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Molecular Biology

D-Index
48
Citations
10215
World Ranking
2675
National Ranking
1303

Overview

Robert J. Crouch is a researcher affiliated with the National Institutes of Health in the United States. Their work focuses primarily within the broader discipline of Biochemistry, Genetics, and Molecular Biology, with significant contributions to the subfields of Molecular Biology, Immunology, and Cell Biology.

The main topics explored in their research include:

  • DNA Repair Mechanisms
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • RNA Research and Splicing
  • DNA and Nucleic Acid Chemistry
  • Genomics and Chromatin Dynamics
  • Toxin Mechanisms and Immunotoxins

The researcher has published multiple papers across several scientific journals. Some recent publications include:

  • "RNA abasic sites in yeast and human cells," 2020, Proceedings of the National Academy of Sciences
  • "R-Loop Analysis by Dot-Blot," 2021, Journal of Visualized Experiments
  • "RNase H1, the Gold Standard for R-Loop Detection," 2022, Methods in molecular biology
  • "A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE," 2022, Nucleic Acids Research
  • "High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase," 2020, Nucleic Acids Research

The venues where these papers have appeared also reflect the scope of their work and include:

  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Journal of Visualized Experiments
  • Methods in molecular biology

Frequent collaborators in their research include:

  • Vivian G. Cheung
  • Yaojuan Liu
  • Yesenia Rodriguez
  • Jason A. Watts
  • Christopher Grunseich

Best Publications

  • Ribonuclease H: the enzymes in Eukaryotes

    Susana M. Cerritelli;Robert J. Crouch

  • Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis

    Marcin Nowotny;Sergei A. Gaidamakov;Robert J. Crouch;Wei Yang

  • Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein.

    Wei Yang;Wayne A. Hendrickson;Robert J. Crouch;Yoshinori Satow

  • Sorting of mannose 6-phosphate receptors mediated by the GGAs.

    Rosa Puertollano;Rubén C. Aguilar;Inna Gorshkova;Robert J. Crouch

  • Failure to Produce Mitochondrial DNA Results in Embryonic Lethality in Rnaseh1 Null Mice

    Susana M. Cerritelli;Ella G. Frolova;Chiguang Feng;Alexander Grinberg

  • RNase H2-Initiated Ribonucleotide Excision Repair

    Justin L. Sparks;Hyongi Chon;Susana M. Cerritelli;Thomas A. Kunkel

  • Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription

    Marcin Nowotny;Sergei A. Gaidamakov;Rodolfo Ghirlando;Susana M. Cerritelli

  • Degradation of DNA RNA Hybrids by Ribonuclease H and DNA Polymerases of Cellular and Viral Origin

    Walter Keller;Robert Crouch

  • Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

    Scott R. Budihas;Inna Gorshkova;Sergei Gaidamakov;Antony Wamiru

  • Identification of the genes encoding Mn2+-dependent RNase HII and Mg2+-dependent RNase HIII from Bacillus subtilis: classification of RNases H into three families.

    Naoto Ohtani;Mitsuru Haruki;Masaaki Morikawa;Robert J. Crouch

  • RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

    Vladislav Pokatayev;Naushaba Hasin;Hyongi Chon;Susana M. Cerritelli

  • RNase H2 roles in genome integrity revealed by unlinking its activities

    Hyongi Chon;Justin L. Sparks;Monika Rychlik;Marcin Nowotny

  • The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair.

    Arulvathani Arudchandran;Susana Cerritelli;Scott Narimatsu;Mitsuhiro Itaya

  • Signal-binding Specificity of the μ4 Subunit of the Adaptor Protein Complex AP-4 *

    Ruben C. Aguilar;Markus Boehm;Inna Gorshkova;Robert J. Crouch

  • Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex

    Hyongi Chon;Alex Vassilev;Melvin L. DePamphilis;Yingming Zhao

  • Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid

    Jaakko L.O. Pohjoismäki;J. Bradley Holmes;J. Bradley Holmes;Stuart R. Wood;Ming Yao Yang

  • Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.

    Marcin Nowotny;Susana M Cerritelli;Rodolfo Ghirlando;Sergei A Gaidamakov

  • RNase H2 of Saccharomyces cerevisiae is a complex of three proteins

    Ho‐Sang Jeong;Peter S. Backlund;Hao‐Chia Chen;Alexander A. Karavanov

  • Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage.

    Monika P. Rychlik;Hyongi Chon;Susana M. Cerritelli;Paulina Klimek

  • Ribonuclease III Does Not Degrade Deoxyribonucleic Acid-Ribonucleic Acid Hybrids

    Robert J. Crouch

Frequent Co-Authors

Ian J. Holt
Ian J. Holt Medical Research Council
Shigenori Kanaya
Shigenori Kanaya Osaka University
Herbert C. Morse
Herbert C. Morse National Institute of Allergy and Infectious Diseases
Howard T. Jacobs
Howard T. Jacobs Tampere University
Ryan J. Taft
Ryan J. Taft Illumina (United States)
Peter M. J. Burgers
Peter M. J. Burgers Washington University in St. Louis
Jacob V. Maizel
Jacob V. Maizel National Institutes of Health
Judith G. Levin
Judith G. Levin National Institutes of Health
Johannes N. Spelbrink
Johannes N. Spelbrink Radboud University
Andrew P. Jackson
Andrew P. Jackson University of Edinburgh

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