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Laurent Grégoire

Laurent Grégoire

D-Index & Metrics

Neuroscience

D-Index
36
Citations
4598
World Ranking
9056
National Ranking
533

Overview

Laurent Grégoire is affiliated with Université Laval in Canada and focuses on research in the fields of medicine and neuroscience. Their work lies primarily within the subfields of neurology and cellular and molecular neuroscience, addressing topics related to neuroscience and neuropharmacology research, neurological disorders and treatments, and mechanisms and treatments of Parkinson's disease.

Grégoire has published in the journal Cells, with documented work involving collaborations with various coauthors. Notable frequent collaborators include Mélanie Bourque, Waseema Patel, David Dickens, Ralph Snodgrass, and Thérèse Di Paolo.

Among Grégoire's recent research contributions is the publication titled "AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys", published in 2022 in Cells.

This publication examines the pharmacological effects of AV-101 on Parkinsonian dyskinesias through modulation of NMDA receptor activity, reflecting Grégoire's focus on therapeutic approaches in neurological conditions.

The main topics associated with their research are:

  • Neuroscience and Neuropharmacology Research
  • Neurological disorders and treatments
  • Parkinson's Disease Mechanisms and Treatments

Frequent coauthors collaborating with Grégoire include:

  • Mélanie Bourque
  • Waseema Patel
  • David Dickens
  • Ralph Snodgrass
  • Thérèse Di Paolo

The primary publication venue is:

  • Cells

Grégoire's research contributions emphasize exploring the molecular and clinical aspects of neurological diseases, particularly Parkinson's disease, integrating pharmacological insights relevant to improving treatment outcomes.

Best Publications

  • Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys.

    R. Grondin;P.J. Bédard;A. Hadj Tahar;L. Grégoire

  • Effect of a selective glutamate antagonist on L-dopa-induced dyskinesias in drug-naive parkinsonian monkeys.

    Abdallah Hadj Tahar;Laurent Grégoire;Aurélie Darré;Nancy Bélanger

  • The past, present, and future of selection history.

    Brian A. Anderson;Haena Kim;Andy J. Kim;Ming-Ray Liao

  • mGluR5 metabotropic glutamate receptors and dyskinesias in MPTP monkeys

    Pershia Samadi;Laurent Grégoire;Marc Morissette;Fréderic Calon

  • Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys.

    Nicolas Morin;Laurent Grégoire;Baltazar Gomez-Mancilla;Fabrizio Gasparini

  • Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys

    Pershia Samadi;Laurent Grégoire;Claude Rouillard;Paul J. Bédard

  • Risk factors for peak dose dyskinesia in 100 levodopa-treated parkinsonian patients.

    Pierre J. Blanchet;Pierre Allard;Laurent Grégoire;François Tardif

  • Low doses of sarizotan reduce dyskinesias and maintain antiparkinsonian efficacy of L-Dopa in parkinsonian monkeys.

    Laurent Grégoire;Pershia Samadi;Julie Graham;Paul J. Bédard

  • The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in l-Dopa-treated parkinsonian monkeys

    Laurent Grégoire;Nicolas Morin;Bazoumana Ouattara;Fabrizio Gasparini

  • Metabotropic glutamate receptor type 5 in levodopa-induced motor complications.

    Bazoumana Ouattara;Laurent Grégoire;Marc Morissette;Fabrizio Gasparini

  • Preladenant, a selective A2A receptor antagonist, is active in primate models of movement disorders

    Robert A. Hodgson;Paul J. Bedard;Geoffrey B. Varty;Tatiana M. Kazdoba

  • Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

    Laurent Grégoire;Arash Rassoulpour;Paolo Guidetti;Pershia Samadi

  • Sustained cabergoline treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys.

    Abdallah Hadj Tahar;Laurent Gregoire;Evelyne Bangassoro;Paul J. Bedard

  • Basal ganglia group II metabotropic glutamate receptors specific binding in non-human primate model of L-Dopa-induced dyskinesias.

    Pershia Samadi;Laurent Grégoire;Marc Morissette;Fréderic Calon

  • Opioid antagonists increase the dyskinetic response to dopaminergic agents in parkinsonian monkeys: interaction between dopamine and opioid systems.

    Pershia Samadi;Laurent Grégoire;Paul J Bédard

  • Safinamide reduces dyskinesias and prolongs L-DOPA antiparkinsonian effect in parkinsonian monkeys.

    Laurent Grégoire;Vincent A. Jourdain;Matthew Townsend;Arthur Roach

  • Correlation of functional recovery after a 6-hydroxydopamine lesion with survival of grafted fetal neurons and release of dopamine in the striatum of the rat

    L. Rioux;D.P. Gaudin;L.K. Bui;L. Grégoire

  • Relevance of the MPTP primate model in the study of dyskinesia priming mechanisms.

    Pierre J Blanchet;Frédéric Calon;Marc Morissette;Abdallah Hadj Tahar

  • D1 receptor blockade improves L-dopa-induced dyskinesia but worsens parkinsonism in MPTP monkeys.

    Richard Grondin;Van Diep Doan;Laurent Grégoire;Paul J. Bédard

  • MPEP, an mGlu5 receptor antagonist, reduces the development of L-DOPA-induced motor complications in de novo parkinsonian monkeys: biochemical correlates.

    Nicolas Morin;Laurent Grégoire;Marc Morissette;Sandrine Desrayaud

  • 5-HT1 receptors mediating contraction in bovine cerebral arteries: a model for human cerebrovascular ‘5-HT1Dβ‘ receptors

    Edith Hamel;Lyne Grégoire;Benjamin Lau

  • Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys.

    Nicolas Morin;Marc Morissette;Laurent Grégoire;Baltazar Gomez-Mancilla

Frequent Co-Authors

Paul J. Bédard
Paul J. Bédard Université Laval
Marc Morissette
Marc Morissette Université Laval
Pierre Perruchet
Pierre Perruchet University of Burgundy
Frédéric Calon
Frédéric Calon Université Laval
Claude Rouillard
Claude Rouillard Université Laval
Martin Parent
Martin Parent Université Laval
Richard Grondin
Richard Grondin University of Kentucky
Mara Mather
Mara Mather University of Southern California
André Parent
André Parent Université Laval

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