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Biology and Biochemistry

D-Index
65
Citations
19649
World Ranking
9015
National Ranking
655

Overview

Dieter Edbauer is affiliated with the German Center for Neurodegenerative Diseases in Germany. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with specialized subfields including Neurology, Molecular Biology, Genetics, Physiology, and Epidemiology.

The main focus of their scientific work involves topics related to neurodegenerative diseases, notably Amyotrophic Lateral Sclerosis (ALS) Research, Neurogenetic and Muscular Disorders Research, Parkinson's Disease Mechanisms and Treatments, Prion Diseases and Protein Misfolding, Alzheimer's Disease Research and Treatments, RNA Research and Splicing, as well as Neurological Diseases and Metabolism.

Key recent publications by Dieter Edbauer include:

  • Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation, 2022, The EMBO Journal
  • Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions, 2020, Cell Reports
  • Loss of TMEM 106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice, 2020, EMBO Reports
  • Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS / FTD, 2020, The EMBO Journal
  • Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS, 2020, Acta Neuropathologica

Their frequent coauthors include:

  • Christian Haass
  • Henrick Riemenschneider
  • Qihui Zhou
  • Dorothee Dormann
  • Daniel Farny

Common publication venues for Edbauer's work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The EMBO Journal
  • EMBO Reports
  • Nature Communications
  • Cell Reports

Best Publications

  • The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

    Kohji Mori;Shih-Ming Weng;Thomas Arzberger;Stephanie May

  • Reconstitution of gamma-secretase activity.

    Dieter Edbauer;Edith Winkler;Joerg T. Regula;Brigitte Pesold

  • ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

    Dorothee Dormann;Dorothee Dormann;Ramona Rodde;Ramona Rodde;Dieter Edbauer;Eva Bentmann;Eva Bentmann

  • Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

    Dieter Edbauer;Joel R. Neilson;Kelly A. Foster;Chi-Fong Wang

  • Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

    Jie Jiang;Jie Jiang;Qiang Zhu;Tania F. Gendron;Shahram Saberi

  • Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

    Samira Parhizkar;Thomas Arzberger;Matthias Brendel;Gernot Kleinberger

  • Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

    Kohji Mori;Thomas Arzberger;Thomas Arzberger;Friedrich A. Grässer;Ilse Gijselinck

  • C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

    Jeannie Chew;Tania F. Gendron;Mercedes Prudencio;Hiroki Sasaguri

  • PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin

    Harald Steiner;Edith Winkler;Dieter Edbauer;Stefan Prokop

  • MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.

    Julia Banzhaf-Strathmann;Eva Benito;Stephanie May;Thomas Arzberger

  • hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

    Kohji Mori;Sven Lammich;Ian R. A. Mackenzie;Ignasi Forné

  • microRNA‐34c is a novel target to treat dementias

    Athanasios Zovoilis;Hope Y Agbemenyah;Roberto C Agis-Balboa;Roman M Stilling

  • Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

    Sven Lammich;Masayasu Okochi;Masatoshi Takeda;Christoph Kaether

  • MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function

    Brooke H. Miller;Zane Zeier;Li Xi;Thomas A. Lanz

  • In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.

    Qiang Guo;Carina Lehmer;Antonio Martínez-Sánchez;Till Rudack;Till Rudack

  • Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

    Ian R. Mackenzie;Thomas Arzberger;Thomas Arzberger;Elisabeth Kremmer;Elisabeth Kremmer;Dirk Troost

  • Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation

    Dieter Edbauer;Edith Winkler;Christian Haass;Harald Steiner

  • C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration

    Stephanie May;Daniel Hornburg;Martin H. Schludi;Thomas Arzberger;Thomas Arzberger

  • Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.

    Johnathan Cooper-Knock;Matthew J. Walsh;Adrian Higginbottom;J. Robin Highley

  • Role of septin cytoskeleton in spine morphogenesis and dendrite development in neurons

    Tomoko Tada;Alyson Simonetta;Matthew Batterton;Makoto Kinoshita

Frequent Co-Authors

Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Harald Steiner
Harald Steiner Ludwig-Maximilians-Universität München
Manuela Neumann
Manuela Neumann University of Tübingen
Thomas Klopstock
Thomas Klopstock Ludwig-Maximilians-Universität München
Anja Capell
Anja Capell Ludwig-Maximilians-Universität München
Ian R. Mackenzie
Ian R. Mackenzie University of British Columbia
Elisabeth Kremmer
Elisabeth Kremmer Max Planck Society
Marc Cruts
Marc Cruts University of Antwerp
Christine Van Broeckhoven
Christine Van Broeckhoven University of Antwerp

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