Sakari Kauppinen mainly focuses on microRNA, Gene silencing, Gene expression, Molecular biology and Locked nucleic acid. MicroRNA is a subfield of Genetics that Sakari Kauppinen studies. His research in Gene silencing intersects with topics in Cancer and MiR-122.
The Gene expression study combines topics in areas such as Oligonucleotide and Zebrafish. The concepts of his Molecular biology study are interwoven with issues in Gene and In vivo. The Locked nucleic acid study which covers RNA interference that intersects with Gene Knockdown Techniques, Functional genomics and Three prime untranslated region.
Sakari Kauppinen focuses on microRNA, Molecular biology, Gene expression, Gene silencing and Computational biology. The various areas that he examines in his microRNA study include Cancer, Cancer research, Oligonucleotide and Cell biology. His Molecular biology study combines topics in areas such as Cell culture, Stromal cell, In situ hybridization, MiR-122 and Long non-coding RNA.
In the subject of general Gene expression, his work in Gene expression profiling is often linked to Fluorescence in situ hybridization, thereby combining diverse domains of study. Within one scientific family, he focuses on topics pertaining to RNA interference under Gene silencing, and may sometimes address concerns connected to Three prime untranslated region. His research in Computational biology focuses on subjects like Transcriptome, which are connected to Phenotype.
His primary areas of investigation include Cancer research, Computational biology, RNA, microRNA and Myeloid leukemia. His work carried out in the field of Cancer research brings together such families of science as Cancer, Gene silencing, Transthyretin and RNA interference. His studies deal with areas such as Functional annotation, Transcriptome, Gene knockdown and Non-coding RNA as well as Computational biology.
His research in Transcriptome tackles topics such as Phenotype which are related to areas like Cell growth and Gene expression. His study in RNA is interdisciplinary in nature, drawing from both Messenger RNA and Cell biology. Sakari Kauppinen combines microRNA and Nonalcoholic steatohepatitis in his studies.
His scientific interests lie mostly in RNA, Gene, Computational biology, Cell biology and Messenger RNA. In general Gene study, his work on Gene knockdown often relates to the realm of Famine and Thrifty phenotype, thereby connecting several areas of interest. In his work, Gene expression, Biological pathway and Functional annotation is strongly intertwined with Cell growth, which is a subfield of Computational biology.
His Gene expression study is associated with Genetics. His work deals with themes such as Ribosomal RNA, Myeloid leukemia, Long non-coding RNA and Protein biosynthesis, which intersect with Cell biology. His research integrates issues of Carcinogenesis, Regulation of gene expression, Transcription factor and Exon in his study of Messenger RNA.
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Treatment of HCV infection by targeting microRNA
Harry L A Janssen;Hendrik W Reesink;Eric J Lawitz;Stefan Zeuzem.
The New England Journal of Medicine (2013)
Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
Robert E. Lanford;Elisabeth S. Hildebrandt-Eriksen;Andreas Petri;Robert Persson.
LNA-mediated microRNA silencing in non-human primates
Joacim Elmén;Morten Lindow;Sylvia Schütz;Matthew Lawrence.
MicroRNA Expression in Zebrafish Embryonic Development
Erno Wienholds;Wigard P. Kloosterman;Eric Miska;Eric Miska;Ezequiel Alvarez-Saavedra.
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.
Sébastien S. Hébert;Katrien Horré;Laura Nicolaï;Aikaterini S. Papadopoulou.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes
Anna Válóczi;Csaba Hornyik;Nóra Varga;József Burgyán.
Nucleic Acids Research (2004)
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
Joacim Elmén;Morten Lindow;Asli Silahtaroglu;Mads Bak.
Nucleic Acids Research (2008)
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes
Wigard P Kloosterman;Erno Wienholds;Ewart de Bruijn;Sakari Kauppinen.
Nature Methods (2006)
Altered MicroRNA Expression Confined to Specific Epithelial Cell Subpopulations in Breast Cancer
Lorenzo F. Sempere;Mette Christensen;Asli Silahtaroglu;Mads Bak.
Cancer Research (2007)
Silencing of microRNA families by seed-targeting tiny LNAs.
Susanna Obad;Camila O dos Santos;Andreas Petri;Markus Heidenblad.
Nature Genetics (2011)
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