World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
71
Citations
17758
World Ranking
1378
National Ranking
104

Overview

Ian J. Holt is affiliated with the Medical Research Council in the United Kingdom. Their research primarily focuses on Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine. Within these fields, they have specialized in several subfields including Molecular Biology, Neurology, Clinical Biochemistry, Genetics, and Cardiology and Cardiovascular Medicine.

The scientist's work has covered a variety of topics including:

  • Mitochondrial Function and Pathology
  • RNA Research and Splicing
  • Metabolism and Genetic Disorders
  • ATP Synthase and ATPases Research
  • Nuclear Structure and Function
  • Amyotrophic Lateral Sclerosis Research
  • RNA modifications and cancer

Recent papers reflect the range of their research interests. Significant publications include:

  • "Recurrent De Novo NAHR Reciprocal Duplications in the ATAD3 Gene Cluster Cause a Neurogenetic Trait with Perturbed Cholesterol and Mitochondrial Metabolism," published in 2020 in The American Journal of Human Genetics
  • "2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA," published in 2021 in Nature Communications
  • "Defects of Nutrient Signaling and Autophagy in Neurodegeneration," published in 2022 in Frontiers in Cell and Developmental Biology
  • "Muscle cell differentiation and development pathway defects in Emery-Dreifuss muscular dystrophy," published in 2020 in Neuromuscular Disorders
  • "2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart," published in 2022 in Scientific Reports

Their frequent co-authors include:

  • Antonella Spinazzola
  • Uxoa Fernández-Pelayo
  • Heidi R. Fuller
  • Mikel Muñoz-Oreja
  • Adolfo López de Munaín

The most common venues for publications by this scientist are:

  • Neuromuscular Disorders
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The American Journal of Human Genetics
  • Nature Communications
  • Frontiers in Cell and Developmental Biology

Best Publications

  • Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

    I. J. Holt;A. E. Harding;J. A. Morgan-Hughes

  • A new mitochondrial disease associated with mitochondrial DNA heteroplasmy

    I. J. Holt;A. E. Harding;R. K. H. Petty;J. A. Morgan-Hughes

  • Coupled Leading- and Lagging-Strand Synthesis of Mammalian Mitochondrial DNA

    Ian J Holt;Heather E Lorimer;Howard T Jacobs;Howard T Jacobs

  • Enzymatic removal of ribonucleotides from DNA is essential for Mammalian genome integrity and development

    Martin A.M. Reijns;Björn Rabe;Rachel E. Rigby;Pleasantine Mill

  • Minimizing the damage: repair pathways keep mitochondrial DNA intact

    Lawrence Kazak;Aurelio Reyes;Ian J. Holt

  • Blue Native electrophoresis to study mitochondrial and other protein complexes.

    Leo G J Nijtmans;Nadine S Henderson;Ian J Holt

  • PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

    Sara García-Gómez;Aurelio Reyes;María I. Martínez-Jiménez;E. Sandra Chocrón

  • Mitochondrial myopathies: Clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA

    I. J. Holt;A. E. Harding;J. M. Cooper;J. M. Cooper;A. H. V. Schapira

  • Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.

    Ming Yao Yang;Mark Bowmaker;Aurelio Reyes;Lodovica Vergani

  • Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.

    Takehiro Yasukawa;Aurelio Reyes;Tricia J. Cluett;Ming Yao Yang

  • Pearson syndrome and mitochondrial encephalomyopathy in a patient with a deletion of mtDNA.

    M A McShane;S R Hammans;M Sweeney;I J Holt

  • Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number

    Henna Tyynismaa;Hiroshi Sembongi;Monika Bokori-Brown;Caroline Granycome

  • Mammalian Mitochondrial DNA Replicates Bidirectionally from an Initiation Zone

    Mark Bowmaker;Ming Yao Yang;Takehiro Yasukawa;Aurelio Reyes

  • The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization

    Jiuya He;Chih-Chieh Mao;Aurelio Reyes;Hiroshi Sembongi

  • Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication

    Javier Miralles Fusté;Sjoerd Wanrooij;Elisabeth Jemt;Caroline E. Granycome

  • Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes

    D R Dunbar;P A Moonie;H T Jacobs;I J Holt

  • Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis

    J. He;H. M. Cooper;A. Reyes;M. Di Re

  • A Bidirectional Origin of Replication Maps to the Major Noncoding Region of Human Mitochondrial DNA

    Takehiro Yasukawa;Ming Yao Yang;Howard T. Jacobs;Howard T. Jacobs;Ian J. Holt

  • Human Mitochondrial DNA Replication

    Ian J. Holt;Aurelio Reyes

  • TEFM (c17orf42) is necessary for transcription of human mtDNA

    Michal Minczuk;Jiuya He;Anna M. Duch;Thijs J. Ettema

Frequent Co-Authors

Howard T. Jacobs
Howard T. Jacobs Tampere University
Johannes N. Spelbrink
Johannes N. Spelbrink Radboud University
Joanna Poulton
Joanna Poulton University of Oxford
Mingyao Yang
Mingyao Yang Sichuan Agricultural University
Kimitsuna Watanabe
Kimitsuna Watanabe National Institute of Advanced Industrial Science and Technology
Robert J. Crouch
Robert J. Crouch National Institutes of Health
Michal Minczuk
Michal Minczuk University of Cambridge
John E. Walker
John E. Walker University of Cambridge
Ian M. Fearnley
Ian M. Fearnley University of Cambridge
Tsutomu Suzuki
Tsutomu Suzuki University of Tokyo

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