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Wigard P. Kloosterman

Wigard P. Kloosterman

D-Index & Metrics

Genetics

D-Index
54
Citations
18011
World Ranking
3619
National Ranking
128

Overview

Wigard P. Kloosterman is affiliated with Utrecht University in the Netherlands. Their research encompasses fields related to biochemistry, genetics, molecular biology, and medicine.

The main areas of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their work spans several subfields such as:

  • Molecular Biology
  • Cancer Research
  • Oncology
  • Immunology
  • Pathology and Forensic Medicine

Kloosterman's research focuses on topics including:

  • Cancer Genomics and Diagnostics
  • Genomics and Phylogenetic Studies
  • Molecular Biology Techniques and Applications
  • RNA modifications and cancer
  • Immunotherapy and Immune Responses
  • Genetic factors in colorectal cancer
  • Ovarian cancer diagnosis and treatment

Recent scientific papers authored or co-authored by Kloosterman include:

  • "Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses," 2020, published in Cell Reports
  • "Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing," 2020, published in Nature Communications
  • "Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns," 2021, published in Nature Genetics
  • "sv-callers: a highly portable parallel workflow for structural variant detection in whole-genome sequence data," 2020, published in PeerJ
  • "A multi-platform reference for somatic structural variation detection," 2022, published in Cell Genomics

The frequent co-authors associated with Kloosterman's publications are:

  • Jeroen de Ridder
  • Edwin Cuppen
  • Ivo Renkens
  • Nicolle Besselink
  • Alessio Marcozzi

Kloosterman has published extensively in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • npj Genomic Medicine
  • Regular and Young Investigator Award Abstracts
  • OPAL (Open@LaTrobe) (La Trobe University)
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • The Diverse Functions of MicroRNAs in Animal Development and Disease

    Wigard P. Kloosterman;Ronald H.A. Plasterk

  • MicroRNA Expression in Zebrafish Embryonic Development

    Erno Wienholds;Wigard P. Kloosterman;Eric Miska;Ezequiel Alvarez-Saavedra

  • In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes

    Wigard P Kloosterman;Erno Wienholds;Ewart de Bruijn;Sakari Kauppinen

  • Whole-genome sequence variation, population structure and demographic history of the Dutch population

    Laurent C. Francioli;Androniki Menelaou;Sara L. Pulit;Freerk van Dijk

  • An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

    Oded Kopper;Chris J de Witte;Kadi Lõhmussaar;Jose Espejo Valle-Inclan

  • Targeted Inhibition of miRNA Maturation with Morpholinos Reveals a Role for miR-375 in Pancreatic Islet Development

    Wigard P Kloosterman;Anne K Lagendijk;René F Ketting;Jon D Moulton

  • From squiggle to basepair: computational approaches for improving nanopore sequencing read accuracy.

    Franka J. Rang;Wigard P. Kloosterman;Jeroen de Ridder

  • MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system

    Marika Kapsimali;Marika Kapsimali;Wigard P Kloosterman;Ewart de Bruijn;Frederic Rosa

  • Mapping and phasing of structural variation in patient genomes using nanopore sequencing

    Mircea Cretu Stancu;Markus J. van Roosmalen;Ivo Renkens;Marleen M. Nieboer

  • Genome-wide patterns and properties of de novo mutations in humans

    Laurent C Francioli;Paz P Polak;Amnon Koren;Androniki Menelaou

  • RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain

    Peter T. Nelson;Don A. Baldwin;Wigard P. Kloosterman;Sakari Kauppinen

  • Substrate requirements for let-7 function in the developing zebrafish embryo.

    Wigard P. Kloosterman;Erno Wienholds;René F. Ketting;Ronald H.A. Plasterk

  • Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline

    Wigard P. Kloosterman;Victor Guryev;Mark van Roosmalen;Karen J. Duran

  • Differences in vertebrate microRNA expression.

    Brandon Ason;Diana K. Darnell;Beate Wittbrodt;Eugene Berezikov

  • The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

    Claire Redin;Claire Redin;Harrison Brand;Harrison Brand;Ryan L Collins;Ryan L Collins;Tammy Kammin

  • The presence of extra chromosomes leads to genomic instability.

    Verena Passerini;Efrat Ozeri-Galai;Mirjam S. de Pagter;Neysan Donnelly

  • miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2

    Luke Pase;Luke Pase;Judith E. Layton;Judith E. Layton;Wigard P. Kloosterman;Duncan Carradice;Duncan Carradice

  • Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness

    Saskia B Wortmann;Frédéric M Vaz;Thatjana Gardeitchik;Lisenka E L M Vissers

  • Constitutional Chromothripsis Rearrangements Involve Clustered Double-Stranded DNA Breaks and Nonhomologous Repair Mechanisms

    Wigard P Kloosterman;Masoumeh Tavakoli-Yaraki;Markus J van Roosmalen;Ellen van Binsbergen

  • Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

    Wigard P Kloosterman;Marlous Hoogstraat;Oscar Paling;Masoumeh Tavakoli-Yaraki

Frequent Co-Authors

Edwin Cuppen
Edwin Cuppen Utrecht University
Ronald H. A. Plasterk
Ronald H. A. Plasterk University of Amsterdam
Michael E. Talkowski
Michael E. Talkowski Harvard University
Victor Guryev
Victor Guryev University Medical Center Groningen
Isaac J. Nijman
Isaac J. Nijman Utrecht University
Björn Menten
Björn Menten Ghent University Hospital
Tobias Marschall
Tobias Marschall Heinrich Heine University Düsseldorf
Emile E. Voest
Emile E. Voest Antoni van Leeuwenhoek Hospital
John W.M. Martens
John W.M. Martens Erasmus University Rotterdam
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen

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