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Biology and Biochemistry

D-Index
70
Citations
13632
World Ranking
7176
National Ranking
131

Overview

Pascal Hols is affiliated with the Université Catholique de Louvain in Belgium and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Food Science, Genetics, Microbiology, and Public Health, Environmental and Occupational Health.

Their research covers topics including:

  • Probiotics and Fermented Foods
  • Bacterial Genetics and Biotechnology
  • Biochemical and Structural Characterization
  • Bacterial Infections and Vaccines
  • RNA and protein synthesis mechanisms
  • Bacterial biofilms and quorum sensing
  • Streptococcal Infections and Treatments

Pascal Hols has published in various scientific venues, among which the most frequent include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Communications Biology
  • PLoS Genetics
  • Scientific Reports
  • Proceedings of the National Academy of Sciences

Recent notable papers include:

  • Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases (2020, Scientific Reports)
  • Molecular dissection of pheromone selectivity in the competence signaling system ComRS of streptococci (2020, Proceedings of the National Academy of Sciences)
  • The CovRS Environmental Sensor Directly Controls the ComRS Signaling System To Orchestrate Competence Bimodality in Salivarius Streptococci (2022, mBio)
  • Expanding natural transformation to improve beneficial lactic acid bacteria (2022, FEMS Microbiology Reviews)
  • A Genome-Wide CRISPR Interference Screen Reveals an StkP-Mediated Connection between Cell Wall Integrity and Competence in Streptococcus salivarius (2022, mSystems)

Frequent collaborators of Pascal Hols include:

  • Johann Mignolet
  • Adrien Knoops
  • Patrice Soumillion
  • Laura Ledesma-García
  • Philippe Gabant

The body of work reflects a strong emphasis on bacterial genetics and the molecular mechanisms underlying bacterial competence, signaling, and transformation. The research also intersects with food science, particularly in studying lactic acid bacteria and probiotic organisms.

Best Publications

  • Lactobacillus plantarum Promotes Drosophila Systemic Growth by Modulating Hormonal Signals through TOR-Dependent Nutrient Sensing

    Gilles Storelli;Arnaud Defaye;Berra Erkosar;Pascal Hols

  • Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus

    Alexander Bolotin;Benoît Quinquis;Pierre Renault;Alexei Sorokin

  • Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids.

    Corinne Grangette;Sophie Nutten;Sophie Nutten;Emmanuelle Palumbo;Siegfried Morath

  • New insights in the molecular biology and physiology of Streptococcus thermophilus revealed by comparative genomics

    Pascal Hols;Frédéric Hancy;Laetitia Fontaine;Benoît Grossiord

  • The extracellular biology of the lactobacilli

    Michiel Kleerebezem;Pascal Hols;Elvis Bernard;Thomas Rolain

  • The biosynthesis and functionality of the cell-wall of lactic acid bacteria

    Jean Delcour;Thierry Ferain;Marie Deghorain;Emmanuelle Palumbo

  • Discovering lactic acid bacteria by genomics

    Todd Klaenhammer;Eric Altermann;Fabrizio Arigoni;Alexander Bolotin

  • Conversion of Lactococcus lactis from homolactic to homoalanine fermentation through metabolic engineering

    Pascal Hols;M Kleerebezem;André Schanck;T. Ferain

  • A novel pheromone quorum-sensing system controls the development of natural competence in Streptococcus thermophilus and Streptococcus salivarius

    Laetitia Fontaine;Céline Boutry;Marie Henry de Frahan;Brigitte Delplace

  • Lactococcus lactis as a cell factory for high-level diacetyl production.

    J Hugenholtz;M Kleerebezem;M Starrenburg;Jean Delcour

  • Adaptation of the nisin-controlled expression system in Lactobacillus plantarum: a tool to study in vivo biological effects

    Sonia Pavan;Pascal Hols;Jean Delcour;Marie-Claude Geoffroy

  • Detection, localization, and conformational analysis of single polysaccharide molecules on live bacteria.

    Gregory Francius;Sarah Lebeer;David Alsteens;Linda Wildling

  • Cell Surface of Lactococcus lactis Is Covered by a Protective Polysaccharide Pellicle

    Marie-Pierre Chapot-Chartier;Evgeny Vinogradov;Irina Sadovskaya;Irina Sadovskaya;Guillaume Andre

  • Single-Cell Force Spectroscopy of Probiotic Bacteria

    Audrey Beaussart;Sofiane El-Kirat-Chatel;Philippe Herman;David Alsteens

  • Metabolic engineering of lactic acid bacteria for the production of nutraceuticals

    Jeroen Hugenholtz;Wilbert Sybesma;Masja Nierop Groot;Wouter Wisselink

  • Single-molecule force spectroscopy and imaging of the vancomycin/D-Ala-D-Ala interaction.

    Yann Gilbert;Marie Deghorain;Ling Wang;Binghe B. Xu

  • Genome-Scale Model of Streptococcus thermophilus LMG18311 for Metabolic Comparison of Lactic Acid Bacteria

    Margreet I. Pastink;Bas Teusink;Pascal Hols;Sanne Visser

  • Imaging the nanoscale organization of peptidoglycan in living Lactococcus lactis cells

    Guillaume Andre;Saulius Kulakauskas;Marie-Pierre Chapot-Chartier;Benjamine Navet

  • Use of the alr Gene as a Food-Grade Selection Marker in Lactic Acid Bacteria

    Peter A. Bron;Marcos G. Benchimol;Jolanda Lambert;Emmanuelle Palumbo

  • Characterization of O-Acetylation of N-Acetylglucosamine A NOVEL STRUCTURAL VARIATION OF BACTERIAL PEPTIDOGLYCAN

    Elvis Bernard;Thomas Rolain;Pascal Courtin;Pascal Courtin;Alain Guillot;Alain Guillot

Frequent Co-Authors

Michiel Kleerebezem
Michiel Kleerebezem Wageningen University & Research
Yves F. Dufrêne
Yves F. Dufrêne Université Catholique de Louvain
Annick Mercenier
Annick Mercenier NutriLeads (Netherlands)
Jeroen Hugenholtz
Jeroen Hugenholtz University of Groningen
Oscar P. Kuipers
Oscar P. Kuipers University of Groningen
Willem M. de Vos
Willem M. de Vos Wageningen University & Research
Sarah Lebeer
Sarah Lebeer University of Antwerp
Peter A. Bron
Peter A. Bron University of Antwerp
Robert P. Hausinger
Robert P. Hausinger Michigan State University

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