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Biology and Biochemistry

D-Index
73
Citations
30764
World Ranking
5801
National Ranking
2744

Overview

Tomas A. Prolla is affiliated with the University of Wisconsin-Madison in the United States. Their research primarily focuses on fields within Medicine and Biochemistry, Genetics, and Molecular Biology, with notable contributions to subfields such as Physiology, Molecular Biology, Cancer Research, Geriatrics and Gerontology, and Endocrinology, Diabetes, and Metabolism.

The main topics covered in Tomas A. Prolla's work include:

  • Adipose Tissue and Metabolism
  • Sirtuins and Resveratrol in Medicine
  • Biochemical effects in animals
  • Genetics, Aging, and Longevity in Model Organisms
  • Osteoarthritis Treatment and Mechanisms
  • Cancer-related molecular mechanisms research
  • Thyroid Cancer Diagnosis and Treatment

They have authored research papers published in a variety of scientific venues. Some frequent publication outlets include:

  • Scientific Reports
  • Aging Cell
  • Modern Pathology
  • Frontiers in Genetics
  • Nutrients

Significant recent papers authored or coauthored by Tomas A. Prolla include:

  • Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features, 2020, Scientific Reports
  • SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction, 2022, Aging Cell
  • Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition, 2020, Frontiers in Genetics
  • Somatostatin Receptor Type 2 and Thyroid-Stimulating Hormone Receptor Expression in Oncocytic Thyroid Neoplasms: Implications for Prognosis and Treatment, 2023, Modern Pathology
  • A Novel Micronutrient Blend Mimics Calorie Restriction Transcriptomics in Multiple Tissues of Mice and Increases Lifespan and Mobility in C. elegans, 2020, Nutrients

Tomas A. Prolla frequently collaborates with several researchers. Some of the most frequent coauthors include:

  • Paul R. van Ginkel
  • Fúlvia de Barros Manchado-Gobatto
  • Cláudio Alexandre Gobatto
  • Gregory C. Kujoth
  • Rashpal S. Dhillon

Best Publications

  • Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

    G. C. Kujoth;A. Hiona;T. D. Pugh;S. Someya

  • Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

    Cheol Koo Lee;Roger G. Klopp;Richard Weindruch;Tomas A. Prolla

  • Gene-expression profile of the ageing brain in mice.

    Cheol Koo Lee;Richard Weindruch;Tomas A. Prolla

  • SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie

  • Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.

    Hsiuchen Chen;Marc Vermulst;Yun E. Wang;Anne Chomyn

  • Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

    Shinichi Someya;Shinichi Someya;Wei Yu;William C. Hallows;Jinze Xu

  • SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

    Philipp Oberdoerffer;Shaday Michan;Michael McVay;Raul Mostoslavsky

  • THE SELENOPROTEIN GPX4 IS ESSENTIAL FOR MOUSE DEVELOPMENT AND PROTECTS FROM RADIATION AND OXIDATIVE DAMAGE INSULTS

    Levi J Yant;Qitao Ran;Lin Rao;Holly Van Remmen

  • A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

    Jamie L. Barger;Tsuyoshi Kayo;James M. Vann;Edward B. Arias

  • Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

    Alexander S. Hebert;Kristin E. Dittenhafer-Reed;Wei Yu;Derek J. Bailey

  • Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

    Dao Fu Dai;Simon C. Johnson;Jason J. Villarin;Michael T. Chin

  • Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

    Tsuyoshi Kayo;David B. Allison;Richard Weindruch;Tomas A. Prolla

  • Mitochondrial point mutations do not limit the natural lifespan of mice

    Marc Vermulst;Jason H Bielas;Gregory C Kujoth;Warren C Ladiges

  • DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.

    Marc Vermulst;Jonathan Wanagat;Gregory C Kujoth;Jason H Bielas

  • Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair

    T. A. Prolla;S. M. Baker;A. C. Harris;J.-L. Tsao

  • Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

    William C. Hallows;Wei Yu;Brian C. Smith;Mark K. Devries

  • Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts.

    Cheol-Koo Lee;David B. Allison;Jaap Brand;Richard Weindruch

  • Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

    Adeel Safdar;Jacqueline M. Bourgeois;Daniel I. Ogborn;Jonathan P. Little

  • Microarray Profiling of Gene Expression in Aging and Its Alteration by Caloric Restriction in Mice

    Richard Weindruch;Tsuyoshi Kayo;Cheol Koo Lee;Tomas A. Prolla

  • Evolution of the Aging Brain Transcriptome and Synaptic Regulation

    Patrick M. Loerch;Tao Lu;Kelly A. Dakin;James M. Vann

Frequent Co-Authors

Richard Weindruch
Richard Weindruch University of Wisconsin–Madison
Mark A. Tarnopolsky
Mark A. Tarnopolsky McMaster University
Christiaan Leeuwenburgh
Christiaan Leeuwenburgh University of Florida
Masaru Tanokura
Masaru Tanokura University of Tokyo
David B. Allison
David B. Allison Indiana University
John M. Denu
John M. Denu University of Wisconsin–Madison
Peter S. Rabinovitch
Peter S. Rabinovitch University of Washington
Carlos T. Moraes
Carlos T. Moraes University of Miami
Arlan Richardson
Arlan Richardson University of Oklahoma Health Sciences Center
Jason D. Morrow
Jason D. Morrow Vanderbilt University

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