His primary areas of investigation include Mitochondrial DNA, Mitochondrion, Molecular biology, Genetics and DNA replication. Howard T. Jacobs combines subjects such as Mutation, Point mutation and DNA with his study of Mitochondrial DNA. His Mitochondrion research includes elements of Oxidative phosphorylation and Genome.
His Molecular biology research incorporates elements of TFAM and DNA polymerase II. Howard T. Jacobs interconnects Hypoxia-inducible factors, Ciona intestinalis, Cytochrome c oxidase and Mitochondrial ROS in the investigation of issues within Alternative oxidase. His work carried out in the field of Respiratory chain brings together such families of science as Oxidative stress, Reactive oxygen species and ATP synthase.
Howard T. Jacobs mainly investigates Genetics, Mitochondrial DNA, Mitochondrion, Molecular biology and Cell biology. His Gene, Mutant, Mutation, Mitochondrial disease and Phenotype investigations are all subjects of Genetics research. Howard T. Jacobs has included themes like Point mutation, Genome and DNA, DNA replication in his Mitochondrial DNA study.
His Mitochondrion research is multidisciplinary, incorporating elements of Oxidative phosphorylation and Transfer RNA. Howard T. Jacobs has researched Molecular biology in several fields, including Heteroplasmy, RNA, Promoter, DNA polymerase II and Transcription. His work deals with themes such as Drosophila melanogaster and Gene knockdown, which intersect with Cell biology.
Howard T. Jacobs mainly focuses on Cell biology, Alternative oxidase, Mitochondrion, Respiratory chain and Mitochondrial DNA. His biological study spans a wide range of topics, including RNA, Mutant, Gene knockdown and Mitochondrial disease. His Alternative oxidase research is classified as research in Biochemistry.
His Mitochondrion research includes themes of Golgi apparatus, Oxidative phosphorylation, Endocytosis and Metabolism. The various areas that Howard T. Jacobs examines in his Respiratory chain study include Respiratory enzyme, Transgene, Drosophila melanogaster, Ciona intestinalis and ATP synthase. His research in Mitochondrial DNA intersects with topics in DNA and Genotype.
His main research concerns Cell biology, Mitochondrion, Alternative oxidase, Respiratory chain and Mitochondrial DNA. His research integrates issues of Polyadenylation and Transfer RNA in his study of Cell biology. The concepts of his Mitochondrion study are interwoven with issues in RNA, Translation, Messenger RNA and Protein biosynthesis.
His Alternative oxidase study combines topics in areas such as Autophagy, Mitochondrial myopathy, Mitochondrial disease and Myopathy. His study in Respiratory chain is interdisciplinary in nature, drawing from both Reactive oxygen species, Cardiomyopathy and Transgene. Mitochondrial DNA is a subfield of Gene that he investigates.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Aleksandra Trifunovic;Anna Wredenberg;Maria Falkenberg;Johannes N. Spelbrink.
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Evanna L. Mills;Beth Kelly;Angela Logan;Ana S.H. Costa.
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.
Johannes N. Spelbrink;Fang Yuan Li;Valeria Tiranti;Kaisu Nikali.
Nature Genetics (2001)
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
Aleksandra Trifunovic;Anna Hansson;Anna Wredenberg;Anja T. Rovio.
Proceedings of the National Academy of Sciences of the United States of America (2005)
Coupled Leading- and Lagging-Strand Synthesis of Mammalian Mitochondrial DNA
Ian J Holt;Heather E Lorimer;Howard T Jacobs;Howard T Jacobs.
Nucleotide sequence and gene organization of sea urchin mitochondrial DNA.
Howard T. Jacobs;David J. Elliott;Veerabhadracharya B. Math;Andrew Farquharson.
Journal of Molecular Biology (1990)
A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness
Fiona M. Reid;Guy A. Vernham;Howard T. Jacobs.
Human Mutation (1994)
Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.
Ming Yao Yang;Mark Bowmaker;Aurelio Reyes;Lodovica Vergani.
Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.
Takehiro Yasukawa;Aurelio Reyes;Tricia J. Cluett;Ming Yao Yang.
The EMBO Journal (2006)
Mammalian Mitochondrial DNA Replicates Bidirectionally from an Initiation Zone
Mark Bowmaker;Ming Yao Yang;Takehiro Yasukawa;Aurelio Reyes.
Journal of Biological Chemistry (2003)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: