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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
101
Citations
59641
World Ranking
1408
National Ranking
22

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

John van der Oost is affiliated with Wageningen University & Research in the Netherlands. Their research primarily falls within the field of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Molecular Biology among their 145 publications. Subfields of their work also include Genetics, Biomedical Engineering, Business and International Management, and Cardiology and Cardiovascular Medicine.

The main topics covered by John van der Oost's research include:

  • CRISPR and Genetic Engineering
  • Microbial Metabolic Engineering and Bioproduction
  • RNA and protein synthesis mechanisms
  • Advanced biosensing and bioanalysis techniques
  • Bacterial Genetics and Biotechnology
  • Innovation and Socioeconomic Development
  • Biofuel production and bioconversion

They have published extensively on CRISPR-related technologies and diagnostics, which is reflected in some of their recent papers:

  • "Enhancement of CRISPR/Cas12a trans-cleavage activity using hairpin DNA reporters" (2022), published in Nucleic Acids Research
  • "Good guide, bad guide: spacer sequence-dependent cleavage efficiency of Cas12a" (2020), published in Nucleic Acids Research
  • "Towards a synthetic cell cycle" (2021), published in Nature Communications
  • "SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation" (2021), published in Nature Communications
  • "Cryo-EM structure of the transposon-associated TnpB enzyme" (2023), published in Nature

Frequent publication venues for John van der Oost include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Trends in Biotechnology
  • Nucleic Acids Research
  • The CRISPR Journal
  • Research Square (Research Square)

The scientist has collaborated multiple times with several co-authors, notable among them are:

  • Raymond H.J. Staals (22 publications)
  • Servé W. M. Kengen (15 publications)
  • Constantinos Patinios (12 publications)
  • Nico J. Claassens (11 publications)
  • Ruud A. Weusthuis (9 publications)

Best Publications

  • Unravelling the structural and mechanistic basis of CRISPR-Cas systems.

    John van der Oost;Edze R. Westra;Edze R. Westra;Ryan N. Jackson;Blake Wiedenheft

  • Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.

    Bernd Zetsche;Jonathan S. Gootenberg;Omar O. Abudayyeh;Ian M. Slaymaker

  • Small CRISPR RNAs guide antiviral defense in prokaryotes

    Stan J. J. Brouns;Matthijs M. Jore;Magnus Lundgren;Edze R. Westra

  • Evolution and classification of the CRISPR-Cas systems

    Kira S. Makarova;Daniel H. Haft;Rodolphe Barrangou;Stan J. J. Brouns

  • An updated evolutionary classification of CRISPR–Cas systems

    Kira S. Makarova;Yuri I. Wolf;Omer S. Alkhnbashi;Fabrizio Costa

  • Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.

    Kira S. Makarova;Yuri I. Wolf;Jaime Iranzo;Sergey A. Shmakov

  • Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

    Ekaterina Semenova;Matthijs M. Jore;Kirill A. Datsenko;Anna Semenova

  • The complete genome of the crenarchaeon Sulfolobus solfataricus P2.

    Qunxin She;Rama K. Singh;Fabrice Confalonieri;Yvan Zivanovic

  • Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array

    Bernd Zetsche;Matthias Heidenreich;Prarthana Mohanraju;Iana Fedorova

  • Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome

    Víctor J. Carrión;Juan Perez-Jaramillo;Viviane Cordovez;Vittorio Tracanna

  • Codon Bias as a Means to Fine-Tune Gene Expression

    Tessa E.F. Quax;Tessa E.F. Quax;Nico J. Claassens;Dieter Söll;John van der Oost

  • Structural basis for CRISPR RNA-guided DNA recognition by Cascade

    Matthijs M Jore;Magnus Lundgren;Magnus Lundgren;Esther van Duijn;Jelle B Bultema

  • CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3

    Edze R. Westra;Paul B.G. van Erp;Tim Künne;Shi Pey Wong

  • CRISPR-based adaptive and heritable immunity in prokaryotes.

    John van der Oost;Matthijs M. Jore;Edze R. Westra;Magnus Lundgren

  • Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems.

    Prarthana Mohanraju;Kira S. Makarova;Bernd Zetsche;Feng Zhang

  • Dna-guided dna interference by a prokaryotic argonaute

    Der Oost John Van;Daniël Christianus Swarts;Andrew Paul May;Rachel E. Haurwitz

  • Structures of the RNA-guided surveillance complex from a bacterial immune system

    Blake Wiedenheft;Gabriel C. Lander;Kaihong Zhou;Matthijs M. Jore

  • Healthy human gut phageome

    Pilar Manrique;Benjamin Bolduc;Seth T. Walk;John van der Oost

  • The evolutionary journey of Argonaute proteins

    Daan C Swarts;Kira Makarova;Yanli Wang;Kotaro Nakanishi

  • Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.

    Daan C. Swarts;John van der Oost;Martin Jinek

Frequent Co-Authors

Willem M. de Vos
Willem M. de Vos Wageningen University & Research
Stan J. J. Brouns
Stan J. J. Brouns Delft University of Technology
Servé W. M. Kengen
Servé W. M. Kengen Wageningen University & Research
Edze R. Westra
Edze R. Westra University of Exeter
Hauke Smidt
Hauke Smidt Wageningen University & Research
Kira S. Makarova
Kira S. Makarova National Institutes of Health
Eugene V. Koonin
Eugene V. Koonin National Institutes of Health
Thijs J. G. Ettema
Thijs J. G. Ettema Wageningen University & Research
Jennifer A. Doudna
Jennifer A. Doudna University of California, Berkeley
Ambrosius P. Snijders
Ambrosius P. Snijders The Francis Crick Institute

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