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Biology and Biochemistry

D-Index
84
Citations
30282
World Ranking
3271
National Ranking
1656

Research.com Recognitions

  • 2014 - Fellow of the Royal Society, United Kingdom

Overview

Colin G. Nichols is a researcher affiliated with Washington University in St. Louis in the United States. Their work spans key areas of medicine and biochemistry, genetics, and molecular biology, with significant contributions to the understanding of ion channels, cardiac physiology, and metabolic regulation.

The main fields of study in Nichols' research include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader disciplines, their research focuses on several subfields:

  • Molecular Biology
  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Cellular and Molecular Neuroscience

Significant topics addressed in their work include:

  • Ion channel regulation and function
  • Cardiac Ischemia and Reperfusion
  • Cardiac electrophysiology and arrhythmias
  • Pancreatic function and diabetes
  • Neuroscience and Neuropharmacology Research
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Cardiac Arrest and Resuscitation

Colin G. Nichols has published extensively across various journals, with frequent contributions to the following venues:

  • Biophysical Journal
  • Function
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Diabetes
  • The Journal of General Physiology

Recent papers authored or coauthored by Nichols include:

  • "Coronavirus Proteins as Ion Channels: Current and Potential Research" (2020), Frontiers in Immunology
  • "Kir6.1-dependent KATP channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain-of-function" (2020), The Journal of Physiology
  • "Macrophage secretion of miR-106b-5p causes renin-dependent hypertension" (2020), Nature Communications
  • "Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome" (2020), Frontiers in Pharmacology
  • "KATP channels in lymphatic function" (2022), American Journal of Physiology-Cell Physiology

The research network of Nichols includes several frequent coauthors, highlighting collaborations with:

  • Conor McClenaghan
  • Marı́a S. Remedi
  • N York
  • Sun-Joo Lee
  • Grigory Maksaev

Recognition for Nichols' scientific contributions includes being named a Fellow of the Royal Society, United Kingdom, in 2014.

Best Publications

  • Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.

    Lydia Aguilar-Bryan;Colin G. Nichols;Sérgio W. Wechsler;John P. Clement

  • Regulation of KATP Channel Activity by Diazoxide and MgADP : Distinct Functions of the Two Nucleotide Binding Folds of the Sulfonylurea Receptor

    S.-L. Shyng;T. Ferrigni;C.G. Nichols

  • Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

    K Ho;C G Nichols;W J Lederer;J Lytton

  • Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification

    Anatoli N. Lopatin;Elena N. Makhina;Colin G. Nichols

  • KATP channels as molecular sensors of cellular metabolism.

    Colin G. Nichols

  • INWARD RECTIFIER POTASSIUM CHANNELS

    C. G. Nichols;A. N. Lopatin

  • Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart.

    Kory J. Lavine;Slava Epelman;Keita Uchida;Kassandra J. Weber

  • Adenosine triphosphate-sensitive potassium channels in the cardiovascular system.

    C. G. Nichols;W. J. Lederer

  • Membrane Phospholipid Control of Nucleotide Sensitivity of KATP Channels

    S.-L. Shyng;C. G. Nichols

  • Octameric Stoichiometry of the KATP Channel Complex

    S. L. Shyng;Colin Nichols

  • International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels

    George A. Gutman;K. George Chandy;John P. Adelman;Jayashree Aiyar

  • Adenosine diphosphate as an intracellular regulator of insulin secretion

    Colin Nichols;S. L. Shyng;A. Nestorowicz;B. Glaser

  • Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

    Zhiyu Wang;Nathaniel W. York;Colin G. Nichols;Maria S. Remedi

  • Nucleotide modulation of the activity of rat heart ATP-sensitive K+ channels in isolated membrane patches.

    W J Lederer;C G Nichols

  • International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels

    Yoshihiro Kubo;John P. Adelman;David E. Clapham;Lily Y. Jan

  • Inward Rectifiers in the Heart: An Update on IK1

    A. N. Lopatin;Colin Nichols

  • Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing.

    Emily C McCusker;Claire Bagnéris;Claire E Naylor;Ambrose R Cole

  • Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes

    J.C Koster;B.A Marshall;N Ensor;J.A Corbett

  • ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction.

    C G Nichols;C Ripoll;W J Lederer

  • A Novel Method for Measurement of Submembrane ATP Concentration

    Fiona M. Gribble;Gildas Loussouarn;Stephen J. Tucker;Chao Zhao

Frequent Co-Authors

Richard B. Schuessler
Richard B. Schuessler Washington University in St. Louis
W. J. Lederer
W. J. Lederer University of Maryland, Baltimore
Robert P. Mecham
Robert P. Mecham Washington University in St. Louis
Stephen J. Tucker
Stephen J. Tucker University of Oxford
Susumu Seino
Susumu Seino Kobe University
Taekjip Ha
Taekjip Ha Johns Hopkins University
Bonnie A. Wallace
Bonnie A. Wallace Birkbeck, University of London
David W. Piston
David W. Piston Washington University in St. Louis
Charles A. Stanley
Charles A. Stanley Children's Hospital of Philadelphia

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