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Neuroscience

D-Index
49
Citations
10390
World Ranking
5927
National Ranking
484

Overview

Thomas S. Otis is affiliated with University College London in the United Kingdom. Their research spans several fields, including Biochemistry, Genetics and Molecular Biology, as well as Medicine. The subfields of study especially relevant to their work include Genetics, Molecular Biology, and Cardiology and Cardiovascular Medicine.

The scientist's research primarily focuses on virus-based gene therapy, CRISPR and genetic engineering, and viral infections and immunology. These topics appear consistently across their publications, highlighting a concentration on advanced molecular techniques and immunological responses related to viruses and genetic therapeutics.

Otis has contributed to research published in the Annual Review of Neuroscience, among other venues. Their recent paper is titled "Adeno-Associated Virus Toolkit to Target Diverse Brain Cells," published in 2022 in the Annual Review of Neuroscience.

  • Adeno-Associated Virus Toolkit to Target Diverse Brain Cells, 2022, Annual Review of Neuroscience

Frequent co-authors accompanying Otis in their work include Rosemary C. Challis, Sripriya Ravindra Kumar, Xinhong Chen, David Goertsen, and Gerard Michael Coughlin.

  • Rosemary C. Challis
  • Sripriya Ravindra Kumar
  • Xinhong Chen
  • David Goertsen
  • Gerard Michael Coughlin

Otis's interdisciplinary research integrates areas of molecular biology and genetics with clinical insights from cardiology and immunology, reflecting in the diversity of topics and subfields studied. Their work contributes to understanding viral mechanisms and the development of gene therapy technologies targeting brain cells and other molecular pathways.

Best Publications

  • Bridging the cleft at GABA synapses in the brain

    I. Mody;Y. De Koninck;T.S. Otis;I. Soltesz

  • Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

    Dhruv Sareen;Jacqueline G. O’Rourke;Pratap Meera;A. K. M. G. Muhammad

  • Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model.

    Eberhard H. Buhl;Thomas S. Otis;Istvan Mody

  • Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings

    K. J. Staley;T. S. Otis;I. Mody

  • Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity.

    H Jacob Hanchar;Paul D Dodson;Richard W Olsen;Thomas S Otis

  • Antisense oligonucleotide therapy for spinocerebellar ataxia type 2

    Daniel R. Scoles;Pratap Meera;Matthew D. Schneider;Sharan Paul

  • Progress in Understanding and Treating SCN2A-Mediated Disorders

    Stephan J. Sanders;Arthur J. Campbell;Jeffrey R. Cottrell;Rikke S. Moller

  • Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons.

    T.S. Otis;I. Mody

  • Holographic photolysis of caged neurotransmitters

    Christoph Lutz;Thomas S Otis;Thomas S Otis;Vincent DeSars;Serge Charpak

  • Photochemical control of endogenous ion channels and cellular excitability

    Doris L Fortin;Matthew R Banghart;Timothy W Dunn;Katharine Borges

  • Characterization of synaptically elicited GABAB responses using patch-clamp recordings in rat hippocampal slices.

    T S Otis;Y De Koninck;I Mody

  • Lasting potentiation of inhibition is associated with an increased number of gamma-aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents

    T S Otis;Y De Koninck;I Mody

  • Delayed clearance of transmitter and the role of glutamate transporters at synapses with multiple release sites

    Thomas S. Otis;Yuh Cherng Wu;Laurence O. Trussell

  • Neuronal Glutamate Transporters Control Activation of Postsynaptic Metabotropic Glutamate Receptors and Influence Cerebellar Long-Term Depression

    Gabor Brasnjo;Thomas S. Otis

  • Direct Measurement of AMPA Receptor Desensitization Induced by Glutamatergic Synaptic Transmission

    Thomas Otis;Su Zhang;Laurence O. Trussell

  • Anion Currents and Predicted Glutamate Flux through a Neuronal Glutamate Transporter

    Thomas S. Otis;Craig E. Jahr

  • Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release.

    Thomas S. Otis;Kevin J. Staley;Istvan Mody

  • Postsynaptic Glutamate Transport at the Climbing Fiber-Purkinje Cell Synapse

    Thomas S. Otis;Michael P. Kavanaugh;Craig E. Jahr

  • Differential activation of GABAA and GABAB receptors by spontaneously released transmitter.

    T. S. Otis;I. Mody

  • Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2

    Stephen T. Hansen;Pratap Meera;Thomas S. Otis;Stefan M. Pulst

  • Isolation of Current Components and Partial Reaction Cycles in the Glial Glutamate Transporter EAAT2

    Thomas S. Otis;Michael P. Kavanaugh

  • Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABAA receptors

    Pratap Meera;Martin Wallner;Thomas S. Otis

  • Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition

    Vijayalakshmi Santhakumar;Martin Wallner;Thomas S. Otis

Frequent Co-Authors

Stefan M. Pulst
Stefan M. Pulst University of Utah
Richard W. Olsen
Richard W. Olsen University of California, Los Angeles
Laurence O. Trussell
Laurence O. Trussell Oregon Health & Science University
Kevin J. Staley
Kevin J. Staley Harvard University
Carolyn R. Houser
Carolyn R. Houser University of California, Los Angeles
Istvan Mody
Istvan Mody University of California, Los Angeles
Georg Köhr
Georg Köhr Heidelberg University
Indira M. Raman
Indira M. Raman Northwestern University
Chris I. De Zeeuw
Chris I. De Zeeuw Erasmus University Rotterdam
Craig E. Jahr
Craig E. Jahr Oregon Health & Science University

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