World's Best Scientists 2026 revealed!
Leonard Petrucelli

Leonard Petrucelli

D-Index & Metrics

Neuroscience

D-Index
108
Citations
39765
World Ranking
592
National Ranking
334

Medicine

D-Index
108
Citations
39800
World Ranking
6042
National Ranking
3231

Overview

Leonard Petrucelli is affiliated with the Mayo Clinic in the United States. Their research spans primarily in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Within these areas, their work focuses on subfields such as Neurology, Molecular Biology, Genetics, Physiology, and Cellular and Molecular Neuroscience.

The scientist has contributed to several main research topics, including:

  • Amyotrophic Lateral Sclerosis Research
  • Neurogenetic and Muscular Disorders Research
  • Alzheimer's Disease Research and Treatments
  • RNA Research and Splicing
  • Parkinson's Disease Mechanisms and Treatments
  • Genetic Neurodegenerative Diseases
  • Prion Diseases and Protein Misfolding

Petrucelli has been a frequent contributor to multiple scientific journals. The venues with the highest number of their publications include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • Molecular Neurodegeneration
  • Science Translational Medicine
  • Neurology

Some of their recent papers are as follows:

  • "TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A," 2022, Nature
  • "Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains," 2020, Cell
  • "Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia," 2020, Journal of Clinical Investigation
  • "Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72," 2020, Nature Neuroscience
  • "Cellular and pathological heterogeneity of primary tauopathies," 2021, Molecular Neurodegeneration

The researcher frequently collaborates with several coauthors, including:

  • Dennis W. Dickson
  • Mercedes Prudencio
  • Tania F. Gendron
  • Bradley F. Boeve
  • Karen Jansen-West

Best Publications

  • Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

    Peter E.A. Ash;Kevin F. Bieniek;Tania F. Gendron;Thomas Caulfield

  • GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

    Brian D. Freibaum;Yubing Lu;Rodrigo Lopez-Gonzalez;Nam Chul Kim

  • CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

    Leonard Petrucelli;Dennis Dickson;Kathryn Kehoe;Julie Taylor

  • The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

    Chad A. Dickey;Chad A. Dickey;Adeela Kamal;Karen Lundgren;Natalia Klosak

  • Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

    Dhruv Sareen;Jacqueline G. O’Rourke;Pratap Meera;A. K. M. G. Muhammad

  • Structural determinants of the cellular localization and shuttling of TDP-43

    Youhna M. Ayala;Paola Zago;Andrea D'Ambrogio;Ya Fei Xu

  • Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.

    Leonard Petrucelli;Casey O'Farrell;Paul J. Lockhart;Melisa Baptista

  • Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

    Liqun Liu-Yesucevitz;Aylin Bilgutay;Yong Jie Zhang;Tara Vanderwyde

  • Aberrant Cleavage of TDP-43 Enhances Aggregation and Cellular Toxicity

    Yong Jie Zhang;Ya Fei Xu;Casey Cook;Tania F. Gendron

  • The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity

    Natalie Ostrerova-Golts;Leonard Petrucelli;John Hardy;John M. Lee

  • Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

    Ya Fei Xu;Tania F. Gendron;Yong Jie Zhang;Wen Lang Lin

  • ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

    Radu Stoica;Kurt J. De Vos;Kurt J. De Vos;Sébastien Paillusson;Sarah Mueller

  • Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

    Tania F Gendron;Kevin F. Bieniek;Yong-Jie Zhang;Karen Jansen-West

  • Lewy bodies and parkinsonism in families with parkin mutations.

    M Farrer;P Chan;R Chen;L Tan

  • The role of tau in neurodegeneration

    Tania F Gendron;Leonard Petrucelli

  • TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

    Ching Chieh Chou;Yi Zhang;Yi Zhang;Mfon E. Umoh;Spencer W. Vaughan

  • Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

    Jie Jiang;Jie Jiang;Qiang Zhu;Tania F. Gendron;Shahram Saberi

  • Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.

    Nicola J. Rutherford;Yong-Jie Zhang;Matt Baker;Jennifer M Gass

  • Converging pathways in neurodegeneration, from genetics to mechanisms.

    Li Gan;Li Gan;Mark R. Cookson;Leonard Petrucelli;Albert R. La Spada

  • An autoradiographic evaluation of AV-1451 Tau PET in dementia.

    Val J. Lowe;Geoffry Curran;Ping Fang;Amanda M. Liesinger

Frequent Co-Authors

Tania F. Gendron
Tania F. Gendron Mayo Clinic
Rosa Rademakers
Rosa Rademakers University of Antwerp
Bradley F. Boeve
Bradley F. Boeve Mayo Clinic
David S. Knopman
David S. Knopman Mayo Clinic
Keith A. Josephs
Keith A. Josephs Mayo Clinic
Ronald C. Petersen
Ronald C. Petersen University of Pennsylvania
Joseph E. Parisi
Joseph E. Parisi Mayo Clinic

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