human adenovirus type 5 capsid

    Céline M S Fabry;Manuel Rosa-Calatrava;James F Conway;Chloé Zubieta

  • The Enterovirus 71 A-particle Forms a Gateway to Allow Genome Release: A CryoEM Study of Picornavirus Uncoating

    Kristin L. Shingler;Jennifer L. Yoder;Michael S. Carnegie;Robert E. Ashley

  • Finding a needle in a haystack: detection of a small protein (the 12-kDa VP26) in a large complex (the 200-MDa capsid of herpes simplex virus).

    F P Booy;B L Trus;W W Newcomb;J C Brown

Frequent Co-Authors

Naiqian Cheng
Naiqian Cheng National Institutes of Health
Alasdair C. Steven
Alasdair C. Steven National Institutes of Health
Roger W. Hendrix
Roger W. Hendrix University of Pittsburgh
Paul T. Wingfield
Paul T. Wingfield National Institutes of Health
Benes L. Trus
Benes L. Trus National Institutes of Health
Stephen J. Stahl
Stephen J. Stahl National Institutes of Health
John E. Johnson
John E. Johnson Scripps Research Institute
Adam Zlotnick
Adam Zlotnick Indiana University
Guy Schoehn
Guy Schoehn Grenoble Alpes University
David A.D. Parry
David A.D. Parry Massey University

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