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Neuroscience

D-Index
38
Citations
6789
World Ranking
8513
National Ranking
463

Overview

Laura Cancedda is affiliated with the Italian Institute of Technology in Italy and has a research focus primarily grounded in biochemistry, genetics, molecular biology, and neuroscience. Their work extends into subfields such as molecular biology, cellular and molecular neuroscience, genetics, public health, environmental and occupational health, and cognitive neuroscience.

The research topics frequently addressed by Laura Cancedda revolve around genetics and neurodevelopmental disorders, neuroscience and neuropharmacology research, ion transport and channel regulation, down syndrome and intellectual disability research, ion channel regulation and function, autism spectrum disorder research, as well as neurogenesis and neuroplasticity mechanisms.

Several notable recent papers authored or co-authored include:

  • "Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome" (2020) published in Neuron
  • "Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders" (2020) published in Chem
  • "Pharmacological tools to target NKCC1 in brain disorders" (2021) published in Trends in Pharmacological Sciences
  • "Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide" (2022) published in Nature Communications
  • "Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome" (2021) published in Molecular Therapy

Frequent co-authors in Laura Cancedda's publications include:

  • Annalisa Savardi
  • Marco De Vivo
  • Andrea Contestabile
  • Marco Borgogno
  • Marina Nanni

Laura Cancedda's research is often published in recurring academic venues such as:

  • Neuroscience Applied
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuron
  • Nature Communications
  • iScience

This profile reflects a research portfolio focused on understanding molecular and cellular mechanisms in neuroscience and genetics, particularly related to neurodevelopmental disorders and ion channel functioning, often using animal models to explore therapeutic interventions.

Best Publications

  • Excitatory GABA action is essential for morphological maturation of cortical neurons in vivo.

    Laura Cancedda;Hubert Fiumelli;Karen Chen;Mu-ming Poo

  • LKB1/STRAD Promotes Axon Initiation During Neuronal Polarization

    Maya Shelly;Laura Cancedda;Sarah Heilshorn;Germán Sumbre

  • Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity

    Alexey Harauzov;Maria Spolidoro;Graziella DiCristo;Roberto De Pasquale

  • Acceleration of Visual System Development by Environmental Enrichment

    Laura Cancedda;Elena Putignano;Alessandro Sale;Alessandro Viegi

  • Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation

    Maya Shelly;Byung Kook Lim;Laura Cancedda;Laura Cancedda;Sarah C. Heilshorn

  • Requirement of ERK activation for visual cortical plasticity.

    Graziella Di Cristo;Nicoletta Berardi;Laura Cancedda;Tommaso Pizzorusso

  • Developmental Downregulation of Histone Posttranslational Modifications Regulates Visual Cortical Plasticity

    Elena Putignano;Giuseppina Lonetti;Laura Cancedda;Gianmichele Ratto

  • Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

    Gabriele Deidda;Martina Parrini;Shovan Naskar;Ignacio F Bozarth

  • Semaphorin3A regulates neuronal polarization by suppressing axon formation and promoting dendrite growth.

    Maya Shelly;Laura Cancedda;Byung Kook Lim;Andrei T. Popescu

  • Modulation of GABAergic transmission by activity via postsynaptic Ca2+-dependent regulation of KCC2 function.

    Hubert Fiumelli;Laura Cancedda;Mu-ming Poo

  • Enriched environment and acceleration of visual system development.

    Alessandro Sale;Elena Putignano;Laura Cancedda;Silvia Landi

  • Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives

    Gabriele Deidda;Ignacio F. Bozarth;Laura Cancedda

  • Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice.

    Valentina Ferretti;Federica Maltese;Gabriella Contarini;Marco Nigro

  • High-performance and site-directed in utero electroporation by a triple-electrode probe

    Marco dal Maschio;Diego Ghezzi;Guillaume Bony;Alessandro Alabastri

  • Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!

    Yehezkel Ben-Ari;Melanie A. Woodin;Evelyne Sernagor;Laura Cancedda

  • GABAergic Control of Neurite Outgrowth and Remodeling During Development and Adult Neurogenesis: General Rules and Differences in Diverse Systems

    Evelyne Sernagor;François Chabrol;Guillaume Bony;Laura Cancedda

  • Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo

    Sebastian Sulis Sato;Pietro Artoni;Silvia Landi;Olga Cozzolino

  • Early depolarizing GABA controls critical-period plasticity in the rat visual cortex

    Gabriele Deidda;Manuela Allegra;Chiara Cerri;Shovan Naskar

  • Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.

    Bruno Pinto;Giovanni Morelli;Mohit Rastogi;Annalisa Savardi

  • The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome.

    Andrea Contestabile;Salvatore Magara;Laura Cancedda

  • Heterozygous Knock-Out Mice for Brain-Derived Neurotrophic Factor Show a Pathway-Specific Impairment of Long-Term Potentiation But Normal Critical Period for Monocular Deprivation

    Alessandro Bartoletti;Laura Cancedda;Susan W. Reid;Lino Tessarollo

  • A cell surface biotinylation assay to reveal membrane associated neuronal cues: Negr1 regulates dendritic arborization.

    Francesca Pischedda;Joanna Szczurkowska;Maria Daniela Cirnaru;Florian Giesert

Frequent Co-Authors

Fabio Benfenati
Fabio Benfenati Italian Institute of Technology
Lamberto Maffei
Lamberto Maffei National Research Council (CNR)
Tommaso Pizzorusso
Tommaso Pizzorusso University of Florence
Mu-ming Poo
Mu-ming Poo Chinese Academy of Sciences
Nicoletta Berardi
Nicoletta Berardi University of Florence
Enzo Di Fabrizio
Enzo Di Fabrizio Polytechnic University of Turin
Alberto Diaspro
Alberto Diaspro Italian Institute of Technology
Francesco Papaleo
Francesco Papaleo Italian Institute of Technology
Evelyne Sernagor
Evelyne Sernagor Newcastle University
Yehezkel Ben-Ari
Yehezkel Ben-Ari Neurochlore (France)

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