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Genetics

D-Index
57
Citations
25796
World Ranking
3356
National Ranking
119

Overview

Stan J. J. Brouns is affiliated with Delft University of Technology in the Netherlands. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Environmental Science. Within these fields, Brouns has contributed notably to subfields including Molecular Biology, Ecology, Microbiology, Genetics, and Epidemiology.

The main topics explored in Brouns' work comprise:

  • Bacteriophages and microbial interactions
  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • Genomics and Phylogenetic Studies
  • Microbial infections and disease research
  • Insect symbiosis and bacterial influences
  • Advanced biosensing and bioanalysis techniques

Frequent publication venues where Brouns' research has appeared include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cell Host & Microbe
  • The CRISPR Journal
  • Science

Among notable recent papers authored or coauthored by Brouns are:

  • "Mechanisms and clinical importance of bacteriophage resistance" (2021), published in FEMS Microbiology Reviews
  • "Short prokaryotic Argonaute systems trigger cell death upon detection of invading DNA" (2022), published in Cell
  • "The gRAMP CRISPR-Cas effector is an RNA endonuclease complexed with a caspase-like peptidase" (2021), published in Science
  • "Approaches for bacteriophage genome engineering" (2022), published in Trends in biotechnology
  • "RNA-targeting CRISPR-Cas systems" (2022), published in Nature Reviews Microbiology

Frequent collaborators in Brouns' research include:

  • Ana Rita Costa
  • Daan F. van den Berg
  • Franklin L. Nóbrega
  • Anna C. Haagsma
  • Pieter-Jan Haas

Best Publications

  • Small CRISPR RNAs guide antiviral defense in prokaryotes

    Stan J. J. Brouns;Matthijs M. Jore;Magnus Lundgren;Edze R. Westra

  • Evolution and classification of the CRISPR-Cas systems

    Kira S. Makarova;Daniel H. Haft;Rodolphe Barrangou;Stan J. J. Brouns

  • An updated evolutionary classification of CRISPR–Cas systems

    Kira S. Makarova;Yuri I. Wolf;Omer S. Alkhnbashi;Fabrizio Costa

  • Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.

    Kira S. Makarova;Yuri I. Wolf;Jaime Iranzo;Sergey A. Shmakov

  • Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

    Ekaterina Semenova;Matthijs M. Jore;Kirill A. Datsenko;Anna Semenova

  • Structural basis for CRISPR RNA-guided DNA recognition by Cascade

    Matthijs M Jore;Magnus Lundgren;Magnus Lundgren;Esther van Duijn;Jelle B Bultema

  • CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3

    Edze R. Westra;Paul B.G. van Erp;Tim Künne;Shi Pey Wong

  • CRISPR-based adaptive and heritable immunity in prokaryotes.

    John van der Oost;Matthijs M. Jore;Edze R. Westra;Magnus Lundgren

  • Targeting mechanisms of tailed bacteriophages

    Franklin L Nobrega;Marnix Vlot;Patrick A de Jonge;Patrick A de Jonge;Lisa L Dreesens

  • Dna-guided dna interference by a prokaryotic argonaute

    Der Oost John Van;Daniël Christianus Swarts;Andrew Paul May;Rachel E. Haurwitz

  • Structures of the RNA-guided surveillance complex from a bacterial immune system

    Blake Wiedenheft;Gabriel C. Lander;Kaihong Zhou;Matthijs M. Jore

  • CRISPR Interference Directs Strand Specific Spacer Acquisition

    Daan C. Swarts;Cas Mosterd;Mark W. J. van Passel;Stan J. J. Brouns

  • CRISPR-Cas: Adapting to change.

    Simon A. Jackson;Rebecca E. McKenzie;Robert D. Fagerlund;Sebastian N. Kieper

  • The CRISPRs, They Are A-Changin': How Prokaryotes Generate Adaptive Immunity

    Edze R Westra;Daan C Swarts;Raymond H J Staals;Matthijs M Jore

  • Molecular and Evolutionary Determinants of Bacteriophage Host Range

    Patrick A. de Jonge;Patrick A. de Jonge;Franklin L. Nobrega;Stan J.J. Brouns;Stan J.J. Brouns;Bas E. Dutilh;Bas E. Dutilh

  • CRISPRTarget: bioinformatic prediction and analysis of crRNA targets.

    Ambarish Biswas;Joshua N. Gagnon;Stan J.J. Brouns;Peter C. Fineran

  • Crystal structure of the CRISPR RNA–guided surveillance complex from Escherichia coli

    Ryan N. Jackson;Sarah M. Golden;Paul B. G. van Erp;Joshua Carter

  • Degenerate target sites mediate rapid primed CRISPR adaptation

    Peter C. Fineran;Matthias J. H. Gerritzen;María Suárez-Diez;Tim Künne

  • H-NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO

    Edze R. Westra;Ümit Pul;Nadja Heidrich;Matthijs M. Jore

  • Improving the performance of a Quadrupole Time-of-Flight instrument for Macromolecular Mass Spectrometry

    Robert H H van den Heuvel;Esther van Duijn;Hortense Mazon;Silvia A Synowsky

Frequent Co-Authors

John van der Oost
John van der Oost Wageningen University & Research
Edze R. Westra
Edze R. Westra University of Exeter
Bas E. Dutilh
Bas E. Dutilh Utrecht University
Ambrosius P. Snijders
Ambrosius P. Snijders The Francis Crick Institute
Willem M. de Vos
Willem M. de Vos Wageningen University & Research
Konstantin Severinov
Konstantin Severinov Rutgers, The State University of New Jersey
Blake Wiedenheft
Blake Wiedenheft Montana State University
Peter C. Fineran
Peter C. Fineran University of Otago
Eugene V. Koonin
Eugene V. Koonin National Institutes of Health
Kira S. Makarova
Kira S. Makarova National Institutes of Health

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