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Biology and Biochemistry

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67
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14565
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Overview

Michael Nassal is affiliated with the University of Freiburg in Germany and has a research focus centered on medicine, particularly within the fields of epidemiology, hepatology, and infectious diseases. Their work encompasses molecular biology aspects related to viral infections, with a specialization in Hepatitis B Virus (HBV) and related virological studies.

The scientist's main topics of research include:

  • Hepatitis B Virus Studies
  • Hepatitis C virus research
  • Bacteriophages and microbial interactions
  • Advanced NMR Techniques and Applications
  • NMR spectroscopy and applications
  • Viral gastroenteritis research and epidemiology
  • Viral Infections and Outbreaks Research

Recent papers authored or co-authored by Michael Nassal cover a range of subjects relevant to viral structure and antiviral strategies. Notable recent publications include:

  • "Biomolecular solid-state NMR spectroscopy at 1200 MHz: the gain in resolution" (2021), Journal of Biomolecular NMR
  • "Nomenclature of HBV core protein-targeting antivirals" (2022), Nature Reviews Gastroenterology & Hepatology
  • "The Hepatitis B Virus Nucleocapsid-Dynamic Compartment for Infectious Virus Production and New Antiviral Target" (2021), Biomedicines
  • "Hepatitis B virus-host interactions and novel targets for viral cure" (2021), Current Opinion in Virology
  • "Solid-State NMR for Studying the Structure and Dynamics of Viral Assemblies" (2020), Viruses

Michael Nassal frequently collaborates with several researchers in the field, including:

  • Lauriane Lecoq
  • Anja Böckmann
  • Marie-Laure Fogeron
  • Beat H. Meier
  • Alexander A. Malär

The scientist has published multiple articles in prominent venues such as:

  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Microbiology Spectrum
  • Gut
  • bioRxiv (Cold Spring Harbor Laboratory)

Michael Nassal's research integrates virology with advanced nuclear magnetic resonance (NMR) methodologies, contributing to the understanding of viral assembly and antiviral targets. Their work has significance in both fundamental virology and the development of therapeutic strategies, with an emphasis on hepatitis viruses.

Best Publications

  • HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

    Michael Nassal

  • Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

    Yi Ni;Florian A. Lempp;Stefan Mehrle;Shirin Nkongolo

  • Hepatitis B virus replication.

    Juergen Beck;Michael Nassal

  • The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly

    M Nassal

  • Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein.

    F Birnbaum;M Nassal

  • Hepatitis B viruses: reverse transcription a different way.

    Michael Nassal

  • Native display of complete foreign protein domains on the surface of hepatitis B virus capsids.

    Peter A. Kratz;Bettina Böttcher;Michael Nassal

  • Total synthesis of a gene for bovine rhodopsin

    L. Ferretti;Sadashiva S Karnik;H. G. Khorana;M. Nassal

  • Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses.

    Christian Königer;Ida Wingert;Moritz Marsmann;Christine Rösler

  • CORE PARTICLES OF HEPATITIS B VIRUS AS CARRIER FOR FOREIGN EPITOPES

    Rainer Ulrich;Michael Nassal;Helga Meisel;Detlev H. Krüger

  • Hepatitis B virus replication.

    Michael Nassal;Heinz Schaller

  • Hepatitis B virus replication--an update.

    M. Nassal;H. Schaller

  • Efficient Infection of Primary Tupaia Hepatocytes with Purified Human and Woolly Monkey Hepatitis B Virus

    Josef Köck;Michael Nassal;Sabine MacNelly;Thomas F. Baumert

  • A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesis.

    M Nassal;A Rieger

  • Translational inactivation of RNA function : discrimination against a subset of genomic transcripts during HBV nucleocapsid assembly

    Michael Nassal;Michael Junker-Niepmann;Heinz Schaller

  • A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.

    Eloi R. Verrier;Che C. Colpitts;Charlotte Bach;Laura Heydmann

  • Evolutionary conservation in the hepatitis B virus core structure: comparison of human and duck cores.

    John M Kenney;Carl-Henrik von Bonsdorff;Michael Nassal;Stephen D Fuller

  • Hepatitis B and C virus coinfection: A novel model system reveals the absence of direct viral interference

    Pantxika Bellecave;Jérôme Gouttenoire;Markus Gajer;Volker Brass

  • The encapsidation signal on the hepatitis B virus RNA pregenome forms a stem-loop structure that is critical for its function.

    Thomas Knaus;Michael Nassal

  • Hepatitis B Virus Morphogenesis

    M. Nassal

Frequent Co-Authors

Hubert E. Blum
Hubert E. Blum University of Freiburg
Anja Böckmann
Anja Böckmann University of Lyon System
Beat H. Meier
Beat H. Meier ETH Zurich
Thomas F. Baumert
Thomas F. Baumert University of Strasbourg
Heinz Schaller
Heinz Schaller Heidelberg University
Ralf Bartenschlager
Ralf Bartenschlager Heidelberg University
Patrice André
Patrice André Claude Bernard University Lyon 1
Ulrike Protzer
Ulrike Protzer Technical University of Munich
Stephan Urban
Stephan Urban University Hospital Heidelberg
Reinhard Wallich
Reinhard Wallich Heidelberg University

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