Masuo Ohno

Overview

Best Publications

• Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

  Holly Oakley;Sarah L. Cole;Sreemathi Logan;Erika Maus

  4468
  Citations

• BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

  Masuo Ohno;Evgeny A Sametsky;Linda H Younkin;Holly Oakley

  711
  Citations

• Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

  Rui M. Costa;Nikolai B. Federov;Jeff H. Kogan;Geoffrey G. Murphy

  686
  Citations

• α-CaMKII-dependent plasticity in the cortex is required for permanent memory

  Paul W. Frankland;Cara O'Brien;Masuo Ohno;Alfredo Kirkwood

  538
  Citations

• Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

  Dun Sheng Yang;Dun Sheng Yang;Philip Stavrides;Panaiyur S. Mohan;Panaiyur S. Mohan;Susmita Kaushik

  504
  Citations

• Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model.

  Ryoichi Kimura;Masuo Ohno

  373
  Citations

• BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

  Masuo Ohno;Sarah L. Cole;Marina Yasvoina;Jie Zhao

  356
  Citations

• Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

  Masuo Ohno;Lei Chang;Wilbur Tseng;Holly Oakley

  343
  Citations

• 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

  Latha Devi;Masuo Ohno;Masuo Ohno

  301
  Citations

• PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

  Latha Devi;Masuo Ohno;Masuo Ohno

  187
  Citations

• Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease.

  Latha Devi;Melissa J. Alldred;Melissa J. Alldred;Stephen D. Ginsberg;Stephen D. Ginsberg;Masuo Ohno;Masuo Ohno

  185
  Citations

• Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.

  Ryoichi Kimura;Latha Devi;Masuo Ohno

  160
  Citations

• Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease

  Latha Devi;Melissa J Alldred;Melissa J Alldred;Stephen D Ginsberg;Stephen D Ginsberg;Masuo Ohno;Masuo Ohno

  150
  Citations

• Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer’s disease transgenic mice

  Latha Devi;Masuo Ohno;Masuo Ohno

  149
  Citations

• Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD Mice

  Latha Devi;Masuo Ohno

  143
  Citations

• Roles of eIF2α kinases in the pathogenesis of Alzheimer's disease.

  Masuo Ohno;Masuo Ohno

  137
  Citations

• Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

  Dun-Sheng Yang;Dun-Sheng Yang;Philip Stavrides;Panaiyur S. Mohan;Panaiyur S. Mohan;Susmita Kaushik

  124
  Citations

• Increased neuronal excitability, synaptic plasticity and learning in aged Kvβ1.1 knockout mice

  Geoffrey G. Murphy;Nikolai B. Fedorov;K.Peter Giese;Masuo Ohno

  122
  Citations

• Inducible, pharmacogenetic approaches to the study of learning and memory.

  Masuo Ohno;Paul W. Frankland;Adele P. Chen;Rui M. Costa

  121
  Citations

• TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice.

  L Devi;M Ohno

  118
  Citations

• Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats

  Masuo Ohno;Tsuneyuki Yamamoto;Shigenori Watanabe

  116
  Citations