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Neuroscience

D-Index
39
Citations
5750
World Ranking
8351
National Ranking
3568

Overview

Geoffrey G. Murphy is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology. Within these domains, they focus on several subfields, including Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Physiology, and Cognitive Neuroscience.

Their work engages with a range of topics such as Neuroscience and Neuropharmacology Research, Pluripotent Stem Cells Research, Neuroinflammation and Neurodegeneration Mechanisms, Receptor Mechanisms and Signaling, Alzheimer's disease research and treatments, Neurotransmitter Receptor Influence on Behavior, and Neuroscience and Neural Engineering.

Among their recent published papers are:

  • "Deriving early single-rosette brain organoids from human pluripotent stem cells," 2023, Stem Cell Reports
  • "Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity," 2021, Journal of Biological Chemistry
  • "Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity," 2020, Neurobiology of Disease
  • "The role of L-type calcium channels in neuronal excitability and aging," 2020, Neurobiology of Learning and Memory
  • "Multimodal Analysis of STRADA Function in Brain Development," 2020, Frontiers in Cellular Neuroscience

Frequent co-authors in their work include Shannon J. Moore, Rachel Parent, Emily Glass, Eva L. Feldman, and John M. Hayes. This suggests ongoing collaborative efforts in their research endeavors.

Geoffrey G. Murphy has contributed to various publication venues, with repeated publications in bioRxiv (Cold Spring Harbor Laboratory), Alzheimer's & Dementia, Neurobiology of Stress, Stem Cell Reports, and the Journal of Biological Chemistry.

Best Publications

  • Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

    Rui M. Costa;Nikolai B. Federov;Jeff H. Kogan;Geoffrey G. Murphy

  • Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice.

    Stephan G. Anagnostaras;Geoffrey G. Murphy;Susan E. Hamilton;Scott L. Mitchell

  • Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning

    Yijun Cui;Rui M. Costa;Rui M. Costa;Geoffrey G. Murphy;Geoffrey G. Murphy;Ype Elgersma;Ype Elgersma

  • Modulation of Presynaptic Plasticity and Learning by the H-ras/Extracellular Signal-Regulated Kinase/Synapsin I Signaling Pathway

    Steven A. Kushner;Ype Elgersma;Ype Elgersma;Geoffrey G. Murphy;Dick Jaarsma

  • Mediation of Classical Conditioning in Aplysia californica by Long-Term Potentiation of Sensorimotor Synapses

    Geoffrey G. Murphy;David L. Glanzman

  • Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy

    Jacy L. Wagnon;Matthew J. Korn;Rachel Parent;Taylor A. Tarpey

  • Mechanisms and functional significance of aberrant seizure-induced hippocampal neurogenesis.

    Jack M. Parent;Geoffrey G. Murphy

  • Conditional forebrain deletion of the L-type calcium channel CaV1.2 disrupts remote spatial memories in mice

    Jessica A. White;Brandon C. McKinney;Manorama C. John;Patricia A. Powers

  • Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease

    Lisa M. McGinley;Osama N. Kashlan;Elizabeth S. Bruno;Kevin S. Chen

  • The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice.

    Brandon C. McKinney;Geoffrey G. Murphy

  • Increased neuronal excitability, synaptic plasticity and learning in aged Kvβ1.1 knockout mice

    Geoffrey G. Murphy;Nikolai B. Fedorov;K.Peter Giese;Masuo Ohno

  • Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice

    Benjamin H. Singer;Amy E. Gamelli;Cynthia L. Fuller;Stephanie J. Temme

  • Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation

    Benjamin H. Singer;Michael W. Newstead;Xianying Zeng;Christopher L. Cooke

  • Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation.

    Robert A. Rose;Michael Sellan;Jeremy A. Simpson;Farzad Izaddoustdar

  • Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice

    Veronica T. Cheli;Diara A. Santiago González;Tenzing Namgyal Lama;Vilma Spreuer

  • Enhancement of sensorimotor connections by conditioning-related stimulation in Aplysia depends upon postsynaptic Ca2+

    Geoffrey G. Murphy;David L. Glanzman

  • Cellular analog of differential classical conditioning in Aplysia: disruption by the NMDA receptor antagonist DL-2-amino-5-phosphonovalerate.

    Geoffrey G. Murphy;David L. Glanzman

  • L‐type voltage‐operated calcium channels contribute to astrocyte activation In vitro

    Veronica T. Cheli;Diara A. Santiago González;Jessica Smith;Vilma Spreuer

  • Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor

    Tommaso Patriarchi;Hai Qian;Valentina Di Biase;Zulfiquar A. Malik;Zulfiquar A. Malik

  • Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6).

    Brandon C. McKinney;Clement Y. Chow;Miriam H. Meisler;Geoffrey G. Murphy

  • Critical roles of αII spectrin in brain development and epileptic encephalopathy.

    Yu Wang;Tuo Ji;Andrew D. Nelson;Katarzyna Glanowska

  • Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of CaV1.3 knockout mice

    Brandon C. McKinney;Wilson Sze;Benjamin Lee;Geoffrey G. Murphy;Geoffrey G. Murphy

  • Deletion of the Mouse Homolog of KCNAB2, a Gene Linked to Monosomy 1p36, Results in Associative Memory Impairments and Amygdala Hyperexcitability

    John J. Perkowski;Geoffrey G. Murphy

Frequent Co-Authors

Jack M. Parent
Jack M. Parent University of Michigan–Ann Arbor
Alcino J. Silva
Alcino J. Silva University of California, Los Angeles
Ype Elgersma
Ype Elgersma Erasmus University Rotterdam
Rui M. Costa
Rui M. Costa Columbia University
Michael A. Sutton
Michael A. Sutton University of Michigan–Ann Arbor
David L. Glanzman
David L. Glanzman University of California, Los Angeles
Eva L. Feldman
Eva L. Feldman University of Michigan–Ann Arbor
Huda Akil
Huda Akil University of Michigan–Ann Arbor
Miriam H. Meisler
Miriam H. Meisler University of Michigan–Ann Arbor
Melvin G. McInnis
Melvin G. McInnis University of Michigan–Ann Arbor

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