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Howard T. Jacobs

Howard T. Jacobs

D-Index & Metrics

Genetics

D-Index
65
Citations
20159
World Ranking
2672
National Ranking
19

Overview

Howard T. Jacobs is affiliated with Tampere University in Finland. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a substantial number of publications in the broader field totaling 55. Jacobs's work spans several subfields including molecular biology, ecology, physiology, genetics, and cellular and molecular neuroscience.

The main topics explored in Jacobs's research include mitochondrial function and pathology, adipose tissue and metabolism, metabolomics and mass spectrometry studies, ATP synthase and ATPases research, neurobiology and insect physiology research, physiological and biochemical adaptations, and parasite biology and host interactions.

Jacobs has a record of frequent collaboration with other researchers. The most common coauthors include Éric Dufour, Marten Szibor, Paule Bénit, Pierre Rustin, and Mü­gen Terzioglu.

Publication venues where Jacobs regularly contributes include EMBO Reports, bioRxiv (Cold Spring Harbor Laboratory), Fly, Biochimica et Biophysica Acta (BBA) - Bioenergetics, and The Journal of Biochemistry.

Recent significant papers authored or coauthored by Jacobs cover various aspects of mitochondrial biology and related biochemical processes. These papers include:

  • Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism (2020, The Journal of Biochemistry)
  • What physiological role(s) does the alternative oxidase perform in animals? (2022, Biochimica et Biophysica Acta (BBA) - Bioenergetics)
  • Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation (2022, Nature Immunology)
  • Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing (2020, Science Advances)
  • Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia (2020, Journal of Cellular and Molecular Medicine)

Best Publications

  • Premature ageing in mice expressing defective mitochondrial DNA polymerase

    Aleksandra Trifunovic;Anna Wredenberg;Maria Falkenberg;Johannes N. Spelbrink

  • Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

    Evanna L. Mills;Beth Kelly;Angela Logan;Ana S.H. Costa

  • Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.

    Johannes N. Spelbrink;Fang Yuan Li;Valeria Tiranti;Kaisu Nikali

  • Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

    Aleksandra Trifunovic;Anna Hansson;Anna Wredenberg;Anja T. Rovio

  • Coupled Leading- and Lagging-Strand Synthesis of Mammalian Mitochondrial DNA

    Ian J Holt;Heather E Lorimer;Howard T Jacobs;Howard T Jacobs

  • Mitochondria are physiologically maintained at close to 50 °C.

    Dominique Chretien;Paule Benit;Paule Benit;Hyung-Ho Ha;Susanne Keipert

  • Nucleotide sequence and gene organization of sea urchin mitochondrial DNA.

    Howard T. Jacobs;David J. Elliott;Veerabhadracharya B. Math;Andrew Farquharson

  • A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness

    Fiona M. Reid;Guy A. Vernham;Howard T. Jacobs

  • Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.

    Ming Yao Yang;Mark Bowmaker;Aurelio Reyes;Lodovica Vergani

  • Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.

    Takehiro Yasukawa;Aurelio Reyes;Tricia J. Cluett;Ming Yao Yang

  • Mammalian Mitochondrial DNA Replicates Bidirectionally from an Initiation Zone

    Mark Bowmaker;Ming Yao Yang;Takehiro Yasukawa;Aurelio Reyes

  • Mitochondrial medicine: a metabolic perspective on the pathology of oxidative phosphorylation disorders.

    Jan A. Smeitink;Massimo Zeviani;Douglass M. Turnbull;Howard T. Jacobs;Howard T. Jacobs

  • Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes

    D R Dunbar;P A Moonie;H T Jacobs;I J Holt

  • Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter.

    Anna Rubio-Cosials;Jasmin F Sidow;Jasmin F Sidow;Nereida Jiménez-Menéndez;Pablo Fernández-Millán

  • Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility

    Anja T. Rovio;David R. Marchington;Susanne Donat;Hans Christian Schuppe

  • In Vivo Functional Analysis of the Human Mitochondrial DNA Polymerase POLG Expressed in Cultured Human Cells

    Johannes N. Spelbrink;Janne M. Toivonen;Gerrit A.J. Hakkaart;Johanna M. Kurkela

  • A Bidirectional Origin of Replication Maps to the Major Noncoding Region of Human Mitochondrial DNA

    Takehiro Yasukawa;Ming Yao Yang;Howard T. Jacobs;Howard T. Jacobs;Ian J. Holt

  • Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

    Yee Liu Chua;Eric Dufour;Emmanuel P. Dassa;Pierre Rustin

  • Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

    Jaakko L. O. Pohjoismäki;Sjoerd Wanrooij;Anne K. Hyvärinen;Steffi Goffart

  • Expression of the Ciona intestinalis Alternative Oxidase (AOX) in Drosophila Complements Defects in Mitochondrial Oxidative Phosphorylation

    Daniel J.M. Fernandez-Ayala;Alberto Sanz;Suvi Vartiainen;Kia K. Kemppainen

Frequent Co-Authors

Ian J. Holt
Ian J. Holt Medical Research Council
Johannes N. Spelbrink
Johannes N. Spelbrink Radboud University
Laurie S. Kaguni
Laurie S. Kaguni Michigan State University
Thomas Braun
Thomas Braun Max Planck Society
Massimo Zeviani
Massimo Zeviani University of Padua
Paule Bénit
Paule Bénit Grenoble Alpes University
Mingyao Yang
Mingyao Yang Sichuan Agricultural University
Joanna Poulton
Joanna Poulton University of Oxford
Jack D. Griffith
Jack D. Griffith University of North Carolina at Chapel Hill

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