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D-Index & Metrics

Biology and Biochemistry

D-Index
99
Citations
37244
World Ranking
1584
National Ranking
888

Research.com Recognitions

  • 2020 - Member of the National Academy of Medicine (NAM)
  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Henry L. Paulson is a researcher affiliated with the University of Michigan-Ann Arbor in the United States. Their work spans multiple disciplines within medicine and molecular biology, emphasizing genetic neurodegenerative diseases and neurological disorders.

The primary fields of study for Paulson include Medicine and Biochemistry, Genetics and Molecular Biology. Their research touches several subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Physiology, and Psychiatry and Mental Health.

The scientist's main research topics include:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Alzheimer's Disease Research and Treatments
  • Dementia and Cognitive Impairment Research
  • Ubiquitin and Proteasome Pathways
  • Parkinson's Disease Mechanisms and Treatments
  • Neurological Disorders and Treatments

Frequent co-authors collaborating with Paulson are:

  • Tetsuo Ashizawa
  • Lisa M. Sharkey
  • Vikram G. Shakkottai
  • Khalaf Bushara
  • Jeremy D. Schmahmann

Paulson has published extensively in several venues. The most frequent publication venues are:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurology
  • The Cerebellum
  • Scientific Reports

Notable recent papers include:

  • Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3, 2020, Science Translational Medicine
  • GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin, 2022, Journal of Biological Chemistry
  • Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain, 2020, JCI Insight
  • Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3, 2022, Annals of Neurology
  • Lessons Learned from Approval of Aducanumab for Alzheimer's Disease, 2024, Annual Review of Medicine

Paulson has received recognition in the form of awards, including being named a Member of the National Academy of Medicine in 2020 and a Fellow of the American Association for the Advancement of Science in 2016.

Best Publications

  • siRNA-mediated gene silencing in vitro and in vivo

    Haibin Xia;Qinwen Mao;Henry L Paulson;Beverly L Davidson

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

    John M. Warrick;H. Y.Edwin Chan;Gladys L. Gray-Board;Yaohui Chai

  • Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3

    H.L Paulson;M.K Perez;Y Trottier;J.Q Trojanowski

  • RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.

    Scott Q. Harper;Patrick D. Staber;Xiaohua He;Steven L. Eliason

  • RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia

    Haibin Xia;Qinwen Mao;Steven L Eliason;Scott Q Harper

  • Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila

    John M Warrick;Henry L Paulson;Gladys L Gray-Board;Quang T Bui

  • CREB-binding protein sequestration by expanded polyglutamine

    Alexander McCampbell;J. Paul Taylor;Addis A. Taye;Jon Robitschek

  • Allele-specific silencing of dominant disease genes

    Victor M. Miller;Haibin Xia;Ginger L. Marrs;Cynthia M. Gouvion

  • Analysis of the Role of Heat Shock Protein (Hsp) Molecular Chaperones in Polyglutamine Disease

    Yaohui Chai;Stacia L. Koppenhafer;Nancy M. Bonini;Henry L. Paulson

  • CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome

    Peter K. Todd;Seok Yoon Oh;Amy Krans;Fang He

  • Evidence for Proteasome Involvement in Polyglutamine Disease: Localization to Nuclear Inclusions in SCA3/MJD and Suppression of Polyglutamine Aggregation in vitro

    Yaohui Chai;Stacia L. Koppenhafer;Sarah J. Shoesmith;Matthew K. Perez

  • SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

    Maged M. Harraz;Jennifer J. Marden;Weihong Zhou;Yulong Zhang

  • Trinucleotide repeats in neurogenetic disorders

    H. L. Paulson;K. H. Fischbeck

  • Repeat expansion diseases.

    Henry Paulson

  • Polyglutamine neurodegeneration: protein misfolding revisited.

    Aislinn J. Williams;Henry L. Paulson

  • Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila

    H.Y. Edwin Chan;John M. Warrick;Gladys L. Gray-Board;Henry L. Paulson

  • Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7.

    Udo Rüb;Ludger Schöls;Henry Paulson;Georg Auburger

  • Recruitment and the Role of Nuclear Localization in Polyglutamine-mediated Aggregation

    Matthew K. Perez;Henry L. Paulson;Sagun J. Pendse;Sarah J. Saionz

  • Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.

    John M. Warrick;John M. Warrick;Lance M. Morabito;Lance M. Morabito;Julide Bilen;Beth Gordesky-Gold

Frequent Co-Authors

Vikram G. Shakkottai
Vikram G. Shakkottai The University of Texas Southwestern Medical Center
Beverly L. Davidson
Beverly L. Davidson Children's Hospital of Philadelphia
Stefan M. Pulst
Stefan M. Pulst University of Utah
Tetsuo Ashizawa
Tetsuo Ashizawa Houston Methodist
Christopher M. Gomez
Christopher M. Gomez University of Chicago
Jeremy D. Schmahmann
Jeremy D. Schmahmann Harvard Medical School
Susan Perlman
Susan Perlman University of California, Los Angeles
Sheng-Han Kuo
Sheng-Han Kuo Columbia University Medical Center
Roger L. Albin
Roger L. Albin University of Michigan–Ann Arbor
Udo Rüb
Udo Rüb Goethe University Frankfurt

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