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Biology and Biochemistry

D-Index
61
Citations
15330
World Ranking
11240
National Ranking
4866

Overview

Rafael Moreno-Sánchez is affiliated with the University of Colorado Denver in the United States. Their research focuses on areas within biochemistry, genetics, molecular biology, and medicine, with particular emphasis on cancer research and molecular biology subfields. Their work spans topics such as cancer, hypoxia, and metabolism; diet and metabolism studies; mitochondrial function and pathology; metabolism, diabetes, and cancer; microbial metabolic engineering and bioproduction; inflammatory mediators and NSAID effects; and estrogen and related hormone effects.

The scientist has contributed to multiple publications in several specialized venues. Frequent publication venues include Frontiers in Oncology, Algal Research, Archives of Biochemistry and Biophysics, Biochimica et Biophysica Acta (BBA) - General Subjects, and Mini-Reviews in Medicinal Chemistry.

Notable recent papers authored or co-authored by Rafael Moreno-Sánchez include:

  • Non-Steroidal Anti-Inflammatory Drugs Increase Cisplatin, Paclitaxel, and Doxorubicin Efficacy against Human Cervix Cancer Cells (2020, Pharmaceuticals)
  • Physiological Role of Glutamate Dehydrogenase in Cancer Cells (2020, Frontiers in Oncology)
  • Acetate Promotes a Differential Energy Metabolic Response in Human HCT 116 and COLO 205 Colon Cancer Cells Impacting Cancer Cell Growth and Invasiveness (2021, Frontiers in Oncology)
  • Kinetic modeling of glucose central metabolism in hepatocytes and hepatoma cells (2020, Biochimica et Biophysica Acta (BBA) - General Subjects)
  • Protein acetylation effects on enzyme activity and metabolic pathway fluxes (2021, Journal of Cellular Biochemistry)

Collaborations play a significant role in Moreno-Sánchez's research, with frequent co-authors including Sara Rodríguez-Enríquez, Diana Xochiquetzal Robledo-Cadena, Silvia Cecilia Pacheco-Velázquez, Emma Saavedra, and Álvaro Marín-Hernández.

The scientist's work integrates biochemical and molecular approaches to investigate cancer cell metabolism and responses, metabolic pathway fluxes, and the influence of various compounds such as non-steroidal anti-inflammatory drugs on cancer treatment efficacy. Their contributions include kinetic modeling and exploration of enzyme activity regulation.

These research efforts provide insights into cellular metabolic mechanisms related to cancer progression and treatment, contributing to broader fields of oncology, physiology, and biochemical research.

Best Publications

  • Interactions of chromium with microorganisms and plants

    Carlos Cervantes;Jesús Campos-García;Silvia Devars;Félix Gutiérrez-Corona

  • Energy metabolism in tumor cells

    Rafael Moreno-Sánchez;Sara Rodríguez-Enríquez;Alvaro Marín-Hernández;Emma Saavedra

  • HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

    Alvaro Marin-Hernandez;Juan C. Gallardo-Perez;Stephen John Ralph;Sara Rodriguez-Enriquez

  • Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants.

    David Mendoza-Cózatl;Herminia Loza-Tavera;Andrea Hernández-Navarro;Rafael Moreno-Sánchez

  • The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy.

    Stephen John Ralph;Sara Rodríguez-Enríquez;Jiri Neuzil;Jiri Neuzil;Emma Saavedra

  • Mitochondrial Bound Hexokinase Activity as a Preventive Antioxidant Defense STEADY-STATE ADP FORMATION AS A REGULATORY MECHANISM OF MEMBRANE POTENTIAL AND REACTIVE OXYGEN SPECIES GENERATION IN MITOCHONDRIA

    Wagner Seixas da-Silva;Armando Gómez-Puyou;Marietta Tuena de Gómez-Puyou;Rafael Moreno-Sanchez

  • Heart metabolic disturbances in cardiovascular diseases.

    Karla Carvajal;Rafael Moreno-Sánchez

  • Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II

    Lan-feng Dong;Victoria J. A. Jameson;David Patrice Tilly;Jiri Cerny

  • Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase.

    Alvaro Marín-Hernández;Sara Rodríguez-Enríquez;Paola A. Vital-González;Fanny L. Flores-Rodríguez

  • Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.

    Rafael Moreno-Sánchez;Emma Saavedra;Sara Rodríguez-Enríquez;Viridiana Olín-Sandoval

  • Chromate Efflux by Means of the ChrA Chromate Resistance Protein from Pseudomonas aeruginosa

    Angel H. Alvarez;Rafael Moreno-Sánchez;Carlos Cervantes

  • Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism.

    Rafael Moreno-Sánchez;Alvaro Marín-Hernández;Emma Saavedra;Juan P. Pardo

  • Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

    Stephen John Ralph;Sara Rodríguez-Enríquez;Jiri Neuzil;Jiri Neuzil;Rafael Moreno-Sánchez

  • Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart.

    Rafael Moreno-Sánchez;Concepción Bravo;César Vásquez;Guadalupe Ayala

  • HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression

    Beatrice Philip;Koichi Ito;Rafael Moreno-Sánchez;Stephen John Ralph

  • Multisite control of the Crabtree effect in ascites hepatoma cells

    Sara Rodríguez-Enríquez;Oscar Juárez;José S. Rodríguez-Zavala;Rafael Moreno-Sánchez

  • Energy metabolism transition in multi‐cellular human tumor spheroids

    Sara Rodríguez-Enríquez;Juan Carlos Gallardo-Pérez;Alejandro Avilés-Salas;Alvaro Marín-Hernández

  • Control of glutathione and phytochelatin synthesis under cadmium stress. Pathway modeling for plants.

    David G. Mendoza-Cózatl;Rafael Moreno-Sánchez

  • Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

    Stephen John Ralph;Rafael Moreno-Sánchez;Jiri Neuzil;Jiri Neuzil;Sara Rodríguez-Enríquez

  • Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration.

    R Moreno-Sánchez;R G Hansford

Frequent Co-Authors

Stephen John Ralph
Stephen John Ralph Griffith University
David G. Mendoza-Cózatl
David G. Mendoza-Cózatl University of Missouri
Jiri Neuzil
Jiri Neuzil Czech Academy of Sciences
Richard G. Hansford
Richard G. Hansford National Institutes of Health
Hans V. Westerhoff
Hans V. Westerhoff Vrije Universiteit Amsterdam
Paul A. M. Michels
Paul A. M. Michels University of Edinburgh
Jacky L. Snoep
Jacky L. Snoep Stellenbosch University
Hagai Rottenberg
Hagai Rottenberg Drexel University
Paul K. Witting
Paul K. Witting University of Sydney
Rudi Balling
Rudi Balling University of Bonn

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