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Biology and Biochemistry

D-Index
47
Citations
22130
World Ranking
18530
National Ranking
7564

Overview

Blake Wiedenheft is affiliated with Montana State University in the United States. Their research primarily spans the field of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology, Infectious Diseases, Ecology, Genetics, and Plant Science as subfields of study.

The scientist's work covers several main topics, including:

  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • Bacteriophages and microbial interactions
  • RNA modifications and cancer
  • SARS-CoV-2 and COVID-19 Research
  • Advanced biosensing and bioanalysis techniques
  • SARS-CoV-2 detection and testing

Blake Wiedenheft has contributed to multiple recent papers, illustrating ongoing involvement in COVID-19 related research and CRISPR immune systems. Selected papers include:

  • "Temporal Detection and Phylogenetic Assessment of SARS-CoV-2 in Municipal Wastewater," 2020, Cell Reports Medicine
  • "Temporal detection and phylogenetic assessment of SARS-CoV-2 in municipal wastewater," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Structures and Strategies of Anti-CRISPR-Mediated Immune Suppression," 2020, Annual Review of Microbiology
  • "SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression," 2021, Cell Reports
  • "Intrinsic signal amplification by type III CRISPR-Cas systems provides a sequence-specific SARS-CoV-2 diagnostic," 2021, Cell Reports Medicine

The research has been published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), EMPIAR dataset, The CRISPR Journal, and SSRN Electronic Journal.

Frequent collaborators include:

  • Artem Nemudryi
  • Tanner Wiegand
  • Anna Nemudraia
  • Royce A. Wilkinson
  • Andrew Santiago-Frangos

Best Publications

  • Unravelling the structural and mechanistic basis of CRISPR-Cas systems.

    John van der Oost;Edze R. Westra;Edze R. Westra;Ryan N. Jackson;Blake Wiedenheft

  • RNA-guided genetic silencing systems in bacteria and archaea

    Blake Wiedenheft;Samuel H. Sternberg;Jennifer A. Doudna

  • Sequence- and structure-specific RNA processing by a CRISPR endonuclease.

    Rachel E. Haurwitz;Martin Jinek;Blake Wiedenheft;Kaihong Zhou

  • CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea

    Rotem Sorek;C. Martin Lawrence;Blake Wiedenheft

  • Structural basis for CRISPR RNA-guided DNA recognition by Cascade

    Matthijs M Jore;Magnus Lundgren;Magnus Lundgren;Esther van Duijn;Jelle B Bultema

  • RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

    Blake Wiedenheft;Esther van Duijn;Jelle B. Bultema;Sakharam P. Waghmare

  • Structures of the RNA-guided surveillance complex from a bacterial immune system

    Blake Wiedenheft;Gabriel C. Lander;Kaihong Zhou;Matthijs M. Jore

  • Temporal Detection and Phylogenetic Assessment of SARS-CoV-2 in Municipal Wastewater.

    Artem Nemudryi;Anna Nemudraia;Tanner Wiegand;Kevin Surya

  • Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins

    Joseph Bondy-Denomy;Bianca Garcia;Scott Strum;Mingjian Du

  • Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System

    Dipali G. Sashital;Blake Wiedenheft;Jennifer A. Doudna

  • Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense.

    Blake Wiedenheft;Kaihong Zhou;Martin Jinek;Scott M. Coyle

  • Crystal structure of the CRISPR RNA–guided surveillance complex from Escherichia coli

    Ryan N. Jackson;Sarah M. Golden;Paul B. G. van Erp;Joshua Carter

  • Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition.

    Edze R. Westra;Ekaterina Semenova;Kirill A. Datsenko;Ryan N. Jackson

  • Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex

    Saikat Chowdhury;Joshua Carter;MaryClare F. Rollins;Sarah M. Golden

  • Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System

    Sy Redding;Samuel H. Sternberg;Myles Marshall;Bryan Gibb

  • Viruses from extreme thermal environments.

    George Rice;Kenneth Stedman;Jamie Snyder;Blake Wiedenheft

  • Endoribonuclease compositions and methods of use thereof

    Rachel E. Haurwitz;Jennifer A. Doudna;Blake Wiedenheft;Martin Jinek

  • Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.

    Robert P. Hayes;Yibei Xiao;Fran Ding;Paul B. G. van Erp

  • Methods of generating nucleic acid fragments

    Blake Wiedenheft;Kaihong Zhou;Jennifer A. Doudna

  • Temporal Detection and Phylogenetic Assessment of SARS-CoV-2 in Municipal Wastewater

    Artem Nemudryi;Anna Nemudraia;Tanner Wiegand;Kevin Surya

Frequent Co-Authors

Jennifer A. Doudna
Jennifer A. Doudna University of California, Berkeley
Mark J. Young
Mark J. Young Montana State University
Trevor Douglas
Trevor Douglas Indiana University
Martin Jinek
Martin Jinek University of Zurich
Joseph Bondy-Denomy
Joseph Bondy-Denomy University of California, San Francisco
Mark A. Jutila
Mark A. Jutila Montana State University
Edze R. Westra
Edze R. Westra University of Exeter
Stan J. J. Brouns
Stan J. J. Brouns Delft University of Technology
Alan R. Davidson
Alan R. Davidson University of Toronto
John van der Oost
John van der Oost Wageningen University & Research

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