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Biology and Biochemistry

D-Index
67
Citations
31274
World Ranking
8043
National Ranking
3646

Overview

Andrew E. Jaffe is affiliated with Johns Hopkins University in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with a particular emphasis on Molecular Biology, Genetics, and Cellular and Molecular Neuroscience. Contributions also extend to Cancer Research and Neurology.

The scientist's work covers several main research topics, including:

  • Genetic Associations and Epidemiology
  • Epigenetics and DNA Methylation
  • Single-cell and spatial transcriptomics
  • RNA modifications and cancer
  • Genetics and Neurodevelopmental Disorders
  • Cancer-related molecular mechanisms research
  • Genetic Syndromes and Imprinting

Recent papers authored or co-authored by Andrew E. Jaffe include:

  • Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex, 2021, published in Nature Neuroscience
  • recount3: summaries and queries for large-scale RNA-seq expression and splicing, 2021, Genome Biology
  • Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain, 2021, Neuron
  • Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs, 2020, Nature Communications
  • A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder, 2020, Nature Neuroscience

Their frequent co-authors are:

  • Thomas M. Hyde (46 joint publications)
  • Leonardo Collado-Torres (41)
  • Joel E. Kleinman (41)
  • Daniel R. Weinberger (40)
  • Keri Martinowich (33)

Andrew E. Jaffe has published extensively in specific venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory) - 29 publications
  • Nature Neuroscience - 11 publications
  • Nature Communications - 5 publications
  • Molecular Psychiatry - 5 publications
  • Biological Psychiatry - 5 publications

Their publication record reflects a strong focus on genetics, molecular neuroscience, and mechanisms underlying neurodevelopmental and cancer-related disorders. The contributions to transcriptomics, particularly single-cell and spatial approaches, are evident through both their topics of study and selected high-impact papers.

Best Publications

  • The sva package for removing batch effects and other unwanted variation in high-throughput experiments

    Jeffrey T. Leek;W. Evan Johnson;Hilary S. Parker;Andrew E. Jaffe

  • Minfi: A flexible and comprehensive Bioconductor package for the analysis of Infinium DNA Methylation microarrays

    Martin J. Aryee;Andrew E. Jaffe;Hector Corrada-Bravo;Christine Ladd-Acosta

  • DNA methylation age of blood predicts all-cause mortality in later life.

    Riccardo E Marioni;Riccardo E Marioni;Sonia Shah;Allan F McRae;Brian H Chen

  • Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

    Michael J. Gandal;Pan Zhang;Evi Hadjimichael;Rebecca L. Walker

  • Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex.

    Kristen R. Maynard;Leonardo Collado-Torres;Lukas M. Weber;Cedric Uytingco

  • Accounting for cellular heterogeneity is critical in epigenome-wide association studies

    Andrew E Jaffe;Rafael A Irizarry

  • Comprehensive functional genomic resource and integrative model for the human brain

    Daifeng Wang;Daifeng Wang;Shuang Liu;Jonathan Warrell;Hyejung Won

  • Ballgown bridges the gap between transcriptome assembly and expression analysis.

    Alyssa C Frazee;Geo Pertea;Andrew E Jaffe;Ben Langmead

  • Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies.

    Andrew E Jaffe;Peter Murakami;Hwajin Lee;Jeffrey T Leek

  • Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

    Kristen Maynard;Leonardo Collado Torres;Lukas M Weber;Cedric Uytingco

  • Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

    Andrew E Jaffe;Yuan Gao;Amy Deep-Soboslay;Ran Tao

  • Reproducible RNA-seq analysis using recount2.

    Leonardo Collado-Torres;Abhinav Nellore;Kai Kammers;Kai Kammers;Shannon E Ellis

  • The PsychENCODE project

    Schahram Akbarian;Chunyu Liu;James A Knowles;Flora M Vaccarino

  • Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

    Santhi K. Ganesh;Santhi K. Ganesh;Neil A. Zakai;Frank J A Van Rooij;Nicole Soranzo;Nicole Soranzo

  • Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis.

    Andrew E Jaffe;Richard E Straub;Joo Heon Shin;Ran Tao

  • Polyester: simulating RNA-seq datasets with differential transcript expression

    Alyssa C. Frazee;Andrew E. Jaffe;Ben Langmead;Jeffrey T. Leek

  • Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

    Michael J. McConnell;John V. Moran;Alexej Abyzov;Schahram Akbarian

  • Convergence of placenta biology and genetic risk for schizophrenia.

    Gianluca Ursini;Gianluca Ursini;Gianluca Ursini;Giovanna Punzi;Giovanna Punzi;Qiang Chen;Stefano Marenco

  • A Bayesian framework for multiple trait colocalization from summary association statistics.

    Claudia Giambartolomei;Jimmy Zhenli Liu;Wen Zhang;Mads Hauberg;Mads Hauberg

  • Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds.

    Rafael Guerrero-Preston;Lynn R. Goldman;Priscilla Brebi-Mieville;Carmen Ili-Gangas

Frequent Co-Authors

Joel E. Kleinman
Joel E. Kleinman Johns Hopkins University
Thomas M. Hyde
Thomas M. Hyde Johns Hopkins University
Daniel R. Weinberger
Daniel R. Weinberger Johns Hopkins University
Jeffrey T. Leek
Jeffrey T. Leek Fred Hutchinson Cancer Research Center
Keri Martinowich
Keri Martinowich Johns Hopkins University
Ben Langmead
Ben Langmead Johns Hopkins University
Rafael A. Irizarry
Rafael A. Irizarry Harvard University
Nicholas J. Brandon
Nicholas J. Brandon Neumora Therapeutics Inc
Andrew P. Feinberg
Andrew P. Feinberg Johns Hopkins University
Kasper D. Hansen
Kasper D. Hansen Johns Hopkins University

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