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Genetics
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2026

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Best Scientists

D-Index
248
Citations
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World Ranking
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National Ranking
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Genetics

D-Index
250
Citations
276475
World Ranking
4
National Ranking
3

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Genetics in United States Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2016 - Member of the National Academy of Sciences
  • 2013 - Fellow of the American Academy of Arts and Sciences

Overview

Eugene V. Koonin is affiliated with the National Institutes of Health in the United States. Their research spans multiple scientific fields, primarily focusing on environmental science as well as biochemistry, genetics, and molecular biology.

Their work is distinguished by contributions to several subfields, including molecular biology, statistical and nonlinear physics, environmental engineering, sociology and political science, and ecology.

Key topics explored in their research include:

  • Advanced thermodynamics and statistical mechanics
  • Sustainability and ecological systems analysis
  • Evolutionary game theory and cooperation
  • Bacteriophages and microbial interactions
  • Plant virus research studies
  • Microbial infections and disease research
  • CRISPR and genetic engineering

Recent publications by Eugene V. Koonin demonstrate the scope and interdisciplinary nature of their research. Notable papers include:

  • "Thermodynamic selection: mechanisms and scenarios," 2022, published in New Journal of Physics
  • "DNA polymerase swapping in Caudoviricetes bacteriophages," 2024, published in Virology Journal
  • "Biochemical plasticity of the Escherichia coli CRISPR Cascade revealed by in vitro reconstitution of Cascade activities from purified Cas proteins," 2024, published in FEBS Journal

Collaborations form an integral part of their work. Frequent co-authors include:

  • S. G. Babajanyan
  • A. E. Allahverdyan
  • Natalya Yutin
  • Igor Tolstoy
  • Pascal Mutz

Publication venues reflect the interdisciplinary and international interest in their research, with frequent contributions to journals such as:

  • New Journal of Physics
  • Virology Journal
  • FEBS Journal

Awards recognizing their contributions include membership in the National Academy of Sciences since 2016 and fellowship of the American Academy of Arts and Sciences since 2013.

Best Publications

  • Initial sequencing and analysis of the human genome.

    Eric S. Lander;Lauren M. Linton;Bruce Birren;Chad Nusbaum

  • The COG database: an updated version includes eukaryotes

    Roman L Tatusov;Natalie D Fedorova;John D Jackson;Aviva R Jacobs

  • Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.

    Bernd Zetsche;Jonathan S. Gootenberg;Omar O. Abudayyeh;Ian M. Slaymaker

  • The COG database: a tool for genome-scale analysis of protein functions and evolution

    Roman L. Tatusov;Michael Y. Galperin;Darren A. Natale;Eugene V. Koonin

  • A GENOMIC PERSPECTIVE ON PROTEIN FAMILIES

    Roman L. Tatusov;Eugene V. Koonin;David J. Lipman

  • Small CRISPR RNAs guide antiviral defense in prokaryotes

    Stan J. J. Brouns;Matthijs M. Jore;Magnus Lundgren;Edze R. Westra

  • Evolution and classification of the CRISPR-Cas systems

    Kira S. Makarova;Daniel H. Haft;Rodolphe Barrangou;Stan J. J. Brouns

  • Nucleic acid detection with CRISPR-Cas13a/C2c2

    Jonathan S. Gootenberg;Omar O. Abudayyeh;Jeong Wook Lee;Patrick Essletzbichler

  • An updated evolutionary classification of CRISPR–Cas systems

    Kira S. Makarova;Yuri I. Wolf;Omer S. Alkhnbashi;Fabrizio Costa

  • In vivo genome editing using Staphylococcus aureus Cas9

    F. Ann Ran;Le Cong;Winston X. Yan;David A. Scott

  • Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.

    Kira S. Makarova;Yuri I. Wolf;Jaime Iranzo;Sergey A. Shmakov

  • Crystal structure of Cas9 in complex with guide RNA and target DNA

    Takashi Yamano;Hiroshi Nishimasu;Hiroshi Nishimasu;Bernd Zetsche;Hisato Hirano

  • AAA+: A Class of Chaperone-Like ATPases Associated with the Assembly, Operation, and Disassembly of Protein Complexes

    Andrew F. Neuwald;L. Aravind;John L. Spouge;Eugene V. Koonin

  • The COG database: new developments in phylogenetic classification of proteins from complete genomes

    Roman L. Tatusov;Darren A. Natale;Igor V. Garkavtsev;Tatiana A. Tatusova

  • De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

    Ingrid E. Wertz;Karen M. O'Rourke;Honglin Zhou;Michael Eby

  • C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

    Omar O. Abudayyeh;Jonathan S. Gootenberg;Silvana Konermann;Silvana Konermann;Silvana Konermann;Julia Joung;Julia Joung;Julia Joung

  • Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent

    Jeff Linnen;John Wages;Zhen-Yong Zhang-Keck;Kirk E. Fry

  • Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis

    Richard S. Stephens;Sue Kalman;Claudia Lammel;Jun Fan

  • Bacterial Rhodopsin: Evidence for a New Type of Phototrophy in the Sea

    Oded Béjà;L. Aravind;Eugene V. Koonin;Marcelino T. Suzuki

  • Comparative genomics of the lactic acid bacteria

    K. Makarova;A. Slesarev;Y. Wolf;A. Sorokin

Frequent Co-Authors

Yuri I. Wolf
Yuri I. Wolf National Institutes of Health
Kira S. Makarova
Kira S. Makarova National Institutes of Health
L. Aravind
L. Aravind National Institutes of Health
Igor B. Rogozin
Igor B. Rogozin National Institutes of Health
Michael Y. Galperin
Michael Y. Galperin National Institutes of Health
Mart Krupovic
Mart Krupovic Université Paris Cité
Natalya Yutin
Natalya Yutin National Institutes of Health
Valerian V. Dolja
Valerian V. Dolja Oregon State University
Alexander E. Gorbalenya
Alexander E. Gorbalenya Leiden University

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