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Biology and Biochemistry

D-Index
87
Citations
54918
World Ranking
2766
National Ranking
1427

Research.com Recognitions

  • 2019 - Fellow, National Academy of Inventors
  • 2019 - Member of the National Academy of Engineering For discovery of CRISPR-Cas genome editing and engineering microbes, plants, and animals for food and other applications.
  • 2018 - Member of the National Academy of Sciences
  • 2016 - Canada Gairdner International Award
  • 2016 - Warren Alpert Foundation Prize For remarkable contributions to the understanding of the CRISPR bacterial defense system and the revolutionary discovery that it can be adapted for genome editing.

Overview

Rodolphe Barrangou is affiliated with North Carolina State University in the United States. Their research focus is primarily within the field of Biochemistry, Genetics, and Molecular Biology, with a notable emphasis on Molecular Biology. Additional subfields include Food Science, Ecology, Infectious Diseases, and Business and International Management.

Their scholarly work frequently covers topics such as CRISPR and Genetic Engineering, Bacteriophages and microbial interactions, Probiotics and Fermented Foods, Gut microbiota and health, RNA and protein synthesis mechanisms, Innovation and Socioeconomic Development, and Clostridium difficile and Clostridium perfringens research.

Rodolphe Barrangou has a publication record that includes multiple appearances in renowned venues. The frequent publication venues consist of The CRISPR Journal, Proceedings of the National Academy of Sciences, Nature Microbiology, Frontiers in Microbiology, and bioRxiv (Cold Spring Harbor Laboratory).

Recent papers authored or co-authored by Barrangou include the following:

  • Species- and site-specific genome editing in complex bacterial communities, 2021, Nature Microbiology
  • In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials, 2020, mBio
  • Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization, 2021, Proceedings of the National Academy of Sciences
  • Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut, 2023, Nature Microbiology
  • Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing, 2022, Nature Microbiology

Frequent co-authors collaborating with Barrangou include:

  • Sarah O'Flaherty
  • Meichen Pan
  • Matthew A. Nethery
  • Casey M. Theriot
  • Jennifer A. Doudna

Rodolphe Barrangou has received a number of awards recognizing contributions to their field. These honors include membership in the National Academy of Engineering (2019) for discoveries related to CRISPR-Cas genome editing and engineering microbes, plants, and animals for food and other applications, fellowship in the National Academy of Inventors (2019), and membership in the National Academy of Sciences (2018). Prior recognitions include the Canada Gairdner International Award (2016) and the Warren Alpert Foundation Prize (2016) for contributions to understanding the CRISPR bacterial defense system and its application to genome editing.

Best Publications

  • CRISPR provides acquired resistance against viruses in prokaryotes

    Rodolphe Barrangou;Christophe Fremaux;Hélène Deveau;Melissa Richards

  • Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

    Giedrius Gasiunas;Rodolphe Barrangou;Philippe Horvath;Virginijus Siksnys

  • Evolution and classification of the CRISPR-Cas systems

    Kira S. Makarova;Daniel H. Haft;Rodolphe Barrangou;Stan J. J. Brouns

  • The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA.

    Josiane E. Garneau;Marie Ève Dupuis;Manuela Villion;Dennis A. Romero

  • CRISPR/Cas, the Immune System of Bacteria and Archaea

    Philippe Horvath;Rodolphe Barrangou

  • An updated evolutionary classification of CRISPR–Cas systems

    Kira S. Makarova;Yuri I. Wolf;Omer S. Alkhnbashi;Fabrizio Costa

  • Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.

    Kira S. Makarova;Yuri I. Wolf;Jaime Iranzo;Sergey A. Shmakov

  • Comparative genomics of the lactic acid bacteria

    K. Makarova;A. Slesarev;Y. Wolf;A. Sorokin

  • Phage response to CRISPR-encoded resistance in Streptococcus thermophilus.

    Hélène Deveau;Rodolphe Barrangou;Josiane E. Garneau;Jessica Labonté

  • CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation

    Devaki Bhaya;Michelle Davison;Michelle Davison;Rodolphe Barrangou

  • The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

    Rimantas Sapranauskas;Giedrius Gasiunas;Christophe Fremaux;Rodolphe Barrangou

  • Diversity, Activity, and Evolution of CRISPR Loci in Streptococcus thermophilus

    Philippe Horvath;Dennis A. Romero;Anne Claire Coûté-Monvoisin;Melissa Richards

  • Applications of CRISPR technologies in research and beyond

    Rodolphe Barrangou;Jennifer A Doudna

  • CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity

    Rodolphe Barrangou;Luciano A. Marraffini

  • Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM

    Eric Altermann;W. Michael Russell;M. Andrea Azcarate-Peril;Rodolphe Barrangou

  • The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533

    R. David Pridmore;Bernard Berger;Frank Desiere;David Vilanova

  • Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera

    Zhihong Sun;Hugh M B Harris;Angela McCann;Chenyi Guo

  • Cas3 is a single‐stranded DNA nuclease and ATP‐dependent helicase in the CRISPR/Cas immune system

    Tomas Sinkunas;Giedrius Gasiunas;Christophe Fremaux;Rodolphe Barrangou

  • Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems.

    Ahmed A. Gomaa;Heidi E. Klumpe;Michelle L. Luo;Kurt Selle

  • Comparative analysis of CRISPR loci in lactic acid bacteria genomes.

    Philippe Horvath;Anne Claire Coûté-Monvoisin;Dennis A. Romero;Patrick Boyaval

Frequent Co-Authors

Todd R. Klaenhammer
Todd R. Klaenhammer North Carolina State University
Eric Altermann
Eric Altermann Massey University
Sylvain Moineau
Sylvain Moineau Université Laval
Birte Svensson
Birte Svensson Technical University of Denmark
Chase L. Beisel
Chase L. Beisel University of Würzburg
Virginijus Siksnys
Virginijus Siksnys Vilnius University
John van der Oost
John van der Oost Wageningen University & Research
Jillian F. Banfield
Jillian F. Banfield University of California, Berkeley
Kira S. Makarova
Kira S. Makarova National Institutes of Health
Yuri I. Wolf
Yuri I. Wolf National Institutes of Health

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