World's Best Scientists 2026 revealed!
Susumu Seino

Susumu Seino

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Biology and Biochemistry
Japan
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
112
Citations
46566
World Ranking
897
National Ranking
43

Medicine

D-Index
114
Citations
47065
World Ranking
4746
National Ranking
102

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Susumu Seino was affiliated with Kobe University in Japan and contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spanned several subfields, including surgery, molecular biology, physiology, endocrinology, diabetes and metabolism, as well as pathology and forensic medicine.

The main topics of their work focused on pancreatic function and diabetes, adipose tissue and metabolism, ion channel regulation and function, diabetes treatment and management, metabolism related to diabetes and cancer, cardiac ischemia and reperfusion, and cardiac electrophysiology and arrhythmias.

Susumu Seino published research in various scientific venues, with frequent contributions to the Journal of Diabetes Investigation, where they published three papers. Other publication venues included IUPHAR/BPS Guide to Pharmacology CITE, Molecular Metabolism, Proceedings of the National Academy of Sciences, and Diabetes.

Some of their recent papers included:

  • Increased glycolysis affects β-cell function and identity in aging and diabetes, 2021, Molecular Metabolism
  • The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B 4 axis, 2020, Proceedings of the National Academy of Sciences
  • Glutamate is an essential mediator in glutamine-amplified insulin secretion, 2021, Journal of Diabetes Investigation
  • Dopamine Negatively Regulates Insulin Secretion Through Activation of D1-D2 Receptor Heteromer, 2022, Diabetes
  • Stimulatory effect of imeglimin on incretin secretion, 2023, Journal of Diabetes Investigation

Throughout their career, Susumu Seino collaborated frequently with several researchers, including:

  • Harumi Takahashi
  • Norihide Yokoi
  • Naoya Murao
  • Tomohide Hayami
  • Wataru Ogawa

Best Publications

  • Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.

    Nobuya Inagaki;Tohru Gonoi;John P. Clement;Noriyuki Namba

  • Molecular Biology of Mammalian Glucose Transporters

    Graeme I Bell;Toshiaki Kayano;John B Buse;Charles F Burant

  • A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels

    Nobuya Inagaki;Tohru Gonoi;John P. Clement;Chang Zheng Wang

  • Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

    Yuichiro Yamada;Steven R. Post;Kenneth Wang;Howard S. Tager

  • Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.

    F M Gribble;S J Tucker;S Seino;F M Ashcroft

  • PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis

    Susumu Seino;Tadao Shibasaki

  • ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies

    Susumu Seino

  • Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice

    Takashi Miki;Kazuaki Nagashima;Fumi Tashiro;Kazumi Kotake

  • Physiological and pathophysiological roles of ATP-sensitive K+ channels.

    Susumu Seino;Takashi Miki

  • Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues

    H Fukumoto;T Kayano;J B Buse;Y Edwards

  • ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.

    Takashi Miki;Birgit Liss;Kohtaro Minami;Tetsuya Shiuchi

  • cAMP-GEFII is a direct target of cAMP in regulated exocytosis.

    Nobuaki Ozaki;Tadao Shibasaki;Yasushige Kashima;Takashi Miki

  • International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels

    George A. Gutman;K. George Chandy;John P. Adelman;Jayashree Aiyar

  • Cloning and Functional Characterization of a Novel ATP-sensitive Potassium Channel Ubiquitously Expressed in Rat Tissues, including Pancreatic Islets, Pituitary, Skeletal Muscle, and Heart

    Nobuya Inagaki;Yoshiyuki Tsuura;Noriyuki Namba;Kazuhiro Masuda

  • Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice

    Masashi Suzuki;Norihito Sasaki;Takashi Miki;Naoya Sakamoto

  • Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators

    Hans Georg Joost;Graeme I. Bell;James D. Best;Morris J. Birnbaum

  • Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein.

    Hirofumi Fukumoto;Susumu Seino;Hiroo Imura;Yutaka Seino

  • Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

    Tadao Shibasaki;Harumi Takahashi;Takashi Miki;Yasuhiro Sunaga

  • Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion.

    Yasushige Kashima;Takashi Miki;Tadao Shibasaki;Nobuaki Ozaki

  • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

    Minsuk Kim;Mathew J Platt;Tadao Shibasaki;Susan E Quaggin

Frequent Co-Authors

Nobuya Inagaki
Nobuya Inagaki Kyoto University
Yutaka Seino
Yutaka Seino Kyoto University
Graeme I. Bell
Graeme I. Bell University of Chicago
Toshihiko Iwanaga
Toshihiko Iwanaga Hokkaido University
Hiroo Imura
Hiroo Imura Kyoto University
Andre Terzic
Andre Terzic Mayo Clinic
Wataru Ogawa
Wataru Ogawa Kobe University
Domenico Accili
Domenico Accili Columbia University
Masato Kasuga
Masato Kasuga National Center For Global Health and Medicine
Christian Boitard
Christian Boitard Université Paris Cité

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