Henrik Klitgaard

Overview

Best Publications

• New avenues for anti-epileptic drug discovery and development

  Wolfgang Löscher;Henrik Klitgaard;Roy E. Twyman;Dieter Schmidt

  725
  Citations

• Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.

  Henrik Klitgaard;Alain Matagne;Jean Gobert;Ernst Wülfert

  724
  Citations

• The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents

  Jean-Michel Rigo;Grégory Hans;Laurent Nguyen;Véronique Rocher

  408
  Citations

• Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity.

  Benoit M Kenda;Alain C Matagne;Patrice E Talaga;Patrick M Pasau

  363
  Citations

• Levetiracetam inhibits the high-voltage-activated Ca2+ current in pyramidal neurones of rat hippocampal slices

  Isabelle Niespodziany;Henrik Klitgaard;Doru Georg Margineanu

  302
  Citations

• Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

  Pavel Klein;Raymond Dingledine;Eleonora Aronica;Christophe Bernard

  297
  Citations

• Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A

  Alain Matagne;D-G Margineanu;Benoît Kenda;Philippe Michel

  294
  Citations

• SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy.

  Rafal M. Kaminski;Alain Matagne;Karine Leclercq;Michel Gillard

  225
  Citations

• Levetiracetam does not modulate neuronal voltage-gated Na+and T-type Ca2+currents

  Cristina Zona;Isabelle Niespodziany;Caterina Marchetti;Henrik Klitgaard

  210
  Citations

• Levetiracetam: the preclinical profile of a new class of antiepileptic drugs?

  Henrik Klitgaard

  207
  Citations

• Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action?

  Michael Madeja;Doru Georg Margineanu;Ali Gorji;Elke Siep

  188
  Citations

• Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment

  Henrik Klitgaard;Alain Matagne;Jean-Marie Nicolas;Michel Gillard

  186
  Citations

• Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man

  Alain Matagne;Henrik Klitgaard

  178
  Citations

• Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond

  Wolfgang Löscher;Michel Gillard;Zara A. Sands;Rafal M. Kaminski

  176
  Citations

• Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs

  Doru Georg Margineanu;Henrik Klitgaard

  170
  Citations

• Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.

  Jean‐Marie Nicolas;Jonas Hannestad;Daniel Holden;Sophie Kervyn

  167
  Citations

• Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia

  Etienne Hanon;Henrik Klitgaard

  162
  Citations

• Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.

  Rafal M. Kaminski;Michel Gillard;Karine Leclercq;Etienne Hanon

  149
  Citations

• Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracelullar striatal dopamine

  Wassilios Meissner;Paula Ravenscroft;René Reese;René Reese;Daniel Harnack

  142
  Citations

• Pilocarpine-induced epileptogenesis in the rat:: Impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations

  Henrik Klitgaard;Alain Matagne;Jocelyne Vanneste-Goemaere;Doru-Georg Margineanu

  139
  Citations

• Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus.

  Andrey M Mazarati;Roger Baldwin;Henrik Klitgaard;Alain Matagne

  132
  Citations