Robert Rottapel

Overview

Best Publications

• Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA

  Akihide Ryo;Futoshi Suizu;Yasuhiro Yoshida;Kilian Perrem

  819
  Citations

• Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

  Françoise Pagès;Marguerite Ragueneau;Robert Rottapel;Robert Rottapel;Alemseged Truneh

  496
  Citations

• The MAGUK family protein CARD11 is essential for lymphocyte activation.

  Hiromitsu Hara;Teiji Wada;Teiji Wada;Chris Bakal;Ivona Kozieradzki;Ivona Kozieradzki

  403
  Citations

• Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

  Traver Hart;Kevin R Brown;Fabrice Sircoulomb;Robert Rottapel;Robert Rottapel;Robert Rottapel

  381
  Citations

• W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor

  A D Reith;R Rottapel;E Giddens;C Brady

  374
  Citations

• Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells

  Richard Marcotte;Kevin R. Brown;Fernando Suarez;Azin Sayad

  369
  Citations

• The c-kit receptor ligand functions as a mast cell chemoattractant.

  Cynthia J. Meininger;Hiroshi Yano;Robert Rottapel;Alan Bernstein

  365
  Citations

• The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

  R Rottapel;M Reedijk;D E Williams;S D Lyman

  302
  Citations

• A point mutation in CD28 distinguishes proliferative signals from survival signals.

  Klaus Okkenhaug;Klaus Okkenhaug;Linda Wu;Kristine M. Garza;Jose La Rose

  268
  Citations

• SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.

  Maya Kozlowski;Louise Larose;Fai Lee;Duc Mingh Le

  264
  Citations

• Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

  Sebastian Guettler;Sebastian Guettler;Jose LaRose;Evangelia Petsalaki;Evangelia Petsalaki;Gerald Gish

  254
  Citations

• Socs1 binds to multiple signalling proteins and suppresses Steel factor-dependent proliferation

  Paulo De Sepulveda;Klaus Okkenhaug;Klaus Okkenhaug;Jose La Rose;Robert G. Hawley

  238
  Citations

• Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

  Paulo De Sepulveda;Subburaj Ilangumaran;Robert Rottapel;Robert Rottapel

  222
  Citations

• The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor.

  Galland F;Karamysheva A;Pebusque Mj;Borg Jp

  208
  Citations

• Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins

  Ioannis D. Dimitriou;Liliana Clemenza;Liliana Clemenza;Andrew J. Scotter;Grace Chen;Grace Chen

  207
  Citations

• Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region

  Perry M. Chan;Subburaj Ilangumaran;Jose La Rose;Avijit Chakrabartty

  197
  Citations

• Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism

  Noam Levaot;Oleksandr Voytyuk;Ioannis Dimitriou;Fabrice Sircoulomb

  194
  Citations

• CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

  Russell G. Jones;Alisha R. Elford;Michael J. Parsons;Linda Wu

  190
  Citations

• The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.

  Paul A. Spagnuolo;Jiayi Hu;Rose Hurren;Xiaoming Wang

  178
  Citations

• Constitutive p38HOG Mitogen-activated Protein Kinase Activation Induces Permanent Cell Cycle Arrest and Senescence

  Rizwan Haq;James D Brenton;Mark Takahashi;Dina Finan

  174
  Citations