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Maria Falkenberg

Maria Falkenberg

D-Index & Metrics

Genetics

D-Index
59
Citations
16193
World Ranking
3217
National Ranking
40

Overview

Maria Falkenberg is affiliated with the University of Gothenburg in Sweden and specializes in the field of Biochemistry, Genetics and Molecular Biology, with a primary focus on Molecular Biology. Their research encompasses several subfields, including Clinical Biochemistry, Genetics, Cellular and Molecular Neuroscience, and Immunology.

The scientist's work covers a diverse range of topics, notably Mitochondrial Function and Pathology, ATP Synthase and ATPases Research, Metabolism and Genetic Disorders, RNA modifications and cancer, DNA Repair Mechanisms, Ubiquitin and proteasome pathways, and Cancer therapeutics and mechanisms.

Among the recent research publications are:

  • Small-molecule inhibitors of human mitochondrial DNA transcription, 2020, Nature
  • Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing, 2020, PLoS Genetics
  • The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication, 2021, Science Advances
  • Mechanisms and regulation of human mitochondrial transcription, 2023, Nature Reviews Molecular Cell Biology
  • TWINKLE and Other Human Mitochondrial DNA Helicases: Structure, Function and Disease, 2020, Genes

Frequent co-authors collaborating with Maria Falkenberg include Bradley Peter, Claes M. Gustafsson, Bertil Macao, Sebastian Valenzuela, and Thomas J. Nicholls.

The preferred venues for publishing research comprise Nucleic Acids Research, Nature, Nature Communications, Cell, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Premature ageing in mice expressing defective mitochondrial DNA polymerase

    Aleksandra Trifunovic;Anna Wredenberg;Maria Falkenberg;Johannes N. Spelbrink

  • Mitochondrial transcription factor A regulates mtDNA copy number in mammals

    Mats I. Ekstrand;Maria Falkenberg;Anja Rantanen;Chan Bae Park

  • DNA Replication and Transcription in Mammalian Mitochondria

    Maria Falkenberg;Nils-Göran Larsson;Claes M. Gustafsson

  • Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA

    Maria Falkenberg;Martina Gaspari;Anja Rantanen;Aleksandra Trifunovic

  • Maintenance and Expression of Mammalian Mitochondrial DNA

    Claes M Gustafsson;Maria Falkenberg;Nils-Göran Larsson

  • Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

    Christian Kukat;Christian A. Wurm;Henrik Spåhr;Maria Falkenberg

  • Reconstitution of a minimal mtDNA replisome in vitro.

    Jenny A Korhonen;Xuan Hoi Pham;Mina Pellegrini;Maria Falkenberg

  • Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

    Christian Kukat;Karen M. Davies;Christian A. Wurm;Henrik Spåhr

  • TWINKLE Has 5′ → 3′ DNA Helicase Activity and Is Specifically Stimulated by Mitochondrial Single-stranded DNA-binding Protein

    Jenny A. Korhonen;Martina Gaspari;Maria Falkenberg

  • Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging

    Joost van Mameren;Peter Gross;Geraldine Farge;Pleuni Hooijman

  • MTERF3 Is a Negative Regulator of Mammalian mtDNA Transcription

    Chan Bae Park;Jorge Asin-Cayuela;Yolanda Cámara;Yonghong Shi

  • Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication

    Javier Miralles Fusté;Sjoerd Wanrooij;Elisabeth Jemt;Caroline E. Granycome

  • Human Mitochondrial Transcription Revisited ONLY TFAM AND TFB2M ARE REQUIRED FOR TRANSCRIPTION OF THE MITOCHONDRIAL GENES IN VITRO

    Dmitry Litonin;Marina Sologub;Yonghong Shi;Maria Savkina

  • Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro

    Sjoerd Wanrooij;Javier Miralles Fusté;Géraldine Farge;Yonghong Shi;Yonghong Shi

  • Mammalian transcription factor A is a core component of the mitochondrial transcription machinery

    Yonghong Shi;Anke Dierckx;Paulina H. Wanrooij;Sjoerd Wanrooij

  • The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.

    Martina Gaspari;Maria Falkenberg;Nils-Göran Larsson;Claes M Gustafsson

  • G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation

    Paulina H. Wanrooij;Jay P. Uhler;Tomas Simonsson;Maria Falkenberg

  • A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

    Paulina H. Wanrooij;Jay P. Uhler;Yonghong Shi;Fredrik Westerlund

  • TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

    Dusanka Milenkovic;Stanka Matic;Inge Kühl;Benedetta Ruzzenente

  • Small-molecule inhibitors of human mitochondrial DNA transcription.

    Nina A. Bonekamp;Bradley Peter;Hauke S. Hillen;Andrea Felser

Frequent Co-Authors

Claes M. Gustafsson
Claes M. Gustafsson University of Gothenburg
Nils-Göran Larsson
Nils-Göran Larsson Karolinska Institute
Anders Oldfors
Anders Oldfors University of Gothenburg
Rolf Wibom
Rolf Wibom Karolinska Institute
Anna Wedell
Anna Wedell Karolinska University Hospital
Gijs J. L. Wuite
Gijs J. L. Wuite Vrije Universiteit Amsterdam
Robert W. Taylor
Robert W. Taylor Newcastle University
Massimo Zeviani
Massimo Zeviani University of Padua
Aleksandra Filipovska
Aleksandra Filipovska University of Western Australia
Nicholas Katsanis
Nicholas Katsanis Galatea Bio Inc

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