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Neuroscience

D-Index
38
Citations
5866
World Ranking
8555
National Ranking
3640

Overview

Vikram G. Shakkottai is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research spans multiple areas within the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine, with notable contributions to subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Genetics, and Cell Biology.

The scientist's work addresses a range of topics including:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Neurological disorders and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • RNA Research and Splicing
  • Ion channel regulation and function
  • Amyotrophic Lateral Sclerosis Research

Vikram G. Shakkottai's publication record includes recent papers that cover important advances in neurodegenerative diseases and neurological model systems. Some of the recent studies are:

  • "Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture," published in 2021 in Nature Genetics
  • "Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups," published in 2021 in Brain
  • "Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3," published in 2020 in Science Translational Medicine
  • "Deriving early single-rosette brain organoids from human pluripotent stem cells," published in 2023 in Stem Cell Reports
  • "A Chlorzoxazone-Baclofen Combination Improves Cerebellar Impairment in Spinocerebellar Ataxia Type 1," published in 2020 in Movement Disorders

Frequent collaborators include Henry L. Paulson, Liana S. Rosenthal, Stefan M. Pulst, Tetsuo Ashizawa, and Khalaf Bushara.

Vikram G. Shakkottai has published extensively in several scientific venues. The most frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Cerebellum
  • Neurology
  • Movement Disorders
  • Brain

The research contributions of Shakkottai focus primarily on complex genetic neurodegenerative diseases, combining molecular biology and neuroscience approaches. Their work includes investigations into mitochondrial dysfunction and neurological treatment strategies relevant for disorders such as Parkinson's disease, spinocerebellar ataxia, and dementia with Lewy bodies.

Best Publications

  • Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

    Ruth Chia;Marya S. Sabir;Sara Bandres-Ciga

  • Polyglutamine spinocerebellar ataxias — from genes to potential treatments

    Henry L. Paulson;Vikram G. Shakkottai;H. Brent Clark;Harry T. Orr

  • Polyglutamine Repeats in Neurodegenerative Diseases.

    Andrew P. Lieberman;Vikram G. Shakkottai;Roger L. Albin

  • Modulators of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels and their Therapeutic Indications

    Heike Wulff;Aaron Kolski-Andreaco;Ananthakrishnan Sankaranarayanan;Jean Marc Sabatier

  • Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3

    Vikram G. Shakkottai;Maria do Carmo Costa;James M. Dell'Orco;Ananthakrishnan Sankaranarayanan

  • Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia

    Vikram G. Shakkottai;Amit Batla;Kailash Bhatia;William T. Dauer

  • Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

    Eunju Seong;Ryan Insolera;Marija Dulovic;Erik Jan Kamsteeg

  • Mutations in KCND3 cause spinocerebellar ataxia type 22

    Yi Chung Lee;Alexandra Durr;Karen Majczenko;Yen Hua Huang

  • Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration

    Matthew J. Elrick;Chris D. Pacheco;Ting Yu;Nahid Dadgar

  • Clinical characteristics of patients with spinocerebellar ataxias 1, 2, 3 and 6 in the US; A prospective observational study

    Tetsuo Ashizawa;Karla P Figueroa;Susan L Perlman;Christopher M Gomez

  • FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons.

    Vikram G. Shakkottai;Maolei Xiao;Lin Xu;Michael Wong

  • SKCa Channels Mediate the Medium But Not the Slow Calcium-Activated Afterhyperpolarization in Cortical Neurons

    Claudio Villalobos;Vikram G. Shakkottai;K. George Chandy;Sharon K. Michelhaugh

  • Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice.

    Hayley S. McLoughlin;Lauren R. Moore;Ravi Chopra;Robert Komlo

  • Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.

    Vikram G. Shakkottai;Imed Regaya;Heike Wulff;Ziad Fajloun

  • Clinical Neurogenetics: Autosomal Dominant Spinocerebellar Ataxia

    Vikram G. Shakkottai;Brent L. Fogel

  • Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia

    Vikram G. Shakkottai;Chin Hua Chou;Salvatore Oddo;Claudia A. Sailer

  • Depression and clinical progression in spinocerebellar ataxias

    Raymond Y. Lo;Karla P. Figueroa;Stefan M. Pulst;Susan Perlman

  • Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.

    James M. Dell’Orco;Aaron H. Wasserman;Ravi Chopra;Melissa A.C. Ingram

  • Toward RNAi therapy for the polyglutamine disease Machado-Joseph disease.

    Maria do Carmo Costa;Katiuska Luna-Cancalon;Svetlana Fischer;Naila S Ashraf

  • Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia.

    H Tomita;V G Shakkottai;G A Gutman;G Sun

  • Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration

    Ting Yu;Vikram G. Shakkottai;Chan Chung;Andrew P. Lieberman

  • Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7

    Colleen A. Stoyas;David D. Bushart;Pawel M. Switonski;Pawel M. Switonski;Jacqueline M. Ward

Frequent Co-Authors

Stefan M. Pulst
Stefan M. Pulst University of Utah
Jeremy D. Schmahmann
Jeremy D. Schmahmann Harvard Medical School
Tetsuo Ashizawa
Tetsuo Ashizawa Houston Methodist
Sheng-Han Kuo
Sheng-Han Kuo Columbia University Medical Center
Margit Burmeister
Margit Burmeister University of Michigan–Ann Arbor
Harry T. Orr
Harry T. Orr University of Minnesota
Geoffrey G. Murphy
Geoffrey G. Murphy University of Michigan–Ann Arbor
Thomas S. Otis
Thomas S. Otis University College London
Jun Li
Jun Li University of Oklahoma Health Sciences Center
Alexis Brice
Alexis Brice Institut du Cerveau

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