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Jonathan M. Brotchie

Jonathan M. Brotchie

D-Index & Metrics

Medicine

D-Index
86
Citations
19813
World Ranking
14318
National Ranking
599

Overview

Jonathan M. Brotchie is affiliated with the University Health Network in Canada and has a primary focus on Medicine and Neuroscience, with extensive contributions spanning 36 publications in Medicine and 22 in Neuroscience. Their research particularly emphasizes Neurology, where they have contributed to 36 works, alongside Cellular and Molecular Neuroscience with 14 publications, and Molecular Biology with 8.

Brotchie's research concentrates on several key areas within neurological science. The main topics of their work include:

  • Parkinson's Disease Mechanisms and Treatments
  • Neurological disorders and treatments
  • Nerve injury and regeneration
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Cell Adhesion Molecules Research
  • RNA regulation and disease

Their recent publications demonstrate a focus on Parkinson's disease and neurodegenerative processes. Notable recent papers include:

  • "Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein" (2020), published in Acta Neuropathologica Communications
  • "Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson's disease mice" (2022), published in Brain Behavior and Immunity
  • "The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson's Disease" (2020), published in Cells
  • "The selective 5-HT1A receptor agonist, NLX-112, exerts anti-dyskinetic effects in MPTP-treated macaques" (2020), published in Parkinsonism & Related Disorders
  • "NYX-458 Improves Cognitive Performance in a Primate Parkinson's Disease Model" (2020), published in Movement Disorders

Brotchie frequently collaborates with several researchers, including James B. Koprich, with whom they have co-authored 15 publications. Other frequent co-authors include Jens Volkmann and Chi Wang Ip, each with 10 collaborative works, Tom H. Johnston with 6, and Rhonda L. McFleder with 4.

Their research has been published across various scientific journals, with several works appearing in Clinical Neurophysiology (3 publications), Brain Behavior and Immunity (2), Journal of Neuroinflammation (2), Neuropharmacology (2), and Acta Neuropathologica Communications (1).

Best Publications

  • Relationship between the Appearance of Symptoms and the Level of Nigrostriatal Degeneration in a Progressive 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease

    Erwan Bezard;Erwan Bezard;Sandra Dovero;Caroline Prunier;Paula Ravenscroft

  • Pathophysiology of levodopa-induced dyskinesia: Potential for new therapies

    Erwan Bezard;Jonathan M. Brotchie;Christian E. Gross

  • Levodopa-induced dyskinesias.

    Giovanni Fabbrini;Jonathan M. Brotchie;Francisco Grandas;Masahiro Nomoto

  • Presymptomatic compensation in Parkinson's disease is not dopamine-mediated

    Erwan Bezard;Christian E. Gross;Jonathan M. Brotchie

  • Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.

    K.A. Sieradzan;S.H. Fox;M. Hill;J.P.R. Dick

  • Novel pharmacological targets for the treatment of Parkinson's disease

    Anthony H V Schapira;Erwan Bezard;Jonathan Brotchie;Frédéric Calon

  • The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease

    Philippe Huot;Tom H. Johnston;James B. Koprich;Susan H. Fox

  • Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease.

    Vincenzo Di Marzo;Michael P. Hill;Tiziana Bisogno;Alan R. Crossman

  • Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate.

    Jonathan M. Brotchie;Ian J. Mitchell;Michael A. Sambrook;Alan R. Crossman

  • Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.

    Brian Henry;Alan R. Crossman;Jonathan M. Brotchie

  • Nondopaminergic mechanisms in levodopa-induced dyskinesia.

    Jonathan M. Brotchie

  • Animal models of α-synucleinopathy for Parkinson disease drug development

    James B. Koprich;Lorraine V. Kalia;Jonathan M. Brotchie

  • CB1 cannabinoid receptor signalling in Parkinson's disease.

    Jonathan M Brotchie

  • Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

    Penelope J. Hallett;A.W. Dunah;Paula Ravenscroft;Shaobo Zhou

  • The serotonergic system in Parkinson's disease.

    Philippe Huot;Susan H. Fox;Jonathan M. Brotchie

  • On the role of enkephalin cotransmission in the GABAergic striatal efferents to the globus pallidus

    Yannick P. Maneuf;Ian J. Mitchell;Alan R. Crossman;Jonathan M. Brotchie

  • Effect of repeated L-DOPA, bromocriptine, or lisuride administration on preproenkephalin-A and preproenkephalin-B mRNA levels in the striatum of the 6-hydroxydopamine-lesioned rat.

    Brian Henry;Alan R. Crossman;Jonathan M. Brotchie

  • A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease.

    Mario van der Stelt;Susan H. Fox;Michael Hill;Alan R. Crossman

  • Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

    Juha-Matti Savola;Michael Hill;Mia Engstrom;Hannele Merivuori

  • Levodopa-induced dyskinesia in Parkinson’s disease

    J. M. Brotchie;J. Lee;K. Venderova

Frequent Co-Authors

Alan R. Crossman
Alan R. Crossman University of Manchester
James B. Koprich
James B. Koprich Fudan University
Erwan Bezard
Erwan Bezard University of Bordeaux
Mark J. Millan
Mark J. Millan University of Glasgow
Anthony E. Lang
Anthony E. Lang University of Toronto
Christian E. Gross
Christian E. Gross University of Bordeaux
Henrik Klitgaard
Henrik Klitgaard UCB Pharma (Belgium)
Jens Volkmann
Jens Volkmann University of Würzburg
Penelope J. Hallett
Penelope J. Hallett Harvard University
James H. Eubanks
James H. Eubanks University Health Network

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