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Laurence J. Marton

Laurence J. Marton

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
13978
World Ranking
11306
National Ranking
4896

Overview

Laurence J. Marton is a researcher affiliated with Renovorx in the United States. Their work is primarily situated within the fields of Biochemistry, Genetics, and Molecular Biology, with a focus on subfields including Molecular Biology, Biochemistry, and Pharmacology.

Their recent publications concentrate on polyamine metabolism and its applications, amino acid enzymes and metabolism, and cannabis and cannabinoid research. Notably, Marton has contributed to studies investigating experimental treatments for advanced solid tumors, as reflected in their two recent papers published in 2020.

  • A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma (2020, Cancer Chemotherapy and Pharmacology)
  • A phase I dose-escalation study of the polyamine analog PG-11047 in patients with advanced solid tumors (2020, Cancer Chemotherapy and Pharmacology)

These contributions are published in the journal Cancer Chemotherapy and Pharmacology, which appears as their frequent publication venue. The topics covered emphasize advancements in cancer pharmacology primarily related to polyamine analogs and their therapeutic potential.

Marton has collaborated with several co-authors, indicating interdisciplinary research efforts. Frequent co-authors include Tracy Murray Stewart, Michael L. Fitzgerald, Robert A. Casero, Daniel D. Von Hoff, and Carlos H.R. Becerra.

  • Tracy Murray Stewart
  • Michael L. Fitzgerald
  • Robert A. Casero
  • Daniel D. Von Hoff
  • Carlos H.R. Becerra

The scientist's main areas of research revolve around biochemical pathways involving polyamine metabolism and amino acid enzymes, which are integral to both molecular biology and pharmacology sectors. Additionally, their work includes elements related to cannabis and cannabinoid research, suggesting a diversified research portfolio across contemporary biomedical topics.

Best Publications

  • Polyamines as Targets for Therapeutic Intervention

    L J Marton;A E Pegg

  • Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

    Robert A. Casero;Laurence J. Marton

  • Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

    Tino Schenk;Weihsu Claire Chen;Stefanie Göllner;Louise Howell

  • Subtype and pathway specific responses to anticancer compounds in breast cancer.

    Laura M. Heiser;Anguraj Sadanandam;Wen-Lin Kuo;Stephen C. Benz

  • Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats.

    Gordon D. Lux;Laurence J. Marton;Stephen B. Baylin

  • Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phase liquid chromatography: improved separation systems for polyamines in cerebrospinal fluid, urine and tissue.

    Pokar M. Kabra;Hsian K. Lee;Warren P. Lubich;Laurence J. Marton

  • Implications and concepts of polyamine-nucleic acid interactions.

    Burt G. Feuerstein;Loren D. Williams;Hirak S. Basu;Laurence J. Marton

  • Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes

    Yi Huang;Tracy Murray Stewart;Yu Wu;Stephen B. Baylin

  • Induction of DNA Topoisomerase II-mediated DNA Cleavage by β-Lapachone and Related Naphthoquinones

    Benjamin Frydman;Laurence J. Marton;Jerry S. Sun;Karen Neder

  • Molecular mechanics of the interactions of spermine with DNA: DNA bending as a result of ligand binding

    Burt G. Feuerstein;Nagarajan Pattabiraman;Laurence J Marton

  • Spermine-DNA interactions: a theoretical study.

    Burt G. Feuerstein;Nagarajan Pattabiraman;Laurence J. Marton

  • Effects of variation in the structure of spermine on the association with DNA and the induction of DNA conformational changes.

    H S Basu;H C A Schwietert;B G Feuerstein;L J Marton

  • More Sensitive Automated Detection of Polyamines in Physiological Fluids and Tissue Extracts with o-Phthalaldehyde

    Laurence J. Marton;Patrick L. Y. Lee

  • Polyamines in biology and medicine

    David R. Morris;Laurence J. Marton

  • 4 – Molecular and Cellular Functions of the Polyamines

    Laurence J. Marton;David R. Morris

  • Measurement of Putrescine, Spermidine, and Spermine in Physiological Fluids by Use of an Amino Acid Analyzer

    Laurence J. Marton;Diane H. Russell;Carl C. Levy

  • Stabilization of erythrocyte membranes by polyamines

    Samir K. Ballas;Narla Mohandas;Laurence J. Marton;Stephen B. Shohet

  • Simultaneous measurement of phenobarbital, phenytoin, primidone, ethosuximide, and carbamazepine in serum by high-pressure liquid chromatography.

    P M Kabra;B E Stafford;L J Marton

  • Changes in L-ornithine decarboxylase activity during the cell cycle

    Olle Heby;Joe W. Gray;Patricia A. Lindl;Laurence J. Marton

  • Depletion of 9L rat brain tumor cell polyamine content by treatment with d,l-α-difluoromethylornithine inhibits proliferation and the G1 to S transition

    Jerome Seidenfeld;Joe W. Gray;Laurence J. Marton

Frequent Co-Authors

Robert A. Casero
Robert A. Casero Johns Hopkins University School of Medicine
Burt G. Feuerstein
Burt G. Feuerstein University of California, San Francisco
Patrick M. Woster
Patrick M. Woster Medical University of South Carolina
Charles B. Wilson
Charles B. Wilson University of California, San Francisco
Joe W. Gray
Joe W. Gray Oregon Health & Science University
Victor A. Levin
Victor A. Levin The University of Texas MD Anderson Cancer Center
Diane Haddock Russell
Diane Haddock Russell University of Arizona
Raymond J. Bergeron
Raymond J. Bergeron University of Florida
Peter A. Campochiaro
Peter A. Campochiaro Johns Hopkins University School of Medicine
Anthony E. Pegg
Anthony E. Pegg Pennsylvania State University

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