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Genetics

D-Index
132
Citations
57732
World Ranking
241
National Ranking
124

Research.com Recognitions

  • 2013 - National Institutes of Health Director's Pioneer Award
  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Vadim N. Gladyshev is affiliated with Brigham and Women's Hospital in the United States. Their research spans primarily the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions also in Medicine. Within these broader fields, their subfields of study include Molecular Biology, Aging, Physiology, Nutrition and Dietetics, and Genetics.

Gladyshev's research focuses on several key topics:

  • Genetics, Aging, and Longevity in Model Organisms
  • Epigenetics and DNA Methylation
  • Birth, Development, and Health
  • RNA modifications and cancer
  • Pluripotent Stem Cells Research
  • Dietary Effects on Health
  • CRISPR and Genetic Engineering

The scientist has a substantial publication record, frequently contributing to venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Aging, Aging Cell, Nature Communications, and Innovation in Aging. Their recent papers include:

  • "Reprogramming to recover youthful epigenetic information and restore vision," 2020, Nature
  • "Loss of epigenetic information as a cause of mammalian aging," 2023, Cell
  • "Biomarkers of aging for the identification and evaluation of longevity interventions," 2023, Cell
  • "Universal DNA methylation age across mammalian tissues," 2023, Nature Aging
  • "Validation of biomarkers of aging," 2024, Nature Medicine

In collaboration, Vadim N. Gladyshev frequently coauthors with several researchers, including Alexander Tyshkovskiy, Steve Horvath, Mahdi Moqri, Kejun Ying, and Vera Gorbunova. These partnerships have resulted in numerous joint publications, indicating active involvement in a collaborative scientific community.

Among recognized honors, Gladyshev received the National Institutes of Health Director's Pioneer Award in 2013 and was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010.

Best Publications

  • The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions

    Sabeeha S. Merchant;Simon E. Prochnik;Olivier Vallon;Elizabeth H. Harris

  • Characterization of Mammalian Selenoproteomes

    Gregory V. Kryukov;Sergi Castellano;Sergey V. Novoselov;Sergey V. Novoselov;Alexey V. Lobanov;Alexey V. Lobanov

  • Selenoproteins: molecular pathways and physiological roles.

    Vyacheslav M. Labunskyy;Dolph L. Hatfield;Vadim N. Gladyshev

  • How selenium has altered our understanding of the genetic code.

    Dolph L. Hatfield;Vadim N. Gladyshev

  • Reprogramming to recover youthful epigenetic information and restore vision.

    Yuancheng Lu;Benedikt Brommer;Benedikt Brommer;Xiao Tian;Anitha Krishnan

  • DNA methylation aging clocks: challenges and recommendations

    Christopher G Bell;Robert Lowe;Peter D Adams;Peter D Adams;Andrea A Baccarelli

  • Crystal Structure of Formate Dehydrogenase H: Catalysis Involving Mo, Molybdopterin, Selenocysteine, and an Fe4S4 Cluster

    Jeffrey C. Boyington;Vadim N. Gladyshev;Sergei V. Khangulov;Thressa C. Stadtman

  • Selenium and selenocysteine: roles in cancer, health, and development

    Dolph L. Hatfield;Petra A. Tsuji;Bradley A. Carlson;Vadim N. Gladyshev

  • Genome sequencing reveals insights into physiology and longevity of the naked mole rat

    Eun Bae Kim;Xiaodong Fang;Alexey A. Fushan;Zhiyong Huang

  • Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

    Vadim N. Gladyshev;Kuan-Teh Jeang;Thressa C. Stadtman

  • Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

    Christopher Hine;Eylul Harputlugil;Yue Zhang;Christoph Ruckenstuhl

  • Pan genome of the phytoplankton Emiliania underpins its global distribution

    Betsy A. Read;Jessica Kegel;Mary J. Klute;Alan Kuo

  • Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.

    Qi An Sun;Yalin Wu;Francesca Zappacosta;Kuan Teh Jeang

  • Biosynthesis of selenocysteine on its tRNA in eukaryotes

    Xue-Ming Xu;Bradley A. Carlson;Heiko Mix;Yan Zhang

  • Eukaryotic Selenoproteins and Selenoproteomes

    Alexey V. Lobanov;Dolph L. Hatfield;Vadim N. Gladyshev

  • Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces.

    Stefano M. Marino;Vadim N. Gladyshev

  • Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

    Qi An Sun;Leo Kirnarsky;Simon Sherman;Vadim N. Gladyshev

  • LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

    Matthew Simon;Michael Van Meter;Julia Ablaeva;Zhonghe Ke

  • Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions

    Daniel A. Petkovich;Dmitriy I. Podolskiy;Alexei V. Lobanov;Sang Goo Lee

  • Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii

    Sergey V. Novoselov;Mahadev Rao;Natalia V. Onoshko;Huijun Zhi

Frequent Co-Authors

Dolph L. Hatfield
Dolph L. Hatfield National Institutes of Health
Bradley A. Carlson
Bradley A. Carlson National Institutes of Health
Vera Gorbunova
Vera Gorbunova University of Rochester
Gregory V. Kryukov
Gregory V. Kryukov Broad Institute
Andrei Seluanov
Andrei Seluanov University of Rochester
Jan Vijg
Jan Vijg Albert Einstein College of Medicine
Ulrich Schweizer
Ulrich Schweizer University of Bonn
Thressa C. Stadtman
Thressa C. Stadtman National Institutes of Health
Roderic Guigó
Roderic Guigó Pompeu Fabra University
Steven P. Gygi
Steven P. Gygi Harvard University

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